Protein Alignment metro and MPP4

DIOPT Version :10

• Sequence 1: NP_610642.2
• Gene: metro / 36176
• FlyBaseID: FBgn0050021
• Length: 595
• Species: Drosophila melanogaster
• Sequence 2: NP_149055.2
• Gene: MPP4 / 58538
• HGNCID: 13680
• Length: 637
• Species: Homo sapiens
• Alignment Length: 647
• Identity: 230/647 - (35%)
• Similarity: 348/647 - (53%)
• Gaps: 92/647 - (14%)

  Fly     6 MASDINWDPALSKLISTLKESENLSNDQEID---FLKALLESKELNALVNVHTKVAKVGRDDRLA 67
            :::..|....||:::..:.:..:|...::::   .|..||.|..|.||:.::..:.:. ::.:|.
Human    18 LSTATNPQNGLSQILRLVLQELSLFYGRDVNGVCLLYDLLHSPWLQALLKIYDCLQEF-KEKKLV 81

  Fly    68 PVLSTSAQVL-YEVLEQLSQHCHLNDDCKEAFHLLQDSHLQHLLFAHDAIAQKDFYPHLPEAPVE 131
            |. :..|||| |||:| |.:....:.:.:|...:||..|.:.||.|||.||||||.|.||..|..
Human    82 PA-TPHAQVLSYEVVE-LLRETPTSPEIQELRQMLQAPHFKALLSAHDTIAQKDFEPLLPPLPDN 144

  Fly   132 MDEDEETIKIVQLVKSNEPLTGAQSTEPIVGATIKTDEESGKIIIARIMHGGAADRSGLIHVGDE 196
            :.|.||.::||.|||:.:||          |||||..|.:|.|::|||:|||.|:||||::.||:
Human   145 IPESEEAMRIVCLVKNQQPL----------GATIKRHEMTGDILVARIIHGGLAERSGLLYAGDK 199

  Fly   197 VIEVNNINVEGKTPGDVLTILQNSEGTITFKLVPADNKGAQRESKVRVRAHFDYNPDVDPYIPCK 261
            ::|||.::|||..|..|:.||..|.|||.||:||..:.....:..|.|||..:|.|..||.|||.
Human   200 LVEVNGVSVEGLDPEQVIHILAMSRGTIMFKVVPVSDPPVNSQQMVYVRAMTEYWPQEDPDIPCM 264

  Fly   262 EAGLAFQRGDVLHIVAQDDAYWWQARKEHERSARAGLIPSRALQERRILHDRTQKNGTDLDSKPG 326
            :|||.||:||:|.||.|:||.||||||..:.:..|||:||..|.:|:      |:
Human   265 DAGLPFQKGDILQIVDQNDALWWQARKISDPATCAGLVPSNHLLKRK------QR---------- 313

  Fly   327 SCASLCTTPPGSPRLPASSSTS-SCRQPKTKKIMYDLTENDD--FDREQI--------------- 373
               ....:.|..|.....|:.| |..:....||.....|.|:  |:.|::
Human   314 ---EFWWSQPYQPHTCLKSTLSISMEEEDDMKIDEKCVEADEETFESEELSEDKEEFVGYGQKFF 375

  Fly   374 -----------------------------------ATYEEVAKLYPRPG-VFRPIVLIGAPGVGR 402
                                               |.||||.:...||. .:|.|||:|..|||.
Human   376 IAGFRRSMRLCRRKSHLSPLHASVCCTGSCYSAVGAPYEEVVRYQRRPSDKYRLIVLMGPSGVGV 440

  Fly   403 NELRRRLIARDPEKFRSPVPYTTRPMRTGEVAGREYIFVAREKMDADIEAGKFVEHGEYKGHLYG 467
            |||||:||..:|..|:|.||:|||..::.|:.||||.:|::|..:..|.:.:.:|:|||||||||
Human   441 NELRRQLIEFNPSHFQSAVPHTTRTKKSYEMNGREYHYVSKETFENLIYSHRMLEYGEYKGHLYG 505

  Fly   468 TSAESVKSIVNAGCVCVLSPHYQAIKTLRTAQLKPFLIHVKPPELDILKATRTEARAKSTFDEAN 532
            ||.::|::::..|.:||:....|.|:.:||.:|||::|.:||..:..:|.:|  ..||...|...
Human   506 TSVDAVQTVLVEGKICVMDLEPQDIQGVRTHELKPYVIFIKPSNMRCMKQSR--KNAKVITDYYV 568

  Fly   533 ARSFTDEEFEDMIKSAERIDFLYGHFFDVELVNGELVNAFEQLVQNVQRLENEPVWAPSMWV 594
            ...|.||:.::|...|:|::..:|.|||..:||..|.:|..||:..:|:.:.||.|.|:.|:
Human   569 DMKFKDEDLQEMENLAQRMETQFGQFFDHVIVNDSLHDACAQLLSAIQKAQEEPQWVPATWI 630

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
metro	NP_610642.2	L27	17..68	CDD:197794	10/53 (19%)
		L27	75..127	CDD:197794	25/52 (48%)
		PDZ_MPP3-MPP4-MPP7-like	140..230	CDD:467260	44/89 (49%)
		SH3_MPP	243..302	CDD:212796	33/58 (57%)
		Guanylate_kin	390..575	CDD:395500	76/184 (41%)
MPP4	NP_149055.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..22		0/3 (0%)
		L27	30..83	CDD:197794	9/53 (17%)
		L27	90..140	CDD:197794	23/50 (46%)
		PDZ_MPP3-MPP4-MPP7-like	153..233	CDD:467260	44/89 (49%)
		SH3_MPP4	246..306	CDD:212967	34/59 (58%)
		Guanylate_kin	428..618	CDD:395500	79/191 (41%)