Protein Alignment metro and CASK

DIOPT Version :10

• Sequence 1: NP_610642.2
• Gene: metro / 36176
• FlyBaseID: FBgn0050021
• Length: 595
• Species: Drosophila melanogaster
• Sequence 2: XP_061499758.1
• Gene: CASK / 4577273
• VectorBaseID: AGAMI1_013356
• Length: 955
• Species: Anopheles gambiae
• Alignment Length: 625
• Identity: 188/625 - (30%)
• Similarity: 313/625 - (50%)
• Gaps: 88/625 - (14%)

  Fly    15 ALSKLISTLKESENLSN-DQEIDFLKALLESKELNALVNVHTKVAKVGRDDRLAP---VLSTSAQ 75
            |:.|::.:|.:...|.: :.:.|.|..:|...:|:.|:.:..:::....:...||   .:|....
Mosquito   373 AIQKILDSLDDIIALQDANCDPDMLAGMLRDVKLHELLQLFDRISSSVINPSRAPPGDAISRCRD 437

  Fly    76 VLYEVLEQLSQHCHLNDDCKEAFHLLQDSHLQHLLFAHDAIAQKDF------------YPHLPEA 128
            .: :|:...:.|.::.:. .|..:||...|:|.||..||.:|::.:            .|:|...
Mosquito   438 AI-DVISSTAGHKYVREK-SELINLLGSPHIQALLHTHDVVAREVYGEEALRVTPPPIAPYLNGG 500

  Fly   129 PVEMDEDE-------ETIKIVQLVKSNEPLTGAQSTEPIVGATIKTDEESGKIIIARIMHGGAAD 186
            ..|:|..:       ..:::||..|:.:        || :|.|:|..|: |:.|:|||||||...
Mosquito   501 NDELDNGDAGELQHVTRVRLVQFQKNTD--------EP-MGITLKMTED-GRCIVARIMHGGMIH 555

  Fly   187 RSGLIHVGDEVIEVNNINVEGKTPGDVLTILQNSEGTITFKLVPADNKGAQRESKVR-------- 243
            |...:|||||:.|:|...|:.:|...:..:|:::.|::|||:||:...........|
Mosquito   556 RQATLHVGDEIREINGQPVQHQTVSQLQRLLRDARGSVTFKIVPSYRSAPPPVELFRIRPAPVLV 620

  Fly   244 ----VRAHFDYNPDVDPYIPCKEAGLAFQRGDVLHIVAQDDAYWWQARKEHERS-ARAGLIPSRA 303
                |||.|||:|..|..|||.:||:||:.||:|.|:::||.:|||||  |:.: ..||||||..
Mosquito   621 DQIFVRAQFDYDPLDDELIPCAQAGIAFRVGDILQIISKDDHHWWQAR--HDAAGGSAGLIPSPE 683

  Fly   304 LQERRILHDRTQKNGTDL-DSKPGSCASL--CTTPPGSPRLPASSSTSSC----RQPKTKKIMYD 361
            |||.||......|:..:. ::.||..|..  |..|          :..:|    |:.|..:..|.
Mosquito   684 LQEWRIACQSADKSHKEQGEAGPGCSAQAEGCEGP----------TVVNCSIFSRKKKQCRDKYL 738

  Fly   362 LTENDDFDREQIATYEEVAKLYPRPGVF--RPIVLIGAPGVGRNELRRRLIARDPEKFRSPVPYT 424
            ...|..||:..:.|||||.|:......|  |.:||:||.||||..::..|||:.|:|:..|:|:|
Mosquito   739 AKHNAVFDQLDLVTYEEVVKVPIGDPAFQRRTLVLLGAHGVGRRHIKNTLIAKYPDKYAYPIPHT 803

  Fly   425 TRPMRTGEVAGREYIFVAREKMDADIEAGKFVEHGEYKGHLYGTSAESVKSIVNAGCVCVLSPHY 489
            |||.|..|..||.|.|::.::|.|||.|.:::|:|.::..:|||..|:::.|...|.:.:|....
Mosquito   804 TRPPRPDEENGRSYYFISHDEMMADISANEYLEYGTHEDAMYGTKLETIRRIHADGKMAILDVEP 868

  Fly   490 QAIKTLRTAQLKPFLIHVKPPELDILKATRTEARAKSTFDEANARSFTDEEFEDMIKSAERIDFL 554
            ||:|.||||:..|:::.:..|.|.                  |...: |...|.:.|.::.:...
Mosquito   869 QALKILRTAEFTPYVVFIAAPLLQ------------------NIADY-DGSLERLAKESDMLRQA 914

  Fly   555 YGHFFDVELVNGELVNAFEQLVQNVQRLENEPVWAPSMWV 594
            ||||||:.:||.::......|...:.::.:...|.|..|:
Mosquito   915 YGHFFDLTIVNNDIGETIATLENAIDKVHSTAQWVPVSWL 954

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
metro	NP_610642.2	L27	17..68	CDD:197794	8/51 (16%)
		L27	75..127	CDD:197794	14/63 (22%)
		PDZ_MPP3-MPP4-MPP7-like	140..230	CDD:467260	33/89 (37%)
		SH3_MPP	243..302	CDD:212796	33/71 (46%)
		Guanylate_kin	390..575	CDD:395500	62/184 (34%)
CASK	XP_061499758.1	None