DRSC/TRiP Functional Genomics Resources

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Protein Alignment metro and dlg4b

DIOPT Version :9

Sequence 1:NP_610642.2 Gene:metro / 36176 FlyBaseID:FBgn0050021 Length:595 Species:Drosophila melanogaster
Sequence 2:NP_999893.1 Gene:dlg4b / 405796 ZFINID:ZDB-GENE-040628-3 Length:801 Species:Danio rerio


Alignment Length:595 Identity:151/595 - (25%)
Similarity:256/595 - (43%) Gaps:151/595 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    49 ALVNVHTKVAKVGRDDRLAPVLSTSAQVLYEVLEQLSQHCHLNDDCKEAFHL--LQDSHLQHLLF 111
            |:.|::  :.:|..:|.:|.:.:|...|...|.:.|.||.|     ::|::.  :..|:..|:  
Zfish   302 AVNNMY--LEEVMHEDAVAALKNTGDVVFLRV
AKTLHQHHH-----QDAYNPPDITSSYSPHM-- 357

  Fly   112 AHDAIAQKDFYPHL--PEAP---------VEMDED--EETIKIVQLVKSNEPLTGAQSTEPIVGA 163
                  ....||..  |.:|         :.:|:|  .|..::|    .:...||       :|.
Zfish   358 ------DMSDYPQALSPSSPRRYSPIPKGLFLDDDISREPRRVV----IHRGSTG-------LGF 405

  Fly   164 TIKTDEESGKIIIARIMHGGAADRSGLIHVGDEVIEVNNINVEGKTPGDVLTILQNSEGTITFKL 228
            .|...|:...|.|:.|:.|||||.||.:..||:::.||.:::...|.......|:|:..|:|...
Zfish   406 NIVGGEDGEGIFISFILAGGAADLSGELRKGDQILSVNGVDLRHATHEQAAAALKNAGQTVTIIT 470

  Fly   229 VPADNKGAQRESKVR--------------------------VRAHFDYNPDVDPYIPCKEAGLAF 267
            .....:.::.|:|:.                          :||.|||:...|...  ....::|
Zfish   471 Q
YRPEEYSRFEAKIHDLREQLMNSSLVSAAASLRSGKRSFFIRALFDYDKTADGGF--LSQAVSF 533

  Fly   268 QRGDVLHIVAQDDAYWWQARK--EHERSARAGLIPSRALQERRILHDRTQKNGTDLDSKPGSCAS 330
            :.||||.:....|..||||.|  .|......|.|||:...||: ...|.:..|            
Zfish   534 RFGDVLQVFDCSDEEWWQAGKLAPHGELEETGYIPSKRRVERK-EWSRLKTRG------------ 585

  Fly   331 LCTTPPGSPRLPASSSTSSCRQPKTKKIMYDLTENDDFDREQIATYEEVAKLYPRPGVFRPIVLI 395
                                |:|.:.:..|            |.:||.|.:  ......||::::
Zfish   586 --------------------REPVSGRSDY------------IVSYETVTQ--SEVHYARPVIIL 616

  Fly   396 GAPGVGRNELRRRLIARDPEKFRSPVPYTTRPMRTGEVAGREYIFV-AREKMDADIEAGKFVEHG 459
            |.   .::.:...|::..|:||.|.||:||||.|..|:.||:|.|| :||:|:.||::.:|:|.|
Zfish   617 GP---SKDRVNDDLLSEFPDKFGSCVPHTTRPKREYEMDGRDYHFVSSREQMEKDIQSHRFIEAG 678

  Fly   460 EYKGHLYGTSAESVKSIV-NAGCVCVLSPHYQAIKTLRTAQLKPFLIHVKPPEL-DILKATR--T 520
            :|..||||||.:||:.:. ..|..|:|.....|::.|:.|||.|..|.::|..| ::|..::  |
Zfish   679 QYNSHLYGTSVQSVRQVAEQQGKHCILDVSANAVRRLQAAQLYPIAIFIRPSSLQNVLNISKRLT 743

  Fly   521 EARAKSTFDEANARSFTDEEFEDMIKSAERIDFLYGHFFDVELVNGELVNAFEQLVQNVQRLENE 585
            |.:|:...|.|             :|..:  ||:  ..|.. :|.||   :||::..:|:.:..|
Zfish   744 EEQARRALDRA-------------VKLEQ--DFI--ECFSA-IVEGE---SFEEIYHHVKSVIEE 787

  Fly   586 P----VWAPS 591
            .    :|.|:
Zfish   788 QSGPYIWIPA 797

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
metroNP_610642.2 L27 17..68 CDD:197794 4/18 (22%)
L27 75..127 CDD:197794 11/55 (20%)
PDZ_signaling 139..229 CDD:238492 25/89 (28%)
SH3_MPP 243..302 CDD:212796 21/86 (24%)
Guanylate_kin 390..575 CDD:279019 65/189 (34%)
GuKc 399..580 CDD:214504 62/185 (34%)
dlg4bNP_999893.1 L27_1 4..58 CDD:286187
MAGUK_N_PEST 71..152 CDD:287565
PDZ 153..237 CDD:278991
PDZ 245..331 CDD:214570 7/30 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 339..373 8/46 (17%)
PDZ_assoc 342..392 CDD:287558 10/57 (18%)
PDZ_signaling 391..471 CDD:238492 25/90 (28%)
SH3 509..574 CDD:302595 22/66 (33%)
Guanylate_kin 609..788 CDD:279019 66/202 (33%)
GuKc 617..788 CDD:214504 64/194 (33%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

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