Protein Alignment metro and mpp3a

DIOPT Version :10

• Sequence 1: NP_610642.2
• Gene: metro / 36176
• FlyBaseID: FBgn0050021
• Length: 595
• Species: Drosophila melanogaster
• Sequence 2: XP_021330373.1
• Gene: mpp3a / 572079
• ZFINID: ZDB-GENE-130530-555
• Length: 613
• Species: Danio rerio
• Alignment Length: 646
• Identity: 233/646 - (36%)
• Similarity: 358/646 - (55%)
• Gaps: 85/646 - (13%)

  Fly     1 MLEA--VMASDINWDPALSKLISTLKESENLSNDQEIDFLKALLESKELNALVNVHTKVAKVGRD 63
            |.||  |:::.......|:.|.|.|:...|  :.:::.||:.:...:.|:.|:.:|.|:.:..:.
Zfish     1 MKEAMPVLSAGGGLHETLALLTSQLRPDAN--HKEDMVFLRDVFSERSLSCLMKIHEKLRQYEKQ 63

  Fly    64 DRLAPVLSTSAQVLYEVLEQLSQHCHLNDDCKEAFHLLQDSHLQHLLFAHDAIAQKDFYPHLPEA 128
            .. .|||.:::.:..:|.|:| |...::.:.||..|||...||:.:|..||.:|||:|.|.||..
Zfish    64 SP-TPVLHSASTLAEDVAEEL-QSGPMSVEEKELLHLLTSPHLKAVLSVHDTVAQKNFDPVLPPL 126

  Fly   129 PVEMDE--DEETIKIVQLVKSNEPLTGAQSTEPIVGATIKTDEESGKIIIARIMHGGAADRSGLI 191
            |.:.::  |||::|||:|||:.|||          ||||:.||.:|.:|:||||.|||||||||:
Zfish   127 PDDFEDELDEESVKIVRLVKNKEPL----------GATIRRDESTGAVIVARIMKGGAADRSGLV 181

  Fly   192 HVGDEVIEVNNINVEGKTPGDVLTILQNSEGTITFKLVPA-DNKGAQRESKVRVRAHFDYNPDVD 255
            |||||:.|||..:|..|.|.::..:|..|:|:||.|::|| ..:...:|:||.:||.|||.|..|
Zfish   182 HVGDELREVNGSSVMHKRPDEISQLLSQSQGSITLKIIPAIKEEDKLQENKVYMRALFDYTPLED 246

  Fly   256 PYIPCKEAGLAFQRGDVLHIVAQDDAYWWQARKEHERSARAGLIPSRALQERRILHDRTQKNGTD 320
            ...||:||||.|:|||||.:|:|||..||||::..:.:.||||:||:..||||:.:  ..|.||.
Zfish   247 KATPCQEAGLPFKRGDVLQVVSQDDQTWWQAKRIGDCNLRAGLVPSKQFQERRLAY--RIKMGTL 309

  Fly   321 LDSKPGSCASLCTTPPGSPRLPASSS-------------------TSSCR--QPKTKKIM----- 359
            .:||             ||:......                   :|.|.  .|...::.
Zfish   310 QNSK-------------SPKKAVYDQGCDKEDCDCEGYFNGQYIVSSKCNAVAPSCGQVFSWDFY 361

  Fly   360 -------YDLTEND-----------DFDREQIATYEEVAKLYPRPGVFRP--IVLIGAPGVGRNE 404
                   :.|:..|           |.:.....|||||.: |.:....||  :||||:.|...||
Zfish   362 SAGLRRSFRLSRKDRRGSSGEANVSDQNDTDFLTYEEVTR-YQQRSNERPRLVVLIGSLGARINE 425

  Fly   405 LRRRLIARDPEKFRSPVPYTTRPMRTGEVAGREYIFVAREKMDADIEAGKFVEHGEYKGHLYGTS 469
            |::::||.:|.::...||:||||.::.|..|.||.||.::..|||.:..||:|:||||.:|||||
Zfish   426 LKQKVIAENPHRYAVAVPHTTRPKKSHEKEGVEYHFVTKQAFDADAQNNKFIEYGEYKENLYGTS 490

  Fly   470 AESVKSIVNAGCVCVLSPHYQAIKTLRTAQLKPFLIHVKPPELDILKATRTEARAKSTFDEANAR 534
            .|:::|:.....:|::....:|:|.||||:.||::|.|||   .|.::.|..:.|.|.....:.|
Zfish   491 IEAIRSVQAKNKMCLVDVQPEALKALRTAEFKPYVIFVKP---KIPESRRRRSAATSPGGGEHGR 552

  Fly   535 SFTDEEFEDMIKSAERIDFLYGHFFDVELVNGELVNAFEQLVQNVQRLENEPVWAPSMWVQ 595
             .|:|:.::|..||::||..|||..|..|:..:..:|..:|...::|||.|..|.|..||:
Zfish   553 -ITEEDLQEMRLSAQQIDQQYGHLVDRVLIKEDTASASTELRSILERLERETFWVPISWVR 612

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
metro	NP_610642.2	L27	17..68	CDD:197794	10/50 (20%)
		L27	75..127	CDD:197794	20/51 (39%)
		PDZ_MPP3-MPP4-MPP7-like	140..230	CDD:467260	47/89 (53%)
		SH3_MPP	243..302	CDD:212796	32/58 (55%)
		Guanylate_kin	390..575	CDD:395500	73/186 (39%)
mpp3a	XP_021330373.1	L27	15..66	CDD:460717	11/53 (21%)
		L27	73..123	CDD:460717	19/50 (38%)
		PDZ_MPP3-MPP4-MPP7-like	140..220	CDD:467260	47/89 (53%)
		SH3	234..295	CDD:473055	33/60 (55%)
		GuKc	426..597	CDD:214504	65/174 (37%)