DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment metro and Dlg3

DIOPT Version :9

Sequence 1:	NP_610642.2	Gene:	metro / 36176	FlyBaseID:	FBgn0050021	Length:	595	Species:	Drosophila melanogaster
Sequence 2:	XP_006257142.1	Gene:	Dlg3 / 58948	RGDID:	68423	Length:	867	Species:	Rattus norvegicus

Alignment Length:	603	Identity:	167/603 - (27%)
Similarity:	274/603 - (45%)	Gaps:	105/603 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 HTKVAKVGRDDRLAPVLSTSAQVLYEVLEQLSQHCHLND-----DCKEAFHLLQDSHLQH--LLF 111
            :|.:..|..::.:|.:.:||..|..:|.:..|  .||||     |....|..|.|:|:.|  .|.
  Rat   301 NTNLQDVRHEEAVASLKNTSDMVYLKVAKPGS--LHLNDMYAPPDYASTFTALADNHISHNSSLG 363

  Fly   112 AHDAIAQKDFYPHLPEAP------------VEMDEDEETIKIVQLVKSNEPLTGAQSTEPIVGAT 164
            ...|:..|..||..|:.|            .|.|...|..||: |.|.:   ||       :|..
  Rat   364 YLGAVESKVTYPAPPQVPPTRYSPIPRHMLAEEDFTREPRKII-LHKGS---TG-------LGFN 417

  Fly   165 IKTDEESGKIIIARIMHGGAADRSGLIHVGDEVIEVNNINVEGKTPGDVLTILQNSEGTITFKLV 229
            |...|:...|.::.|:.||.||.||.:..||.::.||.:|:...|.......|:.:..::|....
  Rat   418 IVGGEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQSVTIVAQ 482

  Fly   230 PADNKGAQRESKVR---------------------------VRAHFDYNPDVDPYIPCKEAGLAF 267
            ....:.::.|||:.                           |||.|||:...|..:|.:  ||:|
  Rat   483 YRPEEYSRFESKIHDLREQMMNSSMSSGSGSLRTSEKRSLYVRALFDYDRTRDSCLPSQ--GLSF 545

  Fly   268 QRGDVLHIVAQDDAYWWQAR--KEHERSARAGLIPSRALQERRILHDRTQKNGTDLDSKPG---S 327
            ..||:||::...|..|||||  ..|..|.:.|:|||:...|::   :|.:.......::.|   |
  Rat   546 SYGDILHVINASDDEWWQARLVTPHGESEQIGVIPSKKRVEKK---ERARLKTVKFHARTGMIES 607

  Fly   328 CASLCTTPPGSPRL----PASSSTSSCRQPKT---KKIMYDLTENDDFDREQ---IATYEEVAKL 382
            ..|:.|....|.||    |...|..:..|.|:   :.:..:.::::...:.|   |.:||.|.:.
  Rat   608 NRSIKTKRKKSFRLSRKFPFYKSKENMAQEKSIQEQGVTSNTSDSESSSKGQEDAILSYEPVTRQ 672

  Fly   383 ---YPRPGVFRPIVLIGAPGVGRNELRRRLIARDPEKFRSPVPYTTRPMRTGEVAGREYIF-VAR 443
               |.     ||::::|..   ::.:...||:..|.||.|.||:||||.|..||.|::|.| |:|
  Rat   673 EIHYA-----RPVIILGPM---KDRVNDDLISEFPHKFGSCVPHTTRPRRDNEVDGQDYHFVVSR 729

  Fly   444 EKMDADIEAGKFVEHGEYKGHLYGTSAESVKSIVNAGCVCVLSPHYQAIKTLRTAQLKPFLIHVK 508
            |:|:.||:..||:|.|::..:|||||.:||:::...|..|:|.....|||.|:.|||.|..|.:|
  Rat   730 EQMEKDIQDNKFIEAGQFNDNLYGTSIQSVRAVAERGKHCILDVSGNAIKRLQQAQLYPIAIFIK 794

  Fly   509 PPELDILKATRTEARAKSTFDEANARSFTDEEFEDMIKSAERIDFLYGHFFDVELVNGELVNAFE 573
            |..::.|    .|...:.|:::||          .:...|.:::..:|.:|...:....|...:.
  Rat   795 PKSIEAL----MEMNRRQTYEQAN----------KIFDKAMKLEQEFGEYFTAIVQGDSLEEIYN 845

  Fly   574 QLVQNVQRLENEPVWAPS 591
            ::.|.::......:|.||
  Rat   846 KIKQIIEDQSGHYIWVPS 863

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
metro	NP_610642.2	L27	17..68	CDD:197794	2/13 (15%)
		L27	75..127	CDD:197794	18/58 (31%)
		PDZ_signaling	139..229	CDD:238492	25/89 (28%)
		SH3_MPP	243..302	CDD:212796	26/87 (30%)
		Guanylate_kin	390..575	CDD:279019	61/185 (33%)
		GuKc	399..580	CDD:214504	59/181 (33%)
Dlg3	XP_006257142.1	MAGUK_N_PEST	52..148	CDD:287565
		PDZ_signaling	149..226	CDD:238492
		PDZ_signaling	242..328	CDD:238492	6/26 (23%)
		PDZ_assoc	329..403	CDD:287558	21/75 (28%)
		PDZ_signaling	402..480	CDD:238492	25/88 (28%)
		SH3_DLG3	520..586	CDD:212962	27/67 (40%)
		Guanylate_kin	676..854	CDD:279019	63/199 (32%)
		GuKc	687..854	CDD:214504	59/180 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810