DRSC/TRiP Functional Genomics Resources

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Protein Alignment metro and mpp1

DIOPT Version :10

Sequence 1:NP_610642.2 Gene:metro / 36176 FlyBaseID:FBgn0050021 Length:595 Species:Drosophila melanogaster
Sequence 2:NP_999857.2 Gene:mpp1 / 325542 ZFINID:ZDB-GENE-031113-4 Length:468 Species:Danio rerio


Alignment Length:439 Identity:145/439 - (33%)
Similarity:230/439 - (52%) Gaps:53/439 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly   157 TEPIVGATIKTDEESGKIIIARIMHGGAADRSGLIHVGDEVIEVNNINVEGKTPGDVLTILQNSE 221
            :||: |.|:|.:|:. :..:|||:|||...|.|.:|.|||:.|:|..:|..::...:..||:::.
Zfish    81 SEPL-GVTLKLNEKQ-RCTVARILHGGMIHRQGSLHEGDEIAEINGKSVSNQSVDQLQKILKDTN 143

  Fly   222 GTITFKLVPADNKGAQRESKVRVRAHFDYNPDVDPYIPCKEAGLAFQRGDVLHIVAQDDAYWWQA 286
            |.:|.|:: ::.:......::.:||.|||:|..|..||||||||.||.||::||:.:.|..|||.
Zfish   144 GVVTLKII-SNQQSRPMACEMYMRAQFDYDPAKDELIPCKEAGLKFQTGDIIHIINKKDPNWWQG 207

  Fly   287 RKEHERSARAGLIPSRALQERRILHDRTQKNGTDLDSKPGSCASLCTTPPGSPRLPASSSTSSCR 351
            :.:...:..||||||..|||.|:                 :..|..|...|       .|.|...
Zfish   208 KVDSSSTDFAGLIPSPELQEWRV-----------------ASKSKATREAG-------QSCSPFG 248

  Fly   352 QPKTKKIMYDLTENDDFDREQIATYEEVAKLYPRPGVFR-PIVLIGAPGVGRNELRRRLIARDPE 415
            :.|..|..|....:..||:..:.:||||.:|   |...| .:|||||.||||:.::..|:::.||
Zfish   249 KKKKCKDKYLAKHSSIFDQLDVISYEEVVRL---PAFNRKTLVLIGAHGVGRSLIKNSLLSKYPE 310

  Fly   416 KFRSPVPYTTRPMRTGEVAGREYIFVAREKMDADIEAGKFVEHGEYKGHLYGTSAESVKSIVNAG 480
            ||..|.|:||||.:..|..|:||.|::.::|...|...:.:|:|.|:||::||..|::..|...|
Zfish   311 KFAYPAPHTTRPQKKDEENGKEYYFISNDEMTKGIVGNELLEYGSYQGHMFGTKIETIHKIHEQG 375

  Fly   481 CVCVLSPHYQAIKTLRTAQLKPFLIHVKPPELDILKATRTEARAKSTFDEANARSFTDEEFEDMI 545
            .:.||....|.:|.||||:..|.:|.:.|               .:|.:::.|.....:| .|.:
Zfish   376 KIAVLDVEPQTLKVLRTAEFAPLVIFIAP---------------TNTGNQSEAVQNIQKE-SDSL 424

  Fly   546 KSAERIDFLYGHFFDVELVNGELVNAFEQLVQNVQRLENEPVWAPSMWV 594
            .:|.|      ||||..|||.::..:.:.:...::|..:.|.|.|..||
Zfish   425 LAAHR------HFFDEILVNNDVDESVKGVEDAIERASSSPQWVPISWV 467

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
metroNP_610642.2 L27 17..68 CDD:197794
L27 75..127 CDD:197794
PDZ_MPP3-MPP4-MPP7-like 140..230 CDD:467260 26/72 (36%)
SH3_MPP 243..302 CDD:212796 30/58 (52%)
Guanylate_kin 390..575 CDD:395500 62/185 (34%)
mpp1NP_999857.2 PDZ_MPP1-like 72..152 CDD:467266 26/73 (36%)
SH3_MPP1 164..225 CDD:213013 31/60 (52%)
Guanylate_kin 284..453 CDD:395500 62/190 (33%)
Blue background indicates that the domain is not in the aligned region.

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