Protein Alignment metro and PALS1

DIOPT Version :10

• Sequence 1: NP_610642.2
• Gene: metro / 36176
• FlyBaseID: FBgn0050021
• Length: 595
• Species: Drosophila melanogaster
• Sequence 2: NP_071919.2
• Gene: PALS1 / 64398
• HGNCID: 18669
• Length: 675
• Species: Homo sapiens
• Alignment Length: 603
• Identity: 213/603 - (35%)
• Similarity: 350/603 - (58%)
• Gaps: 74/603 - (12%)

  Fly    16 LSKLISTLKESENL----SNDQEIDFLKALLESKELNALVNVHTKV-AKVGRDDRLAPVLSTSAQ 75
            :..|.|:||..::.    .:.::|..|..|:::|:......:|..: ..:.:.....|::|.:..
Human   124 IEDLFSSLKHIQHTLVDSQSQEDISLLLQLVQNKDFQNAFKIHNAITVHMNKASPPFPLISNAQD 188

  Fly    76 VLYEVLEQLSQHCHLNDDCKEAFHLLQDSHLQHLLFAHDAIAQKDFYPHLPEAPVEMDEDE---- 136
            :..||...|....|  .:.:|...||...|:|.||.|||.:|::       |..:|...||
Human   189 LAQEVQTVLKPVHH--KEGQELTALLNTPHIQALLLAHDKVAEQ-------EMQLEPITDERVYE 244

  Fly   137 -------ETIKIVQLVKSNE-PLTGAQSTEPIVGATIKTDEESGKIIIARIMHGGAADRSGLIHV 193
                   ||:|||::.|:.: ||          |||::.:.:|  :||:||:.||||::|||:|.
Human   245 SIGQYGGETVKIVRIEKARDIPL----------GATVRNEMDS--VIISRIVKGGAAEKSGLLHE 297

  Fly   194 GDEVIEVNNINVEGKTPGDVLTILQNSEGTITFKLVPAD--NKGAQRESKVRVRAHFDYNPDVDP 256
            ||||:|:|.|.:.||...:|..:|.:..||:||.|:|:.  .....:|:.:.|:|||||:|..||
Human   298 GDEVLEINGIEIRGKDVNEVFDLLSDMHGTLTFVLIPSQQIKPPPAKETVIHVKAHFDYDPSDDP 362

  Fly   257 YIPCKEAGLAFQRGDVLHIVAQDDAYWWQARKE--HERSARAGLIPSRALQERRILHDRTQKNGT 319
            |:||:|.||:||:||:||:::|:|..||||.:|  .:....|||:|.::.|::|    ...|...
Human   363 YVPCRELGLSFQKGDILHVISQEDPNWWQAYREGDEDNQPLAGLVPGKSFQQQR----EAMKQTI 423

  Fly   320 DLDSKPGSCASL-CTTPPGSPRLPASSSTSSCRQPKTKKIMYDLTENDDFDREQIATYEEVAKLY 383
            :.|.:|.....| |               :...:.|.||::|:..:|||:|.|:|.||||:: ||
Human   424 EEDKEPEKSGKLWC---------------AKKNKKKRKKVLYNANKNDDYDNEEILTYEEMS-LY 472

  Fly   384 PRP-GVFRPIVLIGAPGVGRNELRRRLIARDPEKFRSPVPYTTRPMRTGEVAGREYIFVAREKMD 447
            .:| ...|||:|||....|:||||:||:.::.::|.|.||:|||..|..|||||:|.||:|:..:
Human   473 HQPANRKRPIILIGPQNCGQNELRQRLMNKEKDRFASAVPHTTRSRRDQEVAGRDYHFVSRQAFE 537

  Fly   448 ADIEAGKFVEHGEYKGHLYGTSAESVKSIVNAGCVCVLSPHYQAIKTLRTAQLKPFLIHVKPPEL 512
            |||.||||:||||::.:|||||.:||:.::|:|.:|:||...|::||||.:.|||::|.:.||..
Human   538 ADIAAGKFIEHGEFEKNLYGTSIDSVRQVINSGKICLLSLRTQSLKTLRNSDLKPYIIFIAPPSQ 602

  Fly   513 DILKATRTEARAKSTFDEANARSFTDEEFEDMIKSAERIDFLYGHFFDVELVNGELVNAFEQLVQ 577
            :.|:|...:          ..::...||..::|:....::...||:||..:||.:|..|:::|::
Human   603 ERLRALLAK----------EGKNPKPEELREIIEKTREMEQNNGHYFDTAIVNSDLDKAYQELLR 657

  Fly   578 NVQRLENEPVWAPSMWVQ 595
            .:.:|:.||.|.||.|::
Human   658 LINKLDTEPQWVPSTWLR 675

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
metro	NP_610642.2	L27	17..68	CDD:197794	9/55 (16%)
		L27	75..127	CDD:197794	15/51 (29%)
		PDZ_MPP3-MPP4-MPP7-like	140..230	CDD:467260	38/90 (42%)
		SH3_MPP	243..302	CDD:212796	32/60 (53%)
		Guanylate_kin	390..575	CDD:395500	77/184 (42%)
PALS1	NP_071919.2	Required for the correct localization of PALS1 and PATJ at cell-cell contacts and the normal formation of tight junctions and adherens junctions. /evidence=ECO:0000250|UniProtKB:Q9JLB2	1..345		71/241 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..34
		Interaction with PARD6B. /evidence=ECO:0000250|UniProtKB:Q9JLB2	21..140		4/15 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	51..78
		L27_N	123..170	CDD:462666	9/45 (20%)
		Interaction with LIN7C. /evidence=ECO:0000250|UniProtKB:Q9JLB2	181..243		21/70 (30%)
		L27	189..237	CDD:197794	17/56 (30%)
		PDZ_MPP5-like	255..334	CDD:467259	38/90 (42%)
		SH3_MPP5	349..411	CDD:212969	32/61 (52%)
		GuKc	491..661	CDD:214504	72/179 (40%)