Protein Alignment metro and MPP1

DIOPT Version :10

• Sequence 1: NP_610642.2
• Gene: metro / 36176
• FlyBaseID: FBgn0050021
• Length: 595
• Species: Drosophila melanogaster
• Sequence 2: NP_002427.1
• Gene: MPP1 / 4354
• HGNCID: 7219
• Length: 466
• Species: Homo sapiens
• Alignment Length: 513
• Identity: 168/513 - (32%)
• Similarity: 267/513 - (52%)
• Gaps: 84/513 - (16%)

  Fly   101 LQDSHLQHLLFAH---DAIAQ------KDFYPH---LPEAPVEMDEDE-ETIKIVQLVKSNEPLT 152
            |.|.:|:|||...   :|::.      :|.|.:   .|.:|.::...| ..::::|..|..|
Human    18 LSDLYLEHLLQKRSRPEAVSHPLNTVTEDMYTNGSPAPGSPAQVKGQEVRKVRLIQFEKVTE--- 79

  Fly   153 GAQSTEPIVGATIKTDEESGKIIIARIMHGGAADRSGLIHVGDEVIEVNNINVEGKTPGDVLTIL 217
                 || :|.|:|.:|:. ...:|||:|||...|.|.:|||||::|:|..||...:...:...:
Human    80 -----EP-MGITLKLNEKQ-SCTVARILHGGMIHRQGSLHVGDEILEINGTNVTNHSVDQLQKAM 137

  Fly   218 QNSEGTITFKLVPADNKGAQRES-KVRVRAHFDYNPDVDPYIPCKEAGLAFQRGDVLHIVAQDDA 281
            :.::|.|:.|::|  |:.::..: ::.:||.|||:|..|..||||||||.|..||::.|:.:||:
Human   138 KETKGMISLKVIP--NQQSRLPALQMFMRAQFDYDPKKDNLIPCKEAGLKFATGDIIQIINKDDS 200

  Fly   282 YWWQARKEHERSARAGLIPSRALQERRILHDRTQKNGTDLDSKPGSCASLCTTPPGSPRLPASSS 346
            .|||.|.|......||||||..|||.|:                   ||:..:.|        |.
Human   201 NWWQGRVEGSSKESAGLIPSPELQEWRV-------------------ASMAQSAP--------SE 238

  Fly   347 TSSCR---QPKTKKIMYDLTENDDFDREQIATYEEVAKL--YPRPGVFRPIVLIGAPGVGRNELR 406
            ..||.   :.|..|..|....:..||:..:.:||||.:|  :.|    :.:|||||.||||:.::
Human   239 APSCSPFGKKKKYKDKYLAKHSSIFDQLDVVSYEEVVRLPAFKR----KTLVLIGASGVGRSHIK 299

  Fly   407 RRLIARDPEKFRSPVPYTTRPMRTGEVAGREYIFVAREKMDADIEAGKFVEHGEYKGHLYGTSAE 471
            ..|::::||||..||||||||.|..|..|:||.|::.|:|..:|.|.:|:|.|.|:|:::||..|
Human   300 NALLSQNPEKFVYPVPYTTRPPRKSEEDGKEYHFISTEEMTRNISANEFLEFGSYQGNMFGTKFE 364

  Fly   472 SVKSIVNAGCVCVLSPHYQAIKTLRTAQLKPFLIHVKPPELDILKATRTEARAKSTFDEANARSF 536
            :|..|.....:.:|....|.:|.:|||:|.||::.:.|.:    :.|:|||
Human   365 TVHQIHKQNKIAILDIEPQTLKIVRTAELSPFIVFIAPTD----QGTQTEA-------------- 411

  Fly   537 TDEEFEDMIKSAERIDFLYGHFFDVELVNGELVNAFEQLVQNVQRLENEPVWAPSMWV 594
                .:.:.|.:|.|...|.|:||:.|||..:....::|.:...:..:.|.|.|..||
Human   412 ----LQQLQKDSEAIRSQYAHYFDLSLVNNGVDETLKKLQEAFDQACSSPQWVPVSWV 465

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
metro	NP_610642.2	L27	17..68	CDD:197794
		L27	75..127	CDD:197794	9/37 (24%)
		PDZ_MPP3-MPP4-MPP7-like	140..230	CDD:467260	29/89 (33%)
		SH3_MPP	243..302	CDD:212796	31/58 (53%)
		Guanylate_kin	390..575	CDD:395500	66/184 (36%)
MPP1	NP_002427.1	PDZ_MPP1-like	70..150	CDD:467266	29/89 (33%)
		SH3_MPP1	162..223	CDD:213013	32/60 (53%)
		Interaction with PALS1. /evidence=ECO:0000269|PubMed:17584769	268..466		78/224 (35%)
		Guanylate_kin	281..453	CDD:395500	68/197 (35%)