DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment metro and magu-2

DIOPT Version :9

Sequence 1:	NP_610642.2	Gene:	metro / 36176	FlyBaseID:	FBgn0050021	Length:	595	Species:	Drosophila melanogaster
Sequence 2:	NP_001355433.1	Gene:	magu-2 / 3565703	WormBaseID:	WBGene00006467	Length:	830	Species:	Caenorhabditis elegans

Alignment Length:	681	Identity:	188/681 - (27%)
Similarity:	306/681 - (44%)	Gaps:	171/681 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 ENLSNDQEIDFLK-ALLESKELNALV-NVHTKVAKVGRDDRLA--PVLSTS-AQVLYEVLEQLSQ 86
            |....:||..||: :|.:||:|.||. ||          |.|.  |:..|| |..|.||.|..|:
Worm   204 EKKRKEQENTFLRSSLRKSKKLQALARNV----------DPLTNEPMKVTSFANPLAEVEETPSR 258

  Fly    87 HCH-------LNDDCKEAFHLLQDS------HLQHLLFAHDAIAQK---------------DFY- 122
            ...       :.::..|:..:|.|.      .|..::.:.:.||.|               ||:
Worm   259 KTENGATRITVGEEVLESSEVLIDEENKDSRQLDEVIISVERIASKLSSMQGRESDVAMLRDFFA 323

  Fly   123 -PHL-----------------------------------PEAPVEMD------------------ 133
             |.:                                   |..||.|:
Worm   324 APPIQAAIEQTVKQNGKCGTTSSGIGTDSGGDSSSCTSSPIPPVIMNGNGKSERCPSTSSSSSVS 388

  Fly   134 -EDEETIKIVQLVKSNEPLTGAQSTEPIVGATIKTDEESGKIIIARIMHGGAADRSGLIHVGDEV 197
             .:...:|:|::||..         :..:|||::  .|:.|||:.|::.||..::..|...|||:
Worm   389 PRNAPNVKVVEVVKDE---------DSYLGATVR--NENNKIIVGRVVKGGIVEKMNLFQEGDEL 442

  Fly   198 IEVNNINVEGKTPGDVLTILQNSEGTITFKLVP------------ADNKGAQRESKVRV---RAH 247
            :|:|..:::||...::..||:|..|.|||.:.|            |.|....::|:..|   ||.
Worm   443 LELNGSSLKGKQVNEICDILRNLSGPITFVVAPKEEQDTEQPTDTATNTVTAKKSQQHVQHLRAL 507

  Fly   248 FDYNPDVDPYIPCKEAGLAFQRGDVLHIVAQDDAYWWQARKEHE--RSARAGLIPSRALQERRIL 310
            |||:|:.|.|:||||..:.|||||:||::...|..||||.::.|  :.:.||||||.:.:::.:|
Worm   508 FDYDPEDDVYVPCKELAMKFQRGDILHVLNTKDDNWWQAYRDGEDIQHSLAGLIPSSSFRQQVVL 572

  Fly   311 H-DRTQKNGTDLDSKPGSCASLCTTPPGSPRLPASSSTSSCRQPKTKKIMYDLTENDDFDR---- 370
            : |..::.                         .......|:..|.||:  ::.:..|.:.
Worm   573 YADEVERE-------------------------QEQKRKECKGKKKKKL--EVKKGADEENLPAI 610

  Fly   371 ---EQIATYEEVAKLYPRPGVFRPIVLIGAPGVGRNELRRRLIARDPEKFRSPVPYTTRPMRTGE 432
               ....|||||....|:....|||||.||.|||..:||.||:..|......|||||:|..:.||
Worm   611 GVYSDFLTYEEVVLELPKATHRRPIVLCGAEGVGCLKLRDRLLESDRITLACPVPYTSRTPKEGE 675

  Fly   433 VAGREYIFVAREKMDADIEAGKFVEHGEYKGHLYGTSAESVKSIVNAGCVCVLSPHYQAIKTLRT 497
            ..|..|.||:::|...|.::|||||.|||:...|||:.:.|.:::..|..||::...:::..:|:
Worm   676 FNGVHYHFVSKQKFHEDAKSGKFVEFGEYQKFWYGTAKKDVVNVIERGKTCVMTLKAESLGAIRS 740

  Fly   498 AQLKPFLIHVKPPELDILKATRTEARAKSTFDEANARSFTDEEFEDMIKSAERIDFLYGHFFDVE 562
            ..::|::|.:..|.|.||   |.:...:.||      ...|:|.:.::..::.|:..|||.||..
Worm   741 PDIQPYIIFIAAPSLYIL---RRQREVEGTF------GVKDDELKAILTQSKSIEQKYGHLFDGI 796

  Fly   563 LVNGELVNAFEQLVQNVQRLENEPVWAPSMW 593
            :||.:...:|.:|.|.:.::..||:|.|:.|
Worm   797 IVNIDFEKSFRELKQILMKVNTEPMWVPATW 827

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
metro	NP_610642.2	L27	17..68	CDD:197794	15/44 (34%)
		L27	75..127	CDD:197794	15/116 (13%)
		PDZ_signaling	139..229	CDD:238492	29/89 (33%)
		SH3_MPP	243..302	CDD:212796	31/63 (49%)
		Guanylate_kin	390..575	CDD:279019	65/184 (35%)
		GuKc	399..580	CDD:214504	60/180 (33%)
magu-2	NP_001355433.1	PDZ	<59..107	CDD:238080
		PDZ_signaling	408..474	CDD:238492	25/67 (37%)
		SH3_MPP5	503..565	CDD:212969	31/61 (51%)
		GuKc	642..817	CDD:214504	60/183 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	150	1.000	Domainoid score	I2697
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000824
OrthoInspector	1	1.000	-	-		otm14545
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.810