Protein Alignment metro and Pals2

DIOPT Version :9

• Sequence 1: NP_610642.2
• Gene: metro / 36176
• FlyBaseID: FBgn0050021
• Length: 595
• Species: Drosophila melanogaster
• Sequence 2: XP_006236558.1
• Gene: Pals2 / 362359
• RGDID: 1311833
• Length: 554
• Species: Rattus norvegicus
• Alignment Length: 604
• Identity: 212/604 - (35%)
• Similarity: 327/604 - (54%)
• Gaps: 76/604 - (12%)

  Fly    16 LSKLISTLKESENLSNDQEID--FLKALLESKELNALVNVHTKVAKVGRDDRLAPVLSTSAQVLY 78
            :.:::..|.|..:.:..:|||  |||.::|:..:.:|...|.::    .|.:|..|...:.:::.
  Rat     1 MQQVLENLTELPSSTGAEEIDLIFLKGIMENPIVKSLAKAHERL----EDSKLEAVSDNNLELVN 61

  Fly    79 EVLEQLSQHCHLNDDCKEAFHLLQDSHLQHLLFAHDAIAQKDFY--PHLPEAPVEMDEDE----E 137
            |:||.::....::::..|...:|::.|.|.||.|||.:|.|.:.  |..||..:....::    :
  Rat    62 EILEDITPLISVDENVAELVGILKEPHFQSLLEAHDIVASKCYESPPSSPEMNIPSLNNQLLPVD 126

  Fly   138 TIKIVQLVK-SNEPLTGAQSTEPIVGATIKTDEESGKIIIARIMHGGAADRSGLIHVGDEVIEVN 201
            .|:|:.:.| :.|||          |.|.:.  |:..::||||:|||..||.||:||||.:.|||
  Rat   127 AIRILGIHKRAGEPL----------GVTFRV--ENNDLVIARILHGGMIDRQGLLHVGDIIKEVN 179

  Fly   202 NINVEGKTPGDVLTILQNSEGTITFKLVPA--DNKGAQRE-----------SKVRVRAHFDYNPD 253
            ...| |..|.::..:|:|..|::|.|::|:  |....|:.           .:|.|:.||||||.
  Rat   180 GHEV-GNNPKELQELLKNISGSVTLKILPSYRDTIAPQQSYVNMERHPAHVRQVFVKCHFDYNPF 243

  Fly   254 VDPYIPCKEAGLAFQRGDVLHIVAQDDAYWWQARKEHERSARAGLIPSRALQERRILHDRTQKNG 318
            .|..||||||||.|.:|::|.||.::|..||||....| ...||||||:.|:|:|....|
  Rat   244 NDNLIPCKEAGLKFSKGEILQIVNREDPNWWQASHVKE-GGSAGLIPSQFLEEKRKAFVR----- 302

  Fly   319 TDLDSKPGSCASLCTTPPGSPRLPASSSTSSCRQPKTKKIMYDLTENDDFDREQIATYEEVAKLY 383
            .|.|:....|.::                   ...|.||:||..|.|.:|||.:|..||||||:.
  Rat   303 RDWDNSGPFCGTI-------------------SNKKKKKMMYLTTRNAEFDRHEIQIYEEVAKMP 348

  Fly   384 PRPGVF--RPIVLIGAPGVGRNELRRRLIARDPEKFRSPVPYTTRPMRTGEVAGREYIFVAREKM 446
            |    |  :.:|||||.||||..|:.|.|..:|.:|.:.||:|:|..|..|..|:.|.||:|.:|
  Rat   349 P----FQRKTLVLIGAQGVGRRSLKNRFIVLNPARFGTTVPFTSRKPREDEKDGQAYKFVSRSEM 409

  Fly   447 DADIEAGKFVEHGEYKGHLYGTSAESVKSIVNAGCVCVLSPHYQAIKTLRTAQLKPFLIHVKPPE 511
            :|||:|||::|||||:|:||||...|:..:|..|..|:|..:.||:|.|||::..|:::.:..||
  Rat   410 EADIKAGKYLEHGEYEGNLYGTKIGSILDVVQTGRTCILDVNPQALKVLRTSEFMPYVVFIAAPE 474

  Fly   512 LDILKATRTEARAKSTFDEA-NARSFTDEEFEDMIKSAERIDFLYGHFFDVELVNGELVNAFEQL 575
            |:.|:|..     |:..|.. ..:..||.:.:..:..:.||...|.|:||:.:||..|..|||.|
  Rat   475 LETLRAMH-----KAVVDAGITTKLLTDSDLKKTVDESARIQRAYNHYFDLIIVNDNLDKAFENL 534

  Fly   576 VQNVQRLENEPVWAPSMWV 594
            ...:::|..||.|.|..||
  Rat   535 QTAIEKLRTEPQWVPISWV 553

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
metro	NP_610642.2	L27	17..68	CDD:197794	13/52 (25%)
		L27	75..127	CDD:197794	15/53 (28%)
		PDZ_signaling	139..229	CDD:238492	35/90 (39%)
		SH3_MPP	243..302	CDD:212796	32/58 (55%)
		Guanylate_kin	390..575	CDD:279019	75/185 (41%)
		GuKc	399..580	CDD:214504	71/181 (39%)
Pals2	XP_006236558.1	L27	2..55	CDD:197794	14/56 (25%)
		L27	57..108	CDD:397114	14/50 (28%)
		PDZ_signaling	133..206	CDD:238492	33/85 (39%)
		SH3_MPP6	233..293	CDD:212971	33/60 (55%)
		Guanylate_kin	351..541	CDD:395500	76/194 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352369
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740