DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment metro and guk1b

DIOPT Version :9

Sequence 1:	NP_610642.2	Gene:	metro / 36176	FlyBaseID:	FBgn0050021	Length:	595	Species:	Drosophila melanogaster
Sequence 2:	NP_957018.1	Gene:	guk1b / 393697	ZFINID:	ZDB-GENE-020916-1	Length:	223	Species:	Danio rerio

Alignment Length:	228	Identity:	61/228 - (26%)
Similarity:	109/228 - (47%)	Gaps:	45/228 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   390 RPIVLIGAPGVGRNELRRRLIARDPEKFRSPVPYTTRPMRTGE---------------------- 432
            ||:||.|..|.|::.|.:||:......|...|.:|||..|.||
Zfish     5 RPVVLSGPSGAGKSTLLKRLMKEYEGVFGFSVSHTTRNPRPGEEDGKGLNCLPMLLGATLLPVAD 69

  Fly   433 ----VAGREYIFVAREKMDADIEAGKFVEHGEYKGHLYGTSAESVKSIVNAGCVCVLSPHYQAIK 493
                |...:|.||.:|||...|:..:|:|:.|:.|::||||..|::.:.....:|:|....|.::
Zfish    70 VLSSVTSEDYHFVTKEKMQEGIDKDEFIENAEFSGNMYGTSKSSIEDVQAQNLICILDVDIQGVR 134

  Fly   494 TLRTAQLKPFLIHVKPPELDILKATRTEARAKSTFDEANARSFTDEEFEDMIKSAERIDFLYGH- 557
            .::...|.|..|.::||.::||     |.|.:....|      |::..:..:::| |||.....
Zfish   135 NIKKTDLNPIYISIQPPSMEIL-----EKRLRDRQTE------TEDSLQKRLEAA-RIDMELSKE 187

  Fly   558 --FFDVELVNGELVNAFEQ----LVQNVQRLEN 584
              .||:.:||.:|..|:|:    |::.::::::
Zfish   188 PGVFDIVIVNDDLEEAYEKLKSVLIEEIEKVQD 220

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
metro	NP_610642.2	L27	17..68	CDD:197794
		L27	75..127	CDD:197794
		PDZ_signaling	139..229	CDD:238492
		SH3_MPP	243..302	CDD:212796
		Guanylate_kin	390..575	CDD:279019	60/217 (28%)
		GuKc	399..580	CDD:214504	56/213 (26%)
guk1b	NP_957018.1	Gmk	1..219	CDD:223272	61/225 (27%)
guk1b	NP_957018.1	guanyl_kin	5..213	CDD:213788	61/219 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810