Protein Alignment metro and MPP2

DIOPT Version :9

• Sequence 1: NP_610642.2
• Gene: metro / 36176
• FlyBaseID: FBgn0050021
• Length: 595
• Species: Drosophila melanogaster
• Sequence 2: XP_011523129.2
• Gene: MPP2 / 4355
• HGNCID: 7220
• Length: 630
• Species: Homo sapiens
• Alignment Length: 620
• Identity: 211/620 - (34%)
• Similarity: 329/620 - (53%)
• Gaps: 87/620 - (14%)

  Fly    11 NWDPALSKLISTLKESENLSNDQEID--FLKALLESKELNALVNV-------------------- 53
            |.:.|:.:::..|....:.:...|:|  ||:.::||..:.:|..|
Human    61 NSETAMQQVLDNLGSLPSATGAAELDLIFLRGIMESPIVRSLAKVIMVLWFMQQNVFVPMKYMLK 125

  Fly    54 ----HTKVAKVGRDDRLAPVLSTSAQVLYEVLEQLSQHCHLNDDCKEAFHLLQDSHLQHLLFAHD 114
                |.::    .:.:|..|...:.:::.|:|..|:|....:....|..|:||:.|.|.||..||
Human   126 YFGAHERL----EETKLEAVRDNNLELVQEILRDLAQLAEQSSTAAELAHILQEPHFQSLLETHD 186

  Fly   115 AIAQKDFYPHLPEAPVEMDEDEETIKIVQLVKSNEP-------LTGAQSTE-PIVGATIKTDEES 171
            ::|.|.:     |.|......:.|.       ||:|       :.|.:.|. ..:|.|.:.  |.
Human   187 SVASKTY-----ETPPPSPGLDPTF-------SNQPVPPDAVRMVGIRKTAGEHLGVTFRV--EG 237

  Fly   172 GKIIIARIMHGGAADRSGLIHVGDEVIEVNNINVEGKTPGDVLTILQNSEGTITFKLVPADNKGA 236
            |:::||||:|||...:.||:||||.:.|||...| |..|..:..:|:|:.|::..|::|:..: .
Human   238 GELVIARILHGGMVAQQGLLHVGDIIKEVNGQPV-GSDPRALQELLRNASGSVILKILPSYQE-P 300

  Fly   237 QRESKVRVRAHFDYNPDVDPYIPCKEAGLAFQRGDVLHIVAQDDAYWWQARKEHERSARAGLIPS 301
            ....:|.|:.||||:|..|..||||||||.|..||:|.||.||||.||||.  |.....||||||
Human   301 HLPRQVFVKCHFDYDPARDSLIPCKEAGLRFNAGDLLQIVNQDDANWWQAC--HVEGGSAGLIPS 363

  Fly   302 RALQERRILHDRTQKNGTDLDSKPGSCASLCTTPPGSPRLPASSSTSSCRQPKTKKIMYDLTEND 366
            :.|:|:|....:     .||:..|.| .:||.:..|.               |.|::||..|:|.
Human   364 QLLEEKRKAFVK-----RDLELTPNS-GTLCGSLSGK---------------KKKRMMYLTTKNA 407

  Fly   367 DFDREQIATYEEVAKLYPRPGVFR--PIVLIGAPGVGRNELRRRLIARDPEKFRSPVPYTTRPMR 429
            :|||.::..|||||::.|    ||  .:|||||.||||..|:.:||..||:::.:.||||:|..:
Human   408 EFDRHELLIYEEVARMPP----FRRKTLVLIGAQGVGRRSLKNKLIMWDPDRYGTTVPYTSRRPK 468

  Fly   430 TGEVAGREYIFVAREKMDADIEAGKFVEHGEYKGHLYGTSAESVKSIVNAGCVCVLSPHYQAIKT 494
            ..|..|:.|.||:|.:|:||:.||:::|||||:|:||||..:|::.:|.||.||||..:.||:|.
Human   469 DSEREGQGYSFVSRGEMEADVRAGRYLEHGEYEGNLYGTRIDSIRGVVAAGKVCVLDVNPQAVKV 533

  Fly   495 LRTAQLKPFLIHVKPPELDILKATRTEARAKSTFDEANARSFTDEEFEDMIKSAERIDFLYGHFF 559
            ||||:..|:::.::.|:.:.|:|....|....    .:.:..|:.:....::.:.||...|||:|
Human   534 LRTAEFVPYVVFIEAPDFETLRAMNRAALESG----ISTKQLTEADLRRTVEESSRIQRGYGHYF 594

  Fly   560 DVELVNGELVNAFEQLVQNVQRLENEPVWAPSMWV 594
            |:.|||..|...|.:|...:::|..||.|.|..||
Human   595 DLCLVNSNLERTFRELQTAMEKLRTEPQWVPVSWV 629

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
metro	NP_610642.2	L27	17..68	CDD:197794	11/76 (14%)
		L27	75..127	CDD:197794	16/51 (31%)
		PDZ_signaling	139..229	CDD:238492	32/97 (33%)
		SH3_MPP	243..302	CDD:212796	35/58 (60%)
		Guanylate_kin	390..575	CDD:279019	74/186 (40%)
		GuKc	399..580	CDD:214504	69/180 (38%)
MPP2	XP_011523129.2	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158376
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740