Protein Alignment metro and vari

DIOPT Version :10

• Sequence 1: NP_610642.2
• Gene: metro / 36176
• FlyBaseID: FBgn0050021
• Length: 595
• Species: Drosophila melanogaster
• Sequence 2: NP_724288.3
• Gene: vari / 35343
• FlyBaseID: FBgn0250785
• Length: 636
• Species: Drosophila melanogaster
• Alignment Length: 654
• Identity: 191/654 - (29%)
• Similarity: 309/654 - (47%)
• Gaps: 134/654 - (20%)

  Fly    21 STLKESENLSNDQEIDFLKALLES------KELNALVNVHTKVAKVGRDDRLAPVLSTSAQVLYE 79
            :..:.|.:||:..|| |||.||.|      |||  ::| .|:...|   ....|....:..:..:
  Fly    36 AAFRNSTDLSDHDEI-FLKGLLRSNSNTPHKEL--MLN-PTEPQPV---PLFLPAHLNNKPICDD 93

  Fly    80 VLEQLSQHCHLNDDCKEAFHLLQDSHLQHLLFAHDAI---------------------AQKDFYP 123
            ::.:.|....|  :.:|...||...|.:.||.|||.|                     :|:....
  Fly    94 IIRKFSPSRRL--ESRELAKLLAQPHFRALLRAHDEIGALYEQRLKAAGGSTSQLEIASQRQTGG 156

  Fly   124 HL-------PEAPVEMDEDEETIKIVQLVKS-NEPLTGAQSTEPIVGATIKTDEESGKIIIARIM 180
            :|       .:.||      ||||:|.|.:. ::||          |.|::.||.. ::::|||:
  Fly   157 YLFTEDVLNTKMPV------ETIKMVGLRRDPSKPL----------GLTVELDEFK-QLVVARIL 204

  Fly   181 HGGAADRSGLIHVGDEVIEVNNINVEGKTPGDVLTILQNSEGTITFKLVP-ADNK---------G 235
            .||..|:..::||||.::|||...|  :||.::...:..::..:|.|:.| .|.:         |
  Fly   205 AGGVIDKQSMLHVGDVILEVNGTPV--RTPDELQVEVSRAKENLTLKIGPNVDEEIKSGRYTVSG 267

  Fly   236 AQ------------RESKVRVRAHFDYNPDVDPYIPCKEAGLAFQRGDVLHIVAQDDAYWWQARK 288
            .|            ::....:||.|.|||..|..:||::.||.|:.||:|.|:...|..||||:.
  Fly   268 GQVKQNGIASLETGKKLTCYMRALFTYNPSEDSLLPCRDIGLPFKSGDILQIINVKDPNWWQAKN 332

  Fly   289 EHERSARAGLIPSRALQERRILHDRTQKNGTDLDSKPGSCASLCTTPPGSPRLPASSSTSSCRQP 353
            ....|.:.|||||:.|:|||......:   .|...|.|.|.:..:                   .
  Fly   333 ITAESDKIGLIPSQELEERRKAFVAPE---ADYVHKIGICGTRIS-------------------K 375

  Fly   354 KTKKIMYDLTENDDFDREQIATYEEVAKLYPRPGVFR--PIVLIGAPGVGRNELRRRLIARDPEK 416
            :.:|.||....|.:||:.::..||||.::.|    ||  .:||||..||||..|:.|||..|.:|
  Fly   376 RKRKTMYRSVANCEFDKAELLLYEEVTRMPP----FRRKTLVLIGVSGVGRRTLKNRLINSDVDK 436

  Fly   417 FRSPVPYTTRPMRTGEVAGREYIFVAREKMDADIEAGKFVEHGEYKGHLYGTSAESVKSIVNAGC 481
            |.:.:|:|:||.|..|..|..|.|:.||:|:..:...:|:|:||:.|:||||..:|:|.::|:|.
  Fly   437 FGAVIPHTSRPKRALEENGSSYWFMDREEMEEAVRNNEFLEYGEHNGNLYGTHLQSIKDVINSGR 501

  Fly   482 VCVLSPHYQAIKTLRTAQ-LKPFLIHVKPPELDILKATRTEARAKS-----TFDEANARSFTDE- 539
            :|:|.....|:|.|..:| |.||:|.|..|.::.||....:.||..     :||..::..|:..
  Fly   502 MCILDCAPNALKILHNSQELMPFVIFVAAPGMEQLKTIYADRRATGSNRNLSFDRQSSIRFSSRR 566

  Fly   540 -----------EFEDMIKSAERIDFL---YGHFFDVELVNGELVNAFEQLVQNVQRLENEPVWAP 590
                       |.:|::.:.|...|:   |..:||:.:||.:....|.|:|:.:.::.:|..|.|
  Fly   567 ARTLESLASLYEDDDLVATVEESSFVQRKYEKYFDMVIVNEDFDETFRQVVETLDQMSHEEQWVP 631

  Fly   591 SMWV 594
            ..|:
  Fly   632 VNWI 635

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
metro	NP_610642.2	L27	17..68	CDD:197794	17/52 (33%)
		L27	75..127	CDD:197794	14/79 (18%)
		PDZ_MPP3-MPP4-MPP7-like	140..230	CDD:467260	27/90 (30%)
		SH3_MPP	243..302	CDD:212796	26/58 (45%)
		Guanylate_kin	390..575	CDD:395500	70/207 (34%)
vari	NP_724288.3	L27	<105..128	CDD:460717	9/22 (41%)
		PDZ_MPP6-MPP2-like	174..252	CDD:467268	27/90 (30%)
		SH3_MPP	287..347	CDD:212796	27/59 (46%)
		Guanylate_kin	408..622	CDD:395500	72/213 (34%)