DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment metro and MPP1

DIOPT Version :9

Sequence 1:	NP_610642.2	Gene:	metro / 36176	FlyBaseID:	FBgn0050021	Length:	595	Species:	Drosophila melanogaster
Sequence 2:	NP_002427.1	Gene:	MPP1 / 4354	HGNCID:	7219	Length:	466	Species:	Homo sapiens

Alignment Length:	513	Identity:	168/513 - (32%)
Similarity:	267/513 - (52%)	Gaps:	84/513 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   101 LQDSHLQHLLFAH---DAIAQ------KDFYPH---LPEAPVEMDEDE-ETIKIVQLVKSNEPLT 152
            |.|.:|:|||...   :|::.      :|.|.:   .|.:|.::...| ..::::|..|..|
Human    18 LSDLYLEHLLQKRSRPEAVSHPLNTVTEDMYTNGSPAPGSPAQVKGQEVRKVRLIQFEKVTE--- 79

  Fly   153 GAQSTEPIVGATIKTDEESGKIIIARIMHGGAADRSGLIHVGDEVIEVNNINVEGKTPGDVLTIL 217
                 || :|.|:|.:|:. ...:|||:|||...|.|.:|||||::|:|..||...:...:...:
Human    80 -----EP-MGITLKLNEKQ-SCTVARILHGGMIHRQGSLHVGDEILEINGTNVTNHSVDQLQKAM 137

  Fly   218 QNSEGTITFKLVPADNKGAQRES-KVRVRAHFDYNPDVDPYIPCKEAGLAFQRGDVLHIVAQDDA 281
            :.::|.|:.|::|  |:.::..: ::.:||.|||:|..|..||||||||.|..||::.|:.:||:
Human   138 KETKGMISLKVIP--NQQSRLPALQMFMRAQFDYDPKKDNLIPCKEAGLKFATGDIIQIINKDDS 200

  Fly   282 YWWQARKEHERSARAGLIPSRALQERRILHDRTQKNGTDLDSKPGSCASLCTTPPGSPRLPASSS 346
            .|||.|.|......||||||..|||.|:                   ||:..:.|        |.
Human   201 NWWQGRVEGSSKESAGLIPSPELQEWRV-------------------ASMAQSAP--------SE 238

  Fly   347 TSSCR---QPKTKKIMYDLTENDDFDREQIATYEEVAKL--YPRPGVFRPIVLIGAPGVGRNELR 406
            ..||.   :.|..|..|....:..||:..:.:||||.:|  :.|    :.:|||||.||||:.::
Human   239 APSCSPFGKKKKYKDKYLAKHSSIFDQLDVVSYEEVVRLPAFKR----KTLVLIGASGVGRSHIK 299

  Fly   407 RRLIARDPEKFRSPVPYTTRPMRTGEVAGREYIFVAREKMDADIEAGKFVEHGEYKGHLYGTSAE 471
            ..|::::||||..||||||||.|..|..|:||.|::.|:|..:|.|.:|:|.|.|:|:::||..|
Human   300 NALLSQNPEKFVYPVPYTTRPPRKSEEDGKEYHFISTEEMTRNISANEFLEFGSYQGNMFGTKFE 364

  Fly   472 SVKSIVNAGCVCVLSPHYQAIKTLRTAQLKPFLIHVKPPELDILKATRTEARAKSTFDEANARSF 536
            :|..|.....:.:|....|.:|.:|||:|.||::.:.|.:    :.|:|||
Human   365 TVHQIHKQNKIAILDIEPQTLKIVRTAELSPFIVFIAPTD----QGTQTEA-------------- 411

  Fly   537 TDEEFEDMIKSAERIDFLYGHFFDVELVNGELVNAFEQLVQNVQRLENEPVWAPSMWV 594
                .:.:.|.:|.|...|.|:||:.|||..:....::|.:...:..:.|.|.|..||
Human   412 ----LQQLQKDSEAIRSQYAHYFDLSLVNNGVDETLKKLQEAFDQACSSPQWVPVSWV 465

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
metro	NP_610642.2	L27	17..68	CDD:197794
		L27	75..127	CDD:197794	9/37 (24%)
		PDZ_signaling	139..229	CDD:238492	29/89 (33%)
		SH3_MPP	243..302	CDD:212796	31/58 (53%)
		Guanylate_kin	390..575	CDD:279019	66/184 (36%)
		GuKc	399..580	CDD:214504	62/180 (34%)
MPP1	NP_002427.1	PDZ	71..149	CDD:366185	29/87 (33%)
		SH3_MPP1	162..223	CDD:213013	32/60 (53%)
		Interaction with PALS1. /evidence=ECO:0000269\|PubMed:17584769	268..466		78/224 (35%)
		Guanylate_kin	281..453	CDD:366206	68/197 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158380
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740