DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment metro and Pdzd2

DIOPT Version :9

Sequence 1:	NP_610642.2	Gene:	metro / 36176	FlyBaseID:	FBgn0050021	Length:	595	Species:	Drosophila melanogaster
Sequence 2:	NP_001074533.1	Gene:	Pdzd2 / 68070	MGIID:	1922394	Length:	2796	Species:	Mus musculus

Alignment Length:	278	Identity:	63/278 - (22%)
Similarity:	103/278 - (37%)	Gaps:	94/278 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LEAVMASDINWDPALSKLISTLKESENLSNDQEIDFLKALLESKELNAL--------------VN 52
            |:||::...:..|.|..:.....:||   |.::|.|:  :|..||.:.|              |.
Mouse  2548 LQAVLSLVGSKSPILPLIQEAKAQSE---NKEDICFI--VLNKKEGSGLGFSVAGGADVEPESVL 2607

  Fly    53 VH--------TKVAKVGRDDRLAPVLSTSAQVL-----YEVLEQLSQHCHL-------NDDCKEA 97
            ||        ::...|.:.|.|..|..||...|     .:||.|...|.|:       ||..:.:
Mouse  2608 VHRVFSQGVASQEGTVSQGDFLLSVNGTSLAGLSHSEVTKVLHQAELHKHVLMIIKKGNDQPRPS 2672

  Fly    98 FHLLQDSHLQHLLF----------------AHDAIAQKDFYPHLPEAPVEMDEDEETIKIVQLVK 146
            |.....|......|                ||||:.                        |:::|
Mouse  2673 FRQEPPSANGKAPFPRRTLPLEPGAGRNGAAHDALC------------------------VEVLK 2713

  Fly   147 SNE----PLTGAQSTEPIVGATIKTDEESGKIIIARIMHGGAADRSGLIHVGDEVIEVNNINVEG 207
            ::.    .|.|.:|:  |.|        .|.::|.|:..||||:::|.|..|||::.:|...:.|
Mouse  2714 TSAGLGLSLDGGKSS--IAG--------DGPLVIKRVYQGGAAEQAGTIEAGDEILAINGKPLVG 2768

  Fly   208 KTPGDVLTILQN-SEGTI 224
            ....|...|::: .||.:
Mouse  2769 LVHFDAWNIMKSVPEGPV 2786

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
metro	NP_610642.2	L27	17..68	CDD:197794	15/72 (21%)
		L27	75..127	CDD:197794	15/79 (19%)
		PDZ_signaling	139..229	CDD:238492	25/91 (27%)
		SH3_MPP	243..302	CDD:212796
		Guanylate_kin	390..575	CDD:279019
		GuKc	399..580	CDD:214504
Pdzd2	NP_001074533.1	PDZ_signaling	335..416	CDD:238492
		PDZ_signaling	591..672	CDD:238492
		PDZ_signaling	729..813	CDD:238492
		PHA03307	1050..>1355	CDD:223039
		PHA03247	<1197..1562	CDD:223021
		PDZ_signaling	2581..2663	CDD:238492	19/83 (23%)
		PDZ	2709..2791	CDD:214570	25/88 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900