Protein Alignment metro and pals2a

DIOPT Version :9

• Sequence 1: NP_610642.2
• Gene: metro / 36176
• FlyBaseID: FBgn0050021
• Length: 595
• Species: Drosophila melanogaster
• Sequence 2: NP_001243118.1
• Gene: pals2a / 402878
• ZFINID: ZDB-GENE-050506-35
• Length: 550
• Species: Danio rerio
• Alignment Length: 596
• Identity: 208/596 - (34%)
• Similarity: 331/596 - (55%)
• Gaps: 73/596 - (12%)

  Fly    15 ALSKLISTLKESENLSNDQEID--FLKALLESKELNALVNVHTKVAKVGRDDRLAPVLSTSAQVL 77
            |:.:::..|||....:..::||  ||:.::||..:.:|...|.::    .|.:|..|.|.:.:::
Zfish    11 AMQQVLDNLKELPPSTGAKDIDLIFLRGIMESPIVRSLAKAHERL----EDVKLEAVQSNNVELV 71

  Fly    78 YEVLEQLSQHCHLNDDCKEAFHLLQDSHLQHLLFAHDAIAQKDFYPHLPEAP------VEMDEDE 136
            .|:|..:|.....::...|..::|::.|.|.||.|||.:|.|.:     |||      ..|....
Zfish    72 SEILSDMSSLIIRDESAAELSNILKEPHFQSLLEAHDKVASKSY-----EAPPTSTNSTSMSSSS 131

  Fly   137 ----ETIKIVQL-VKSNEPLTGAQSTEPIVGATIKTDEESGKIIIARIMHGGAADRSGLIHVGDE 196
                :|::::.: .|:.|||          |.|.:.:|  |.::|||::||...||.|::|.||.
Zfish   132 LMPADTVRMISIQKKAGEPL----------GVTFRVEE--GDLVIARVLHGSMIDRQGMLHAGDV 184

  Fly   197 VIEVNNINVEGKTPGDVLTILQNSEGTITFKLVPADNKGAQRESKVRVRAHFDYNPDVDPYIPCK 261
            :.|||...| ||.|..:..:|::..|:||.|::|: .|.....::|.::.||:|||:.|..|||:
Zfish   185 IREVNGREV-GKDPMALQHMLRDCNGSITLKILPS-YKDTPPPAQVYLKPHFNYNPNTDNLIPCR 247

  Fly   262 EAGLAFQRGDVLHIVAQDDAYWWQARKEHERSARAGLIPSRALQERRILHDRTQKNGTDLDSKPG 326
            ||||||.:||:||||.::|..||||.  :......|||||:.|:|:|....|...:|:.:
Zfish   248 EAGLAFSKGDILHIVNKEDPNWWQAC--NINGGHTGLIPSQFLEEKRKAFVRRDLDGSGI----- 305

  Fly   327 SCASLCTTPPGSPRLPASSSTSSCRQPKTKKIMYDLTENDDFDREQIATYEEVAKLYPRPGVF-- 389
                ||.|..|              :.|.||:||...:|.:|||.::..||||||:.|    |
Zfish   306 ----LCGTLTG--------------KKKKKKMMYLTAKNAEFDRHELQIYEEVAKMPP----FQR 348

  Fly   390 RPIVLIGAPGVGRNELRRRLIARDPEKFRSPVPYTTRPMRTGEVAGREYIFVAREKMDADIEAGK 454
            :.:|||||.||||..|:.|||..:|.::.:.||:|:|..|..|..|:.|.||:||:|:.||:|.:
Zfish   349 KTLVLIGAQGVGRRSLKNRLIVLNPLRYGTTVPFTSRRPRDDEKDGQSYCFVSREEMEMDIKASR 413

  Fly   455 FVEHGEYKGHLYGTSAESVKSIVNAGCVCVLSPHYQAIKTLRTAQLKPFLIHVKPPELDILKATR 519
            ::|||||.|:||||..:|:..:|.||..|:|..:.||:|.|:|::..||::.:..||||.|:|..
Zfish   414 YLEHGEYDGNLYGTKMDSIHEVVRAGRTCILDVNPQALKVLKTSEFMPFVVFIAAPELDTLRAMH 478

  Fly   520 TEARAKSTFDEA-NARSFTDEEFEDMIKSAERIDFLYGHFFDVELVNGELVNAFEQLVQNVQRLE 583
                 |:..|.. ..:..|:.:.:..:..:.||...|.|:||:.:||..|..|||:|...|::|.
Zfish   479 -----KAVVDAGITTKLLTETDLKKTVDESARIKRAYNHYFDLTIVNDNLDKAFEKLQAAVEQLT 538

  Fly   584 NEPVWAPSMWV 594
            .:|.|.|..||
Zfish   539 TQPQWVPVNWV 549

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
metro	NP_610642.2	L27	17..68	CDD:197794	13/52 (25%)
		L27	75..127	CDD:197794	14/51 (27%)
		PDZ_signaling	139..229	CDD:238492	31/90 (34%)
		SH3_MPP	243..302	CDD:212796	30/58 (52%)
		Guanylate_kin	390..575	CDD:279019	74/185 (40%)
		GuKc	399..580	CDD:214504	70/181 (39%)
pals2a	NP_001243118.1	L27	13..66	CDD:197794	14/56 (25%)
		L27	68..119	CDD:308467	16/55 (29%)
		PDZ_signaling	138..216	CDD:238492	31/90 (34%)
		SH3_MPP	229..286	CDD:212796	30/58 (52%)
		Guanylate_kin	347..537	CDD:331880	76/194 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594308
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.740