DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment metro and dlg3

DIOPT Version :9

Sequence 1:	NP_610642.2	Gene:	metro / 36176	FlyBaseID:	FBgn0050021	Length:	595	Species:	Drosophila melanogaster
Sequence 2:	XP_021328515.1	Gene:	dlg3 / 564081	ZFINID:	ZDB-GENE-050208-93	Length:	940	Species:	Danio rerio

Alignment Length:	708	Identity:	175/708 - (24%)
Similarity:	279/708 - (39%)	Gaps:	230/708 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 LKALLESKELNALVN----VHTKVAKVGRDDRLAPVLSTSAQVLYEVLEQLSQHCHLND------ 92
            |:.:...:.:.||.|    |:.||||.|      ||                   ||||
Zfish   305 LQDVRHEEAVAALKNTSDMVYLKVAKPG------PV-------------------HLNDMYAPPD 344

  Fly    93 -----DCKEAFHLLQDSHL--------------------------------QHLLFAHDAIAQKD 120
                 ....||..:.|:|:                                :|:|...|....:.
Zfish   345 YSSSLGLPPAFPTMVDNHVGHNSSMAYMGGMEPKPVYQPPQVTPSRYSPVPRHMLGEEDFTRAEP 409

  Fly   121 FY--------------PHL-----------PEAPVEMDEDEETIKIVQLVKSNEPLTGAQSTEPI 160
            .|              |||           |..|.             |.:|..|.||.:..:.:
Zfish   410 IYSAIHKPHGDTSPPSPHLCSRGSGDVGCSPAPPA-------------LCQSLVPYTGREPRKIL 461

  Fly   161 -------VGATIKTDEESGKIIIARIMHGGAADRSGLIHVGDEVIEVNNINVEGKTPGDVLTILQ 218
                   :|..|...|:...|.::.|:.||.||.||.:..||.::.||.:|:...|.......|:
Zfish   462 LHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALK 526

  Fly   219 NSEGTITF--KLVP----------------------ADNKGAQRESKVR---VRAHFDYNPDVDP 256
            .:..|:|.  :..|                      :...|:.|.|:.|   |||.|||:...|.
Zfish   527 RAGQTVTIIAQYRPEEYSRFESKIHDLREQMMNSSMSSGSGSLRTSEKRSLYVRALFDYDRTRDS 591

  Fly   257 YIPCKEAGLAFQRGDVLHIVAQDDAYWWQAR--KEHERSARAGLIPSR-----------ALQERR 308
            .:|.:  ||:|..||:||::...|..|||||  ..|..|.:.|:|||:           ..:||.
Zfish   592 CLPSQ--GLSFSYGDILHVINASDDEWWQARLVTPHGESEQIGVIPSKKRYSTANRPGVEKKERA 654

  Fly   309 IL-----HDRT---QKN----GTDLDSKPGSCASLCTTPPGSPRLPASSSTSSCRQ-P--KTKK- 357
            .|     |.||   :.|    |...|.:|             .::....|.:..|: |  |:|:
Zfish   655 RLKTVKFHARTGMIESNREMFGRMNDIRP-------------VKVKRKKSFNLSRKFPFYKSKEN 706

  Fly   358 IMYDLTENDDF--------------DREQIATYEEVAKL---YPRPGVFRPIVLIGAPGVGRNEL 405
            |:.:|.|.:..              ..:.|.:||.|.:.   |.     ||::::|..   ::.:
Zfish   707 IVQELVETEQCLTSNTSDSESSSKGQEDTILSYEPVIRQEIHYT-----RPVIILGPM---KDRV 763

  Fly   406 RRRLIARDPEKFRSPVPYTTRPMRTGEVAGREYIFV-AREKMDADIEAGKFVEHGEYKGHLYGTS 469
            ...||:..|.||.|.||:||||.|..|:.|::|.|| :||:|:.||:..||:|.|::..:|||||
Zfish   764 NDDLISEFPHKFGSCVPHTTRPRRENEMDGQDYHFVGSREQMEKDIQDNKFIEAGQFNENLYGTS 828

  Fly   470 AESVKSIVNAGCVCVLSPHYQAIKTLRTAQLKPFLIHVKPPELDILKATRTEARAKSTFDEANAR 534
            ..||:::...|..|:|.....|||.|:.|||.|..|.:||..::.|    .|...:.|:::||
Zfish   829 ILSVRAVAERGKHCILDVSGNAIKRLQQAQLYPIAIFIKPKSVEAL----MELNKRQTYEQAN-- 887

  Fly   535 SFTDEEFEDMIKSAERIDFLYGHFFDVELVNGELVNAFEQLVQNVQRLENEP-VWAPS 591
                    .:...|.:::..:|.|| ..:|.|:.::.....::.:...::.| :|.||
Zfish   888 --------KVFDKAMKLEQEFGEFF-TAIVQGDSLDEIYNKIKLIIEEQSGPYIWIPS 936

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
metro	NP_610642.2	L27	17..68	CDD:197794	10/33 (30%)
		L27	75..127	CDD:197794	15/119 (13%)
		PDZ_signaling	139..229	CDD:238492	25/98 (26%)
		SH3_MPP	243..302	CDD:212796	27/63 (43%)
		Guanylate_kin	390..575	CDD:279019	62/185 (34%)
		GuKc	399..580	CDD:214504	59/181 (33%)
dlg3	XP_021328515.1	MAGUK_N_PEST	<109..149	CDD:313762
		PDZ_signaling	150..234	CDD:238492
		PDZ_signaling	243..329	CDD:238492	6/23 (26%)
		PDZ_assoc	330..409	CDD:313755	15/103 (15%)
		PDZ	456..540	CDD:214570	20/83 (24%)
		SH3_DLG3	575..639	CDD:212962	28/65 (43%)
		Guanylate_kin	749..927	CDD:279019	63/200 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810