Protein Alignment metro and pals2a

DIOPT Version :10

• Sequence 1: NP_610642.2
• Gene: metro / 36176
• FlyBaseID: FBgn0050021
• Length: 595
• Species: Drosophila melanogaster
• Sequence 2: XP_073780864.1
• Gene: pals2a / 402878
• ZFINID: ZDB-GENE-050506-35
• Length: 683
• Species: Danio rerio
• Alignment Length: 609
• Identity: 210/609 - (34%)
• Similarity: 336/609 - (55%)
• Gaps: 73/609 - (11%)

  Fly     2 LEAVMASDINWDPALSKLISTLKESENLSNDQEID--FLKALLESKELNALVNVHTKVAKVGRDD 64
            :|.:..|:.....|:.:::..|||....:..::||  ||:.::||..:.:|...|.::    .|.
Zfish   131 IETMTVSNAKSGTAMQQVLDNLKELPPSTGAKDIDLIFLRGIMESPIVRSLAKAHERL----EDV 191

  Fly    65 RLAPVLSTSAQVLYEVLEQLSQHCHLNDDCKEAFHLLQDSHLQHLLFAHDAIAQKDFYPHLPEAP 129
            :|..|.|.:.:::.|:|..:|.....::...|..::|::.|.|.||.|||.:|.|.:     |||
Zfish   192 KLEAVQSNNVELVSEILSDMSSLIIRDESAAELSNILKEPHFQSLLEAHDKVASKSY-----EAP 251

  Fly   130 ------VEMDEDE----ETIKIVQL-VKSNEPLTGAQSTEPIVGATIKTDEESGKIIIARIMHGG 183
                  ..|....    :|::::.: .|:.|||          |.|.:.:|  |.::|||::||.
Zfish   252 PTSTNSTSMSSSSLMPADTVRMISIQKKAGEPL----------GVTFRVEE--GDLVIARVLHGS 304

  Fly   184 AADRSGLIHVGDEVIEVNNINVEGKTPGDVLTILQNSEGTITFKLVPADNKGAQRESKVRVRAHF 248
            ..||.|::|.||.:.|||...| ||.|..:..:|::..|:||.|::|: .|.....::|.::.||
Zfish   305 MIDRQGMLHAGDVIREVNGREV-GKDPMALQHMLRDCNGSITLKILPS-YKDTPPPAQVYLKPHF 367

  Fly   249 DYNPDVDPYIPCKEAGLAFQRGDVLHIVAQDDAYWWQARKEHERSARAGLIPSRALQERRILHDR 313
            :|||:.|..|||:||||||.:||:||||.::|..||||.  :......|||||:.|:|:|....|
Zfish   368 NYNPNTDNLIPCREAGLAFSKGDILHIVNKEDPNWWQAC--NINGGHTGLIPSQFLEEKRKAFVR 430

  Fly   314 TQKNGTDLDSKPGSCASLCTTPPGSPRLPASSSTSSCRQPKTKKIMYDLTENDDFDREQIATYEE 378
            ...:|:.:         ||.|..|              :.|.||:||...:|.:|||.::..|||
Zfish   431 RDLDGSGI---------LCGTLTG--------------KKKKKKMMYLTAKNAEFDRHELQIYEE 472

  Fly   379 VAKLYPRPGVF--RPIVLIGAPGVGRNELRRRLIARDPEKFRSPVPYTTRPMRTGEVAGREYIFV 441
            |||:.|    |  :.:|||||.||||..|:.|||..:|.::.:.||:|:|..|..|..|:.|.||
Zfish   473 VAKMPP----FQRKTLVLIGAQGVGRRSLKNRLIVLNPLRYGTTVPFTSRRPRDDEKDGQSYCFV 533

  Fly   442 AREKMDADIEAGKFVEHGEYKGHLYGTSAESVKSIVNAGCVCVLSPHYQAIKTLRTAQLKPFLIH 506
            :||:|:.||:|.:::|||||.|:||||..:|:..:|.||..|:|..:.||:|.|:|::..||::.
Zfish   534 SREEMEMDIKASRYLEHGEYDGNLYGTKMDSIHEVVRAGRTCILDVNPQALKVLKTSEFMPFVVF 598

  Fly   507 VKPPELDILKATRTEARAKSTFDEA-NARSFTDEEFEDMIKSAERIDFLYGHFFDVELVNGELVN 570
            :..||||.|:|..     |:..|.. ..:..|:.:.:..:..:.||...|.|:||:.:||..|..
Zfish   599 IAAPELDTLRAMH-----KAVVDAGITTKLLTETDLKKTVDESARIKRAYNHYFDLTIVNDNLDK 658

  Fly   571 AFEQLVQNVQRLENEPVWAPSMWV 594
            |||:|...|::|..:|.|.|..||
Zfish   659 AFEKLQAAVEQLTTQPQWVPVNWV 682

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
metro	NP_610642.2	L27	17..68	CDD:197794	13/52 (25%)
		L27	75..127	CDD:197794	14/51 (27%)
		PDZ_MPP3-MPP4-MPP7-like	140..230	CDD:467260	31/90 (34%)
		SH3_MPP	243..302	CDD:212796	30/58 (52%)
		Guanylate_kin	390..575	CDD:395500	74/185 (40%)
pals2a	XP_073780864.1	None