DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment metro and CASK

DIOPT Version :9

Sequence 1:	NP_610642.2	Gene:	metro / 36176	FlyBaseID:	FBgn0050021	Length:	595	Species:	Drosophila melanogaster
Sequence 2:	NP_001262811.1	Gene:	CASK / 42567	FlyBaseID:	FBgn0013759	Length:	929	Species:	Drosophila melanogaster

Alignment Length:	625	Identity:	195/625 - (31%)
Similarity:	309/625 - (49%)	Gaps:	118/625 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 ALSKLISTLKESENLSNDQ-EIDFLKALLESKELNALVNVHTKVAKVGRDDRLAPVLSTS----- 73
            |:.:::..|.:..:|.:.. :.|.|:.:|....|:..:.:.         ||:|..:.||
  Fly   346 AVQRILDCLDDIYSLQDAHVDADVLRDMLRDNRLHQFLQLF---------DRIAATVVTSNGRAP 401

  Fly    74 -AQVL---YEVLEQLSQHCHLND-----DCKEAFHLLQDSHLQHLLFAHDAIAQKDFY------- 122
             |:.:   .:||||||.....|.     ..:|...||...|:|.||.:||.:| :|.|
  Fly   402 AAEAVGRCRDVLEQLSSTSGGNSLGGKYAKEELMRLLAAPHMQALLHSHDVVA-RDVYGEEALRV 465

  Fly   123 --PHLPEAPV----EMDEDE-------ETIKIVQLVKSNEPLTGAQSTEPIVGATIKTDEESGKI 174
              |  |..|.    |:|..|       ..:::||..|:.:        || :|.|:|..|: |:.
  Fly   466 TPP--PMVPYLNGDELDNVEGGELQHVTRVRLVQFQKNTD--------EP-MGITLKMTED-GRC 518

  Fly   175 IIARIMHGGAADRSGLIHVGDEVIEVNNINVEGKTPGDVLTILQNSEGTITFKLVPADNKGAQRE 239
            |:|||||||...|...:|||||:.|:|...|:.::.|.:..:|:.:.|::|||:||: .:.|...
  Fly   519 IVARIMHGGMIHRQATLHVGDEIREINGQPVQHQSVGQLQRMLREARGSVTFKIVPS-YRSAPPP 582

  Fly   240 SKVRVRAHFDYNPDVDPYIPCKEAGLAFQRGDVLHIVAQDDAYWWQARKEHERSARAGLIPSRAL 304
            .::.|||.|||||..|..|||.:||::||.||:|.|:::||.:|||||.: .....||||||..|
  Fly   583 CEIFVRAQFDYNPLDDELIPCAQAGISFQVGDILQIISKDDHHWWQARLD-TVGGSAGLIPSPEL 646

  Fly   305 QERRILHDRTQKNGTDLDSKPGSCASLCTTPPGSPRLPASSSTSSC----RQPKTKKIMYDLTEN 365
            ||.||                 :|.::..|         .....:|    |:.|..:..|....|
  Fly   647 QEWRI-----------------ACQTVDKT---------KQEQVNCSIFGRKKKQCRDKYLAKHN 685

  Fly   366 DDFDREQIATYEEVAKL------YPRPGVFRPIVLIGAPGVGRNELRRRLIARDPEKFRSPVPYT 424
            ..||...:.|||||.|:      :.|    :.:||:||.||||..::..||::.|:|:..|:|:|
  Fly   686 AIFDTLDVVTYEEVVKVPVGDPNFQR----KTLVLLGAHGVGRRHIKNTLISKYPDKYAYPIPHT 746

  Fly   425 TRPMRTGEVAGREYIFVAREKMDADIEAGKFVEHGEYKGHLYGTSAESVKSIVNAGCVCVLSPHY 489
            |||.:..|..||.|.||:.::|.|||.|.:::|:|.::..:|||..::::.|...|.:.:|....
  Fly   747 TRPAKPEEENGRSYYFVSHDEMMADIGANEYLEYGTHEDAMYGTKLDTIRRIHTEGKMAILDVEP 811

  Fly   490 QAIKTLRTAQLKPFLIHVKPPELDILKATRTEARAKSTFDEANARSFTDEEFEDMIKSAERIDFL 554
            ||:|.||||:..|:::.:..|.|.                  |...: |...|.:.|.:|.:..|
  Fly   812 QALKILRTAEFTPYVVFIAAPSLQ------------------NIADY-DGSLERLAKESEMLRQL 857

  Fly   555 YGHFFDVELVNGELVNAFEQLVQNVQRLENEPVWAPSMWV 594
            ||||||:.:||.::......|...:.|:...|.|.|..|:
  Fly   858 YGHFFDLTIVNNDISETIATLETAIDRVHTTPQWVPVSWL 897

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
metro	NP_610642.2	L27	17..68	CDD:197794	8/51 (16%)
		L27	75..127	CDD:197794	20/68 (29%)
		PDZ_signaling	139..229	CDD:238492	33/89 (37%)
		SH3_MPP	243..302	CDD:212796	32/58 (55%)
		Guanylate_kin	390..575	CDD:279019	61/184 (33%)
		GuKc	399..580	CDD:214504	58/180 (32%)
CASK	NP_001262811.1	STKc_CASK	8..308	CDD:270996
		S_TKc	12..278	CDD:214567
		L27	347..396	CDD:280918	9/57 (16%)
		L27	406..462	CDD:280918	19/56 (34%)
		PDZ_signaling	493..573	CDD:238492	33/89 (37%)
		SH3_CASK	586..646	CDD:213014	33/60 (55%)
		Guanylate_kin	710..883	CDD:279019	63/195 (32%)
		GuKc	720..883	CDD:214504	58/181 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468173
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23122
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840