DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment metro and Pals2

DIOPT Version :9

Sequence 1:	NP_610642.2	Gene:	metro / 36176	FlyBaseID:	FBgn0050021	Length:	595	Species:	Drosophila melanogaster
Sequence 2:	NP_001158205.1	Gene:	Pals2 / 56524	MGIID:	1927340	Length:	553	Species:	Mus musculus

Alignment Length:	603	Identity:	211/603 - (34%)
Similarity:	328/603 - (54%)	Gaps:	75/603 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LSKLISTLKESENLSNDQEID--FLKALLESKELNALVNVHTKVAKVGRDDRLAPVLSTSAQVLY 78
            :.:::..|.|..:.:..:|||  |||.::|:..:.:|...|.::    .|.:|..|...:.:::.
Mouse     1 MQQVLENLTELPSSTGAEEIDLIFLKGIMENPIVKSLAKAHERL----EDSKLEAVSDNNLELVN 61

  Fly    79 EVLEQLSQHCHLNDDCKEAFHLLQDSHLQHLLFAHDAIAQK--DFYPHLPEAPVEMDEDEETIKI 141
            |:||.::....::::..|...:|::.|.|.||.|||.:|.|  |..|..||..:....::..:..
Mouse    62 EILEDITPLISVDENVAELVGILKEPHFQSLLEAHDIVASKCYDSPPSSPEMNIPSLNNQLPVDA 126

  Fly   142 VQLV----KSNEPLTGAQSTEPIVGATIKTDEESGKIIIARIMHGGAADRSGLIHVGDEVIEVNN 202
            ::::    |:.|||          |.|.:.  |:..::||||:|||..||.||:||||.:.|||.
Mouse   127 IRILGIHKKAGEPL----------GVTFRV--ENNDLVIARILHGGMIDRQGLLHVGDIIKEVNG 179

  Fly   203 INVEGKTPGDVLTILQNSEGTITFKLVPA--DNKGAQRE-----------SKVRVRAHFDYNPDV 254
            ..| |..|.::..:|:|..|::|.|::|:  |....|:.           .:|.|:.||||||..
Mouse   180 HEV-GNNPKELQELLKNISGSVTLKILPSYRDTITPQQSYVNMERHPAHVRQVFVKCHFDYNPFN 243

  Fly   255 DPYIPCKEAGLAFQRGDVLHIVAQDDAYWWQARKEHERSARAGLIPSRALQERRILHDRTQKNGT 319
            |..||||||||.|.:|::|.||.::|..||||....| ...||||||:.|:|:|....|     .
Mouse   244 DNLIPCKEAGLKFSKGEILQIVNREDPNWWQASHVKE-GGSAGLIPSQFLEEKRKAFVR-----R 302

  Fly   320 DLDSKPGSCASLCTTPPGSPRLPASSSTSSCRQPKTKKIMYDLTENDDFDREQIATYEEVAKLYP 384
            |.|:....|.::                   ...|.||:||..|.|.:|||.:|..||||||:.|
Mouse   303 DWDNSGPFCGTI-------------------SNKKKKKMMYLTTRNAEFDRHEIQIYEEVAKMPP 348

  Fly   385 RPGVF--RPIVLIGAPGVGRNELRRRLIARDPEKFRSPVPYTTRPMRTGEVAGREYIFVAREKMD 447
                |  :.:|||||.||||..|:.|.|..:|.:|.:.||:|:|..|..|..|:.|.||:|.:|:
Mouse   349 ----FQRKTLVLIGAQGVGRRSLKNRFIVLNPARFGTTVPFTSRKPREDEKDGQAYKFVSRSEME 409

  Fly   448 ADIEAGKFVEHGEYKGHLYGTSAESVKSIVNAGCVCVLSPHYQAIKTLRTAQLKPFLIHVKPPEL 512
            |||:|||::|||||:|:||||..:|:..:|..|..|:|..:.||:|.|||::..|:::.:..|||
Mouse   410 ADIKAGKYLEHGEYEGNLYGTKIDSILEVVQTGRTCILDVNPQALKVLRTSEFMPYVVFIAAPEL 474

  Fly   513 DILKATRTEARAKSTFDEA-NARSFTDEEFEDMIKSAERIDFLYGHFFDVELVNGELVNAFEQLV 576
            :.|:|..     |:..|.. ..:..||.:.:..:..:.||...|.|:||:.:||..|..|||:|.
Mouse   475 ETLRAMH-----KAVVDAGITTKLLTDSDLKKTVDESARIQRAYNHYFDLIIVNDNLDKAFEKLQ 534

  Fly   577 QNVQRLENEPVWAPSMWV 594
            ..:::|..||.|.|..||
Mouse   535 TAIEKLRMEPQWVPISWV 552

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
metro	NP_610642.2	L27	17..68	CDD:197794	13/52 (25%)
		L27	75..127	CDD:197794	16/53 (30%)
		PDZ_signaling	139..229	CDD:238492	33/93 (35%)
		SH3_MPP	243..302	CDD:212796	32/58 (55%)
		Guanylate_kin	390..575	CDD:279019	75/185 (41%)
		GuKc	399..580	CDD:214504	71/181 (39%)
Pals2	NP_001158205.1	L27	2..55	CDD:197794	14/56 (25%)
		L27	57..108	CDD:397114	15/50 (30%)
		PDZ_signaling	132..205	CDD:238492	33/85 (39%)
		SH3_MPP6	232..292	CDD:212971	33/60 (55%)
		Guanylate_kin	350..540	CDD:395500	76/194 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848774
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740