DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment metro and mpp3b

DIOPT Version :9

Sequence 1:	NP_610642.2	Gene:	metro / 36176	FlyBaseID:	FBgn0050021	Length:	595	Species:	Drosophila melanogaster
Sequence 2:	XP_001340190.2	Gene:	mpp3b / 799884	ZFINID:	ZDB-GENE-121214-128	Length:	587	Species:	Danio rerio

Alignment Length:	611	Identity:	229/611 - (37%)
Similarity:	350/611 - (57%)	Gaps:	69/611 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LSKLISTLKESENLSNDQEIDFLKALLESKELNALVNVHTKVAKVGRDDRL---APVLSTSAQVL 77
            |:.|.|.|....|  :.:::.||:.:...:.|:.|:.:|.::    |...|   .|||.:::.:.
Zfish    14 LALLTSQLHPEAN--HKEDLVFLREVFSERSLSYLMKIHERL----RQFHLYSPTPVLHSASCLA 72

  Fly    78 YEVLEQLSQHCHLNDDCKEAFHLLQDSHLQHLLFAHDAIAQKDFYPHLPEAPVEMDE--DEETIK 140
            .:|.|:| |:..|.:|.:|...||...|::.:|..||.:|||:|.|.||..|.::::  :||::|
Zfish    73 EDVAEEL-QNGSLEEDERELLALLSTPHIKAVLTVHDTVAQKNFEPVLPPLPNDLEDELEEESVK 136

  Fly   141 IVQLVKSNEPLTGAQSTEPIVGATIKTDEESGKIIIARIMHGGAADRSGLIHVGDEVIEVNNINV 205
            ||:|||:.|||          ||||:.||.:|.:::||||.|||||||||:|||||:.|||...:
Zfish   137 IVRLVKNKEPL----------GATIRRDEVTGAVVVARIMRGGAADRSGLVHVGDELREVNGNLI 191

  Fly   206 EGKTPGDVLTILQNSEGTITFKLVPA-DNKGAQRESKVRVRAHFDYNPDVDPYIPCKEAGLAFQR 269
            ..|.|.::..||..|:|:||.|::|| ..:...:||||.:||.|||.|..|...||:||||.|..
Zfish   192 IHKRPEEISQILSQSQGSITLKIIPAIKEEDRFKESKVYLRALFDYTPYEDRATPCQEAGLPFLC 256

  Fly   270 GDVLHIVAQDDAYWWQARKEHERSARAGLIPSRALQERRILHDRTQKNGT--------------- 319
            ||||.:|:|||..||||::..:.:.||||||||..||||:|:  ..|.||
Zfish   257 GDVLQVVSQDDPTWWQAKRVGDSNLRAGLIPSRQFQERRLLY--RMKMGTHQSPKSPRATPCDQT 319

  Fly   320 ----DLDSKPGSCASLCTTPPGSPRLPASSSTSSCRQPKTKKIMYDLTENDDFDREQIATYEEVA 380
                |.||:.............|.||.......|.::..|.    :.|||      :...||||.
Zfish   320 CEKEDCDSESSVSGQHVAGLRRSFRLSRKDHQGSNKESHTP----ESTEN------EFLIYEEVT 374

  Fly   381 ----KLYPRPGVFRPIVLIGAPGVGRNELRRRLIARDPEKFRSPVPYTTRPMRTGEVAGREYIFV 441
                :|..:|   |.:||||:.|...|||::::||.:|:::...||:||||.::.|..|.||.|:
Zfish   375 LHQMRLQDKP---RLVVLIGSLGARINELKQKVIAENPQRYGVAVPHTTRPRKSHEKEGVEYHFI 436

  Fly   442 AREKMDADIEAGKFVEHGEYKGHLYGTSAESVKSIVNAGCVCVLSPHYQAIKTLRTAQLKPFLIH 506
            :::..||||::.||:|:||||.:.||||.||::|::....||::....:|:|.|||::.||::|.
Zfish   437 SKQAFDADIQSNKFIEYGEYKNNQYGTSLESIRSVLARNKVCLVDVQPEALKILRTSEFKPYVIF 501

  Fly   507 VKP--PELDILKATRTEARAKSTFDEANARSFTDEEFEDMIKSAERIDFLYGHFFDVELVNGELV 569
            |||  ||:      |....:.::.:..:....|:|:..||..|||:::..|||..|..|:..:..
Zfish   502 VKPRIPEI------RRHRSSPTSPERGDNGHITEEDLLDMKHSAEQMEQQYGHLVDRVLIKEDSA 560

  Fly   570 NAFEQLVQNVQRLENEPVWAPSMWVQ 595
            :|..:|...::|||.||.|.|..||:
Zfish   561 SACVELRLILERLEREPQWVPVSWVR 586

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
metro	NP_610642.2	L27	17..68	CDD:197794	11/53 (21%)
		L27	75..127	CDD:197794	19/51 (37%)
		PDZ_signaling	139..229	CDD:238492	46/89 (52%)
		SH3_MPP	243..302	CDD:212796	32/58 (55%)
		Guanylate_kin	390..575	CDD:279019	70/186 (38%)
		GuKc	399..580	CDD:214504	66/182 (36%)
mpp3b	XP_001340190.2	L27	11..55	CDD:280918	10/46 (22%)
		L27	69..119	CDD:280918	18/50 (36%)
		PDZ_signaling	135..215	CDD:238492	46/89 (52%)
		SH3	230..291	CDD:302595	34/60 (57%)
		Guanylate_kin	383..571	CDD:279019	72/196 (37%)
		GuKc	400..571	CDD:214504	63/176 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594312
Domainoid	1	1.000	89	1.000	Domainoid score	I7808
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	420	1.000	Inparanoid score	I1768
OMA	1	1.010	-	-		QHG49437
OrthoDB	1	1.010	-	-		D245552at33208
OrthoFinder	1	1.000	-	-		FOG0000824
OrthoInspector	1	1.000	-	-		otm24780
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23122
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2258
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	12.010