Protein Alignment metro and pals2b

DIOPT Version :10

• Sequence 1: NP_610642.2
• Gene: metro / 36176
• FlyBaseID: FBgn0050021
• Length: 595
• Species: Drosophila melanogaster
• Sequence 2: XP_005170070.1
• Gene: pals2b / 394134
• ZFINID: ZDB-GENE-040426-775
• Length: 580
• Species: Danio rerio
• Alignment Length: 609
• Identity: 214/609 - (35%)
• Similarity: 325/609 - (53%)
• Gaps: 73/609 - (11%)

  Fly     3 EAVMASDINWDP--ALSKLISTLKESENLSNDQEID--FLKALLESKELNALVNVHTKVAKVGRD 63
            |.|...|...||  |:.:::..|.|..:.:..::||  |||.::||..:.:|...|.::    .|
Zfish    27 EGVSELDEGADPSGAMQQVLDNLGELPSTTGAKDIDLIFLKGIMESPIVRSLAKAHERL----ED 87

  Fly    64 DRLAPVLSTSAQVLYEVLEQLSQHCHLNDDCKEAFHLLQDSHLQHLLFAHDAIAQKDFYPHLPEA 128
            .:|..|...:.:::.::|..:|.....:|...|...:||:.|.|.||.|||.:|.|.:  ..| |
Zfish    88 VKLEAVQENNVELVTDILGDISGLSVRDDSAAELSKILQEPHFQSLLEAHDMVASKCY--EAP-A 149

  Fly   129 PVEMDED---------EETIKIVQL-VKSNEPLTGAQSTEPIVGATIKTDEESGKIIIARIMHGG 183
            |.|:..|         .:.::::.: .|:.|||          |.|.:.|:  |.::||||:|||
Zfish   150 PPELTNDAAVNNALMQADAVRMIGIRKKAGEPL----------GVTFRMDK--GDLVIARILHGG 202

  Fly   184 AADRSGLIHVGDEVIEVNNINVEGKTPGDVLTILQNSEGTITFKLVPADNKGAQRESKVRVRAHF 248
            ..||.||:||||.:.|||..:| |..|.::..:|:...|.||.|::|: .:.|....:|.|:.||
Zfish   203 LIDRQGLLHVGDIIKEVNGKDV-GTNPTELQEMLKECSGGITLKILPS-YRDAPAPPQVYVKPHF 265

  Fly   249 DYNPDVDPYIPCKEAGLAFQRGDVLHIVAQDDAYWWQARKEHERSARAGLIPSRALQERRILHDR 313
            ||||..|..|||:||||||:|||:|.||.::|..||||.  |......|||||:.|:|:|.....
Zfish   266 DYNPASDNLIPCREAGLAFKRGDILQIVNREDPNWWQAC--HLAEGGTGLIPSQFLEEKRKAFVP 328

  Fly   314 TQKNGTDLDSKPGSCASLCTTPPGSPRLPASSSTSSCRQPKTKKIMYDLTENDDFDREQIATYEE 378
            ...:|..:         ||.|..|.               |.||:||...:|.:|||.::..|||
Zfish   329 RDLDGAGI---------LCGTMTGK---------------KKKKMMYLTAKNAEFDRHELQIYEE 369

  Fly   379 VAKLYPRPGVF--RPIVLIGAPGVGRNELRRRLIARDPEKFRSPVPYTTRPMRTGEVAGREYIFV 441
            ||::.|    |  :.::||||.||||..|:.||:...|.:|.:.||:|:|..|..|..|:.|.||
Zfish   370 VARMPP----FQRKTLILIGAQGVGRRSLKNRLVVLHPTRFGTTVPHTSRRPRNDERDGQSYRFV 430

  Fly   442 AREKMDADIEAGKFVEHGEYKGHLYGTSAESVKSIVNAGCVCVLSPHYQAIKTLRTAQLKPFLIH 506
            .|.:|:.||:.|:::|||||.|:||||..:|:..:||.|..|:|..:.||:|.|:|.:..|:::.
Zfish   431 TRLEMETDIKLGRYLEHGEYDGNLYGTKIDSIHEVVNTGRTCILDVNPQALKLLKTPEFMPYVVF 495

  Fly   507 VKPPELDILKATRTEARAKSTFDEA-NARSFTDEEFEDMIKSAERIDFLYGHFFDVELVNGELVN 570
            :..||.|.||...     |:..|.. ..:...|.:.:..:..:.||...|.|:||:.:||..|..
Zfish   496 IAAPEFDTLKDMH-----KAVVDAGLTTKQLADVDLKKTVDESARILRAYRHYFDLIIVNDNLDC 555

  Fly   571 AFEQLVQNVQRLENEPVWAPSMWV 594
            |||:|..:|:.|..||.|.|..||
Zfish   556 AFEKLQSSVEELCTEPQWVPVSWV 579

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
metro	NP_610642.2	L27	17..68	CDD:197794	13/52 (25%)
		L27	75..127	CDD:197794	15/51 (29%)
		PDZ_MPP3-MPP4-MPP7-like	140..230	CDD:467260	34/90 (38%)
		SH3_MPP	243..302	CDD:212796	33/58 (57%)
		Guanylate_kin	390..575	CDD:395500	70/185 (38%)
pals2b	XP_005170070.1	L27	43..96	CDD:197794	14/56 (25%)
		L27	98..149	CDD:460717	16/53 (30%)
		PDZ_MPP6-MPP2-like	170..248	CDD:467268	34/90 (38%)
		SH3_MPP	260..317	CDD:212796	33/58 (57%)
		Guanylate_kin	377..567	CDD:395500	72/194 (37%)