Protein Alignment metro and Mpp2

DIOPT Version :10

• Sequence 1: NP_610642.2
• Gene: metro / 36176
• FlyBaseID: FBgn0050021
• Length: 595
• Species: Drosophila melanogaster
• Sequence 2: XP_008766350.1
• Gene: Mpp2 / 85275
• RGDID: 620014
• Length: 569
• Species: Rattus norvegicus
• Alignment Length: 592
• Identity: 207/592 - (34%)
• Similarity: 325/592 - (54%)
• Gaps: 63/592 - (10%)

  Fly    15 ALSKLISTLKESENLSNDQEID--FLKALLESKELNALVNVHTKVAKVGRDDRLAPVLSTSAQVL 77
            |:.:::..|....|.:...|:|  ||:.::||..:.:|...|.::    .:.:|..|...:.:::
  Rat    28 AMQQVLDNLGSLPNATGAAELDLIFLRGIMESPIVRSLAKAHERL----EETKLEAVRDNNLELV 88

  Fly    78 YEVLEQLSQHCHLNDDCKEAFHLLQDSHLQHLLFAHDAIAQKDFYPHLPEAPVEMDEDEETIKIV 142
            .|:|..|::....:....|...:||:.|.|.||..||::|.|.:     |.|......:.|.
  Rat    89 QEILRDLAELAEQSSTAAELARILQEPHFQSLLETHDSVASKTY-----ETPPPSPGLDPTF--- 145

  Fly   143 QLVKSNEP-------LTGAQSTE-PIVGATIKTDEESGKIIIARIMHGGAADRSGLIHVGDEVIE 199
                ||:|       :.|.:.|. ..:|.|.:.  |.|:::||||:|||...:.||:||||.:.|
  Rat   146 ----SNQPVPPDAVRMVGIRKTAGEHLGVTFRV--EGGELVIARILHGGMVAQQGLLHVGDIIKE 204

  Fly   200 VNNINVEGKTPGDVLTILQNSEGTITFKLVPADNKGAQRESKVRVRAHFDYNPDVDPYIPCKEAG 264
            ||...| |..|..:..:|:::.|::..|::|:..: .....:|.|:.||||:|..|..|||||||
  Rat   205 VNGQPV-GSDPRALQELLRSASGSVILKILPSYQE-PHLPRQVFVKCHFDYDPARDSLIPCKEAG 267

  Fly   265 LAFQRGDVLHIVAQDDAYWWQARKEHERSARAGLIPSRALQERRILHDRTQKNGTDLDSKPGSCA 329
            |.|..||:|.||.||||.||||.  |.....||||||:.|:|:|....:     .||:..|.| .
  Rat   268 LRFNAGDLLQIVNQDDANWWQAC--HVEGGSAGLIPSQLLEEKRKAFVK-----RDLELTPTS-G 324

  Fly   330 SLCTTPPGSPRLPASSSTSSCRQPKTKKIMYDLTENDDFDREQIATYEEVAKLYPRPGVFR--PI 392
            :||.:..|.               |.|::||..|:|.:|||.::..|||||::.|    ||  .:
  Rat   325 TLCGSLSGK---------------KKKRMMYLTTKNAEFDRHELLIYEEVARMPP----FRRKTL 370

  Fly   393 VLIGAPGVGRNELRRRLIARDPEKFRSPVPYTTRPMRTGEVAGREYIFVAREKMDADIEAGKFVE 457
            |||||.||||..|:.:||..||:::.:.||||:|..:..|..|:.|.||:|.:|:|||.||:::|
  Rat   371 VLIGAQGVGRRSLKNKLILWDPDRYGTTVPYTSRRPKDSEREGQGYSFVSRGEMEADIRAGRYLE 435

  Fly   458 HGEYKGHLYGTSAESVKSIVNAGCVCVLSPHYQAIKTLRTAQLKPFLIHVKPPELDILKATRTEA 522
            ||||:|:||||..:|::.:|.:|.||||..:.||:|.||||:..|:::.::.|:.:.|:|....|
  Rat   436 HGEYEGNLYGTRIDSIRGVVASGKVCVLDVNPQAVKVLRTAEFVPYVVFIEAPDFETLRAMNRAA 500

  Fly   523 RAKSTFDEANARSFTDEEFEDMIKSAERIDFLYGHFFDVELVNGELVNAFEQLVQNVQRLENEPV 587
            ....    .:.:..|:.:....::.:.||...|||:||:.|||..|...|.:|...:::|..||.
  Rat   501 LESG----VSTKQLTEADLRRTVEESSRIQRGYGHYFDLSLVNSNLERTFRELQTAMEKLRTEPQ 561

  Fly   588 WAPSMWV 594
            |.|..||
  Rat   562 WVPVSWV 568

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
metro	NP_610642.2	L27	17..68	CDD:197794	11/52 (21%)
		L27	75..127	CDD:197794	14/51 (27%)
		PDZ_MPP3-MPP4-MPP7-like	140..230	CDD:467260	31/97 (32%)
		SH3_MPP	243..302	CDD:212796	35/58 (60%)
		Guanylate_kin	390..575	CDD:395500	74/186 (40%)
Mpp2	XP_008766350.1	L27	30..83	CDD:197794	12/56 (21%)
		L27	85..136	CDD:460717	15/55 (27%)
		PDZ_MPP6-MPP2-like	156..234	CDD:467268	28/80 (35%)
		SH3_MPP2	246..304	CDD:212970	36/59 (61%)
		GuKc	376..557	CDD:214504	69/184 (38%)