Protein Alignment metro and Mpp2

DIOPT Version :9

• Sequence 1: NP_610642.2
• Gene: metro / 36176
• FlyBaseID: FBgn0050021
• Length: 595
• Species: Drosophila melanogaster
• Sequence 2: NP_001343253.1
• Gene: Mpp2 / 50997
• MGIID: 1858257
• Length: 569
• Species: Mus musculus
• Alignment Length: 592
• Identity: 206/592 - (34%)
• Similarity: 324/592 - (54%)
• Gaps: 63/592 - (10%)

  Fly    15 ALSKLISTLKESENLSNDQEID--FLKALLESKELNALVNVHTKVAKVGRDDRLAPVLSTSAQVL 77
            |:.:::..|....|.:...|:|  ||:.::||..:.:|...|.::    .:.:|..|...:.:::
Mouse    28 AMQQVLDNLGSLPNATGAAELDLIFLRGIMESPIVRSLAKAHERL----EETKLEAVRDNNLELV 88

  Fly    78 YEVLEQLSQHCHLNDDCKEAFHLLQDSHLQHLLFAHDAIAQKDFYPHLPEAPVEMDEDEETIKIV 142
            .|:|..|::....:....|...:||:.|.|.||..||::|.|.:     |.|......:.|.
Mouse    89 QEILRDLAELAEQSSTAAELARILQEPHFQSLLETHDSVASKTY-----ETPPPSPGLDPTF--- 145

  Fly   143 QLVKSNEP-------LTGAQSTE-PIVGATIKTDEESGKIIIARIMHGGAADRSGLIHVGDEVIE 199
                ||:|       :.|.:.|. ..:|.|.:.  |.|:::||||:|||...:.||:||||.:.|
Mouse   146 ----SNQPVPPDAVRMVGIRKTAGEHLGVTFRV--EGGELVIARILHGGMVAQQGLLHVGDIIKE 204

  Fly   200 VNNINVEGKTPGDVLTILQNSEGTITFKLVPADNKGAQRESKVRVRAHFDYNPDVDPYIPCKEAG 264
            ||...| |..|..:..:|:::.|::..|::|:..: .....:|.|:.||||:|..|...||||||
Mouse   205 VNGQPV-GSDPRALQELLRSASGSVILKILPSYQE-PHLPRQVFVKCHFDYDPARDSLSPCKEAG 267

  Fly   265 LAFQRGDVLHIVAQDDAYWWQARKEHERSARAGLIPSRALQERRILHDRTQKNGTDLDSKPGSCA 329
            |.|..||:|.||.||||.||||.  |.....||||||:.|:|:|....:     .||:..|.| .
Mouse   268 LRFNAGDLLQIVNQDDANWWQAC--HVEGGSAGLIPSQLLEEKRKAFVK-----RDLELTPTS-G 324

  Fly   330 SLCTTPPGSPRLPASSSTSSCRQPKTKKIMYDLTENDDFDREQIATYEEVAKLYPRPGVFR--PI 392
            :||.:..|.               |.|::||..|:|.:|||.::..|||||::.|    ||  .:
Mouse   325 TLCGSLSGK---------------KKKRMMYLTTKNAEFDRHELLIYEEVARMPP----FRRKTL 370

  Fly   393 VLIGAPGVGRNELRRRLIARDPEKFRSPVPYTTRPMRTGEVAGREYIFVAREKMDADIEAGKFVE 457
            |||||.||||..|:.:||..||:::.:.||||:|..:..|..|:.|.||:|.:|:|||.||:::|
Mouse   371 VLIGAQGVGRRSLKNKLILWDPDRYGTTVPYTSRRPKDSEREGQGYSFVSRGEMEADIRAGRYLE 435

  Fly   458 HGEYKGHLYGTSAESVKSIVNAGCVCVLSPHYQAIKTLRTAQLKPFLIHVKPPELDILKATRTEA 522
            ||||:|:||||..:|::.:|.:|.||||..:.||:|.||||:..|:::.::.|:.:.|:|....|
Mouse   436 HGEYEGNLYGTRIDSIRGVVASGKVCVLDVNPQAVKVLRTAEFVPYVVFIEAPDYETLRAMNRAA 500

  Fly   523 RAKSTFDEANARSFTDEEFEDMIKSAERIDFLYGHFFDVELVNGELVNAFEQLVQNVQRLENEPV 587
            ....    .:.:..|:.:....::.:.||...|||:||:.|||..|...|.:|...:::|..||.
Mouse   501 LESG----VSTKQLTEADLRRTVEESSRIQRGYGHYFDLSLVNSNLERTFRELQTAMEKLRTEPQ 561

  Fly   588 WAPSMWV 594
            |.|..||
Mouse   562 WVPVSWV 568

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
metro	NP_610642.2	L27	17..68	CDD:197794	11/52 (21%)
		L27	75..127	CDD:197794	14/51 (27%)
		PDZ_signaling	139..229	CDD:238492	31/97 (32%)
		SH3_MPP	243..302	CDD:212796	34/58 (59%)
		Guanylate_kin	390..575	CDD:279019	74/186 (40%)
		GuKc	399..580	CDD:214504	69/180 (38%)
Mpp2	NP_001343253.1	L27	30..83	CDD:197794	12/56 (21%)
		L27	85..136	CDD:308467	15/55 (27%)
		PDZ_signaling	155..233	CDD:238492	28/80 (35%)
		SH3_MPP2	246..304	CDD:212970	35/59 (59%)
		GuKc	376..557	CDD:214504	69/184 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848771
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740