DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment metro and mpp1

DIOPT Version :9

Sequence 1:	NP_610642.2	Gene:	metro / 36176	FlyBaseID:	FBgn0050021	Length:	595	Species:	Drosophila melanogaster
Sequence 2:	NP_999857.1	Gene:	mpp1 / 325542	ZFINID:	ZDB-GENE-031113-4	Length:	468	Species:	Danio rerio

Alignment Length:	439	Identity:	146/439 - (33%)
Similarity:	230/439 - (52%)	Gaps:	53/439 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   157 TEPIVGATIKTDEESGKIIIARIMHGGAADRSGLIHVGDEVIEVNNINVEGKTPGDVLTILQNSE 221
            :||: |.|:|.:|:. :..:|||:|||...|.|.:|.|||:.|:|..:|..::...:..||:::.
Zfish    81 SEPL-GVTLKLNEKQ-RCTVARILHGGMIHRQGSLHEGDEIAEINGKSVSNQSVDQLQKILKDTN 143

  Fly   222 GTITFKLVPADNKGAQRESKVRVRAHFDYNPDVDPYIPCKEAGLAFQRGDVLHIVAQDDAYWWQA 286
            |.:|.|:: ::.:......::.:||.|||:|..|..||||||||.||.||::||:.:.|..|||.
Zfish   144 GVVTLKII-SNQQSRPMACEMYMRAQFDYDPAKDELIPCKEAGLKFQTGDIIHIINKKDPNWWQG 207

  Fly   287 RKEHERSARAGLIPSRALQERRILHDRTQKNGTDLDSKPGSCASLCTTPPGSPRLPASSSTSSCR 351
            :.:...:..||||||..|||.|:                 :..|..|...|       .|.|...
Zfish   208 KVDSSSTDFAGLIPSPELQEWRV-----------------ASKSKATREAG-------QSCSPFG 248

  Fly   352 QPKTKKIMYDLTENDDFDREQIATYEEVAKLYPRPGVFR-PIVLIGAPGVGRNELRRRLIARDPE 415
            :.|..|..|....:..||:..:.:||||.:|   |...| .:|||||.||||:.::..|:::.||
Zfish   249 KKKKCKDKYLAKHSSIFDQLDVISYEEVVRL---PAFNRKTLVLIGAHGVGRSLIKNSLLSKYPE 310

  Fly   416 KFRSPVPYTTRPMRTGEVAGREYIFVAREKMDADIEAGKFVEHGEYKGHLYGTSAESVKSIVNAG 480
            ||..|.|:||||.:..|..|:||.|::.::|...|...|.:|:|.|:||::||..|::..|...|
Zfish   311 KFAYPAPHTTRPQKKDEENGKEYYFISNDEMTKGIVGNKLLEYGSYQGHMFGTKIETIHKIHEQG 375

  Fly   481 CVCVLSPHYQAIKTLRTAQLKPFLIHVKPPELDILKATRTEARAKSTFDEANARSFTDEEFEDMI 545
            .:.||....|.:|.||||:..|.:|.:.|               .:|.:::.|.....:| .|.:
Zfish   376 KIAVLDVEPQTLKVLRTAEFAPLVIFIAP---------------TNTGNQSEAVQNIQKE-SDSL 424

  Fly   546 KSAERIDFLYGHFFDVELVNGELVNAFEQLVQNVQRLENEPVWAPSMWV 594
            .:|.|      ||||..|||.::..:.:.:...::|..:.|.|.|..||
Zfish   425 LAAHR------HFFDEILVNNDVDESVKGVEDAIERASSSPQWVPISWV 467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
metro	NP_610642.2	L27	17..68	CDD:197794
		L27	75..127	CDD:197794
		PDZ_signaling	139..229	CDD:238492	26/71 (37%)
		SH3_MPP	243..302	CDD:212796	30/58 (52%)
		Guanylate_kin	390..575	CDD:279019	63/185 (34%)
		GuKc	399..580	CDD:214504	57/180 (32%)
mpp1	NP_999857.1	PDZ	73..151	CDD:278991	26/71 (37%)
		SH3_MPP1	164..225	CDD:213013	31/60 (52%)
		Guanylate_kin	284..453	CDD:279019	63/190 (33%)
		GuKc	293..453	CDD:214504	57/181 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594310
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840