DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment metro and Dlg5

DIOPT Version :9

Sequence 1:NP_610642.2 Gene:metro / 36176 FlyBaseID:FBgn0050021 Length:595 Species:Drosophila melanogaster
Sequence 2:XP_017171686.1 Gene:Dlg5 / 71228 MGIID:1918478 Length:1931 Species:Mus musculus


Alignment Length:568 Identity:118/568 - (20%)
Similarity:226/568 - (39%) Gaps:128/568 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    80 VLEQLSQHCH-LNDDCKEAFHLLQDSHLQHLLFAHDAI----AQKDFYPHLPEAPVEMDEDEETI 139
            :|.|.:.|.| ||.      |....|||......|..:    |....:|.:.:..:|.||...|.
Mouse  1433 ILAQYNPHIHQLNS------HSRSSSHLDPAATPHSTLQGSSAGTPEHPSVIDPLMEQDEGPGTP 1491

  Fly   140 KIVQLVKSNEPL--TGAQSTEPIVGATIKTDEESGKIIIARIMHG----------GAADRSGLIH 192
            ...|...|...:  |..::.:|.:....|:..:.|..:....:||          .|....||: 
Mouse  1492 PAKQSASSTRSVGDTTKKTPDPRIVFIKKSQLDLGVHLCGGNLHGVFVAEVEDDSPAKGPDGLV- 1555

  Fly   193 VGDEVIEVNNINVEGKTPGDVLTILQNSEGTITFKL------------VPADNKGAQRESKVRVR 245
            .||.::|..::::..:|..||...:...:.::..|:            :|.|:        ..:|
Mouse  1556 PGDLILEYGSLDMRSRTVEDVYVEMLKPKDSLRLKVQYR
HEEFTRVKGLPGDS--------FYIR 1612

  Fly   246 AHFDYNPDVDPYIPCKEAGLAFQRGDVLHIVAQDDAY-------W--WQARKEHERSARAGLIPS 301
            |.:|...:|:|       .|:|::.|:|::   ||..       |  ||. .|:.:..:.|.|||
Mouse  1613 ALYDRLAEVEP-------ELSFKKDDILYV---DDTLPQGVFGSWMAWQL-DENAQKIQRGQIPS 1666

  Fly   302 RALQE----RRILHDRTQKNGTDLDSKPGSCASLCTTPPGSPRLPASSSTSSCRQPKTKKIM--- 359
            :.:.:    ||:.....:.:.|                  :..|.|::..|..|:....|..   
Mouse  1667 KYVMDQEFSRRLSMSEVKDDNT------------------AKTLSAAARRSFFRRKHKHKRSGSK 1713

  Fly   360 --YDLTENDDFDREQIATYEE-VAKLYPRP-----GVFRPIVLIGAPGVGRNELRRRLIARDPEK 416
              .||...|.|..:.|..:|: |:..|.|.     ...||::|:| |.:  :.::..|:...|.|
Mouse  1714 DGKDLLALDTFSNDSIPLFEDSVSLAYQRVQKVDCTSLRPVLLLG-PLL--DVVKEMLVNEAPGK 1775

  Fly   417 F-RSPVPYTTRPMRTGEVAGREYIFVAREKMDADIEAGKFVEHGEYKGHLYGTSAESVKSIV--N 478
            | |.|:               |.:..:::.::..::...||::....||...|:..|:|.|.  |
Mouse  1776 FCRCPL---------------EVMKASQQAIERGVKDCLFVDYKRRSGHFDVTTVASIKEITEKN 1825

  Fly   479 AGCVCVLSPHYQAIKTLRTAQLKPFLIHVKPPELDILKATRTEARAKSTFDEANARSFTDEEFED 543
            ..|:..::||  ||:.|....:.|.:|.::......:|..|.....:....:.:::    |:|| 
Mouse  1826 RHCLLDIAPH--AIERLHHMHIYPIVIFIRYKSAKHIKEQRDPVYLRDKVTQRHSK----EQFE- 1883

  Fly   544 MIKSAERIDFLYGHFFDVELVNGELVNAFEQLVQNVQRLENEPVWAPS 591
               :|::||..|..:|...:..|.|.:...|::..|.:.:::.:|.|:
Mouse  1884 ---TAQKIDQEYSRYFTGVVQGGALSSICTQILAMVSQEQSKVLWIPA 1928

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
metroNP_610642.2 L27 17..68 CDD:197794
L27 75..127 CDD:197794 13/51 (25%)
PDZ_signaling 139..229 CDD:238492 18/113 (16%)
SH3_MPP 243..302 CDD:212796 18/67 (27%)
Guanylate_kin 390..575 CDD:279019 41/187 (22%)
GuKc 399..580 CDD:214504 37/183 (20%)
Dlg5XP_017171686.1 Takusan 129..213 CDD:368141
Smc <141..564 CDD:224117
PDZ_signaling 625..712 CDD:238492
PDZ_signaling <741..800 CDD:238492
PDZ 1357..1439 CDD:214570 2/5 (40%)
dbPDZ_assoc 1437..1512 CDD:374667 18/80 (23%)
PDZ 1513..1594 CDD:214570 15/81 (19%)
SH3_DLG5 1610..1672 CDD:212794 19/72 (26%)
GuKc 1744..1920 CDD:214504 43/203 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0194
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

Return to query results.
Submit another query.