DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment metro and mpp3a

DIOPT Version :9

Sequence 1:	NP_610642.2	Gene:	metro / 36176	FlyBaseID:	FBgn0050021	Length:	595	Species:	Drosophila melanogaster
Sequence 2:	XP_021330373.1	Gene:	mpp3a / 572079	ZFINID:	ZDB-GENE-130530-555	Length:	613	Species:	Danio rerio

Alignment Length:	646	Identity:	233/646 - (36%)
Similarity:	358/646 - (55%)	Gaps:	85/646 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLEA--VMASDINWDPALSKLISTLKESENLSNDQEIDFLKALLESKELNALVNVHTKVAKVGRD 63
            |.||  |:::.......|:.|.|.|:...|  :.:::.||:.:...:.|:.|:.:|.|:.:..:.
Zfish     1 MKEAMPVLSAGGGLHETLALLTSQLRPDAN--HKEDMVFLRDVFSERSLSCLMKIHEKLRQYEKQ 63

  Fly    64 DRLAPVLSTSAQVLYEVLEQLSQHCHLNDDCKEAFHLLQDSHLQHLLFAHDAIAQKDFYPHLPEA 128
            .. .|||.:::.:..:|.|:| |...::.:.||..|||...||:.:|..||.:|||:|.|.||..
Zfish    64 SP-TPVLHSASTLAEDVAEEL-QSGPMSVEEKELLHLLTSPHLKAVLSVHDTVAQKNFDPVLPPL 126

  Fly   129 PVEMDE--DEETIKIVQLVKSNEPLTGAQSTEPIVGATIKTDEESGKIIIARIMHGGAADRSGLI 191
            |.:.::  |||::|||:|||:.|||          ||||:.||.:|.:|:||||.|||||||||:
Zfish   127 PDDFEDELDEESVKIVRLVKNKEPL----------GATIRRDESTGAVIVARIMKGGAADRSGLV 181

  Fly   192 HVGDEVIEVNNINVEGKTPGDVLTILQNSEGTITFKLVPA-DNKGAQRESKVRVRAHFDYNPDVD 255
            |||||:.|||..:|..|.|.::..:|..|:|:||.|::|| ..:...:|:||.:||.|||.|..|
Zfish   182 HVGDELREVNGSSVMHKRPDEISQLLSQSQGSITLKIIPAIKEEDKLQENKVYMRALFDYTPLED 246

  Fly   256 PYIPCKEAGLAFQRGDVLHIVAQDDAYWWQARKEHERSARAGLIPSRALQERRILHDRTQKNGTD 320
            ...||:||||.|:|||||.:|:|||..||||::..:.:.||||:||:..||||:.:  ..|.||.
Zfish   247 KATPCQEAGLPFKRGDVLQVVSQDDQTWWQAKRIGDCNLRAGLVPSKQFQERRLAY--RIKMGTL 309

  Fly   321 LDSKPGSCASLCTTPPGSPRLPASSS-------------------TSSCR--QPKTKKIM----- 359
            .:||             ||:......                   :|.|.  .|...::.
Zfish   310 QNSK-------------SPKKAVYDQGCDKEDCDCEGYFNGQYIVSSKCNAVAPSCGQVFSWDFY 361

  Fly   360 -------YDLTEND-----------DFDREQIATYEEVAKLYPRPGVFRP--IVLIGAPGVGRNE 404
                   :.|:..|           |.:.....|||||.: |.:....||  :||||:.|...||
Zfish   362 SAGLRRSFRLSRKDRRGSSGEANVSDQNDTDFLTYEEVTR-YQQRSNERPRLVVLIGSLGARINE 425

  Fly   405 LRRRLIARDPEKFRSPVPYTTRPMRTGEVAGREYIFVAREKMDADIEAGKFVEHGEYKGHLYGTS 469
            |::::||.:|.::...||:||||.::.|..|.||.||.::..|||.:..||:|:||||.:|||||
Zfish   426 LKQKVIAENPHRYAVAVPHTTRPKKSHEKEGVEYHFVTKQAFDADAQNNKFIEYGEYKENLYGTS 490

  Fly   470 AESVKSIVNAGCVCVLSPHYQAIKTLRTAQLKPFLIHVKPPELDILKATRTEARAKSTFDEANAR 534
            .|:::|:.....:|::....:|:|.||||:.||::|.|||   .|.::.|..:.|.|.....:.|
Zfish   491 IEAIRSVQAKNKMCLVDVQPEALKALRTAEFKPYVIFVKP---KIPESRRRRSAATSPGGGEHGR 552

  Fly   535 SFTDEEFEDMIKSAERIDFLYGHFFDVELVNGELVNAFEQLVQNVQRLENEPVWAPSMWVQ 595
             .|:|:.::|..||::||..|||..|..|:..:..:|..:|...::|||.|..|.|..||:
Zfish   553 -ITEEDLQEMRLSAQQIDQQYGHLVDRVLIKEDTASASTELRSILERLERETFWVPISWVR 612

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
metro	NP_610642.2	L27	17..68	CDD:197794	10/50 (20%)
		L27	75..127	CDD:197794	20/51 (39%)
		PDZ_signaling	139..229	CDD:238492	47/89 (53%)
		SH3_MPP	243..302	CDD:212796	32/58 (55%)
		Guanylate_kin	390..575	CDD:279019	73/186 (39%)
		GuKc	399..580	CDD:214504	68/180 (38%)
mpp3a	XP_021330373.1	L27	15..66	CDD:308467	11/53 (21%)
		L27	73..123	CDD:308467	19/50 (38%)
		PDZ_signaling	139..219	CDD:238492	47/89 (53%)
		SH3	234..295	CDD:327375	33/60 (55%)
		GuKc	426..597	CDD:214504	65/174 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594311
Domainoid	1	1.000	94	1.000	Domainoid score	I7412
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	420	1.000	Inparanoid score	I1768
OMA	1	1.010	-	-		QHG49437
OrthoDB	1	1.010	-	-		D245552at33208
OrthoFinder	1	1.000	-	-		FOG0000824
OrthoInspector	1	1.000	-	-		otm24780
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23122
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2258
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.910