DRSC/TRiP Functional Genomics Resources

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Protein Alignment metro and MPP4

DIOPT Version :9

Sequence 1:NP_610642.2 Gene:metro / 36176 FlyBaseID:FBgn0050021 Length:595 Species:Drosophila melanogaster
Sequence 2:NP_149055.2 Gene:MPP4 / 58538 HGNCID:13680 Length:637 Species:Homo sapiens


Alignment Length:647 Identity:230/647 - (35%)
Similarity:348/647 - (53%) Gaps:92/647 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 MASDINWDPALSKLISTLKESENLSNDQEID---FLKALLESKELNALVNVHTKVAKVGRDDRLA 67
            :::..|....||:::..:.:..:|...::::   .|..||.|..|.||:.::..:.:. ::.:|.
Human    18 LSTATNPQNGLSQILRLVLQELSLFYGRDVNGVCLLYDLLHSPWLQALLKIYDCLQEF-KEKKLV 81

  Fly    68 PVLSTSAQVL-YEVLEQLSQHCHLNDDCKEAFHLLQDSHLQHLLFAHDAIAQKDFYPHLPEAPVE 131
            |. :..|||| |||:| |.:....:.:.:|...:||..|.:.||.|||.||||||.|.||..|..
Human    82 PA-TPHAQVLSYEVVE-LLRETPTSPEIQELRQMLQAPHFKALLSAHDTIAQKDFEPLLPPLPDN 144

  Fly   132 MDEDEETIKIVQLVKSNEPLTGAQSTEPIVGATIKTDEESGKIIIARIMHGGAADRSGLIHVGDE 196
            :.|.||.::||.|||:.:||          |||||..|.:|.|::|||:|||.|:||||::.||:
Human   145 IPESEEAMRIVCLVKNQQPL----------GATIKRHEMTGDILVARIIHGGLAERSGLLYAGDK 199

  Fly   197 VIEVNNINVEGKTPGDVLTILQNSEGTITFKLVPADNKGAQRESKVRVRAHFDYNPDVDPYIPCK 261
            ::|||.::|||..|..|:.||..|.|||.||:||..:.....:..|.|||..:|.|..||.|||.
Human   200 LVEVNGVSVEGLDPEQVIHILAMSRGTIMFKVVPVSDPPVNSQQMVYVRAMTEYWPQEDPDIPCM 264

  Fly   262 EAGLAFQRGDVLHIVAQDDAYWWQARKEHERSARAGLIPSRALQERRILHDRTQKNGTDLDSKPG 326
            :|||.||:||:|.||.|:||.||||||..:.:..|||:||..|.:|:      |:          
Human   265 DAGLPFQKGDILQIVDQNDALWWQARKISDPATCAGLVPSNHLLKRK------QR---------- 313

  Fly   327 SCASLCTTPPGSPRLPASSSTS-SCRQPKTKKIMYDLTENDD--FDREQI--------------- 373
               ....:.|..|.....|:.| |..:....||.....|.|:  |:.|::               
Human   314 ---EFWWSQPYQPHTCLKSTLSISMEEEDDMKIDEKCVEADEETFESEELSEDKEEFVGYGQKFF 375

  Fly   374 -----------------------------------ATYEEVAKLYPRPG-VFRPIVLIGAPGVGR 402
                                               |.||||.:...||. .:|.|||:|..|||.
Human   376 IAGFRRSMRLCRRKSHLSPLHASVCCTGSCYSAVGAPYEEVVRYQRRPSDKYRLIVLMGPSGVGV 440

  Fly   403 NELRRRLIARDPEKFRSPVPYTTRPMRTGEVAGREYIFVAREKMDADIEAGKFVEHGEYKGHLYG 467
            |||||:||..:|..|:|.||:|||..::.|:.||||.:|::|..:..|.:.:.:|:|||||||||
Human   441 NELRRQLIEFNPSHFQSAVPHTTRTKKSYEMNGREYHYVSKETFENLIYSHRMLEYGEYKGHLYG 505

  Fly   468 TSAESVKSIVNAGCVCVLSPHYQAIKTLRTAQLKPFLIHVKPPELDILKATRTEARAKSTFDEAN 532
            ||.::|::::..|.:||:....|.|:.:||.:|||::|.:||..:..:|.:|  ..||...|...
Human   506 TSVDAVQTVLVEGKICVMDLEPQDIQGVRTHELKPYVIFIKPSNMRCMKQSR--KNAKVITDYYV 568

  Fly   533 ARSFTDEEFEDMIKSAERIDFLYGHFFDVELVNGELVNAFEQLVQNVQRLENEPVWAPSMWV 594
            ...|.||:.::|...|:|::..:|.|||..:||..|.:|..||:..:|:.:.||.|.|:.|:
Human   569 DMKFKDEDLQEMENLAQRMETQFGQFFDHVIVNDSLHDACAQLLSAIQKAQEEPQWVPATWI 630

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
metroNP_610642.2 L27 17..68 CDD:197794 10/53 (19%)
L27 75..127 CDD:197794 25/52 (48%)
PDZ_signaling 139..229 CDD:238492 44/89 (49%)
SH3_MPP 243..302 CDD:212796 33/58 (57%)
Guanylate_kin 390..575 CDD:279019 76/184 (41%)
GuKc 399..580 CDD:214504 73/180 (41%)
MPP4NP_149055.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..22 0/3 (0%)
L27 30..83 CDD:197794 9/53 (17%)
L27 90..140 CDD:197794 23/50 (46%)
PDZ_signaling 153..232 CDD:238492 44/88 (50%)
SH3_MPP4 246..306 CDD:212967 34/59 (58%)
Guanylate_kin 428..618 CDD:331880 79/191 (41%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165158382
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0194
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S2832
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D245552at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm41189
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR23122
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
98.760

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