DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment metro and Card10

DIOPT Version :9

Sequence 1:	NP_610642.2	Gene:	metro / 36176	FlyBaseID:	FBgn0050021	Length:	595	Species:	Drosophila melanogaster
Sequence 2:	XP_038935185.1	Gene:	Card10 / 315120	RGDID:	1304949	Length:	1109	Species:	Rattus norvegicus

Alignment Length:	423	Identity:	86/423 - (20%)
Similarity:	141/423 - (33%)	Gaps:	143/423 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   149 EPLTGAQSTEPIVGATIKTDEESGKIIIARIMHGGA----------ADRSGLIHVGDEVIEVNNI 203
            :|...:..:.||:|     |..|| .::.|::.|..          |:.|||...|.|. ||..
  Rat   691 DPQDKSPDSLPILG-----DRWSG-AVVRRVLSGPGSARTEQKEPRAEGSGLEGTGLEA-EVQQ- 747

  Fly   204 NVEGKTPGDVLTILQNSEGTITFKLVPADNKGAQR-------------ESKVRVRAHFDYNPDVD 255
                      .|:..|...|:.|.|   |:|..|.             .....:||:|......|
  Rat   748 ----------RTLPWNQSSTLPFLL---DSKACQSFHEALDVWAKGPGAEPFYIRANFSLPERAD 799

  Fly   256 PYIPCKEAGLAFQRGDVLHIVAQDDAY-----WWQARKE--HERSARAGLIPS--RA-----LQE 306
            |:..|.:|      .::|.:|  |.||     |:..|.:  ..|....|.:|:  ||     :||
  Rat   800 PHALCVKA------QEILRLV--DPAYKRRQEWFCTRVDTLTLRDLDRGTVPNYQRAQQLLEVQE 856

  Fly   307 RRILHDRTQKNGTDLDS--------KPGSCASLCTTPPGSPRLPASSSTSSCRQPKTKKIMYDLT 363
            :.::..|.:...::|..        ||..    .|....:.:|||    ..|.:.:.....|.|.
  Rat   857 KYLISSRHRSPRSNLKKRALGLVRPKPAG----GTAGDSAEQLPA----DPCSELERSLKPYSLV 913

  Fly   364 ENDDFDREQIATYEEVAKLYPRP---GVFRPIVLIG---APGVGRNELRRRLIARDPEKFRSPVP 422
                                 ||   ...||:||:.   ||.:.||.|       |....|....
  Rat   914 ---------------------RPLLVSALRPVVLLPECLAPRLIRNLL-------DLPSSRLDFQ 950

  Fly   423 YTTRPMRTGE------VAGREYIFVAREKMDADIEAGKFVEHGEYKGHLYGTSAESVKSIVNAGC 481
            ..:....:||      ..|....:.|...:.:.|.|   ::....|.|
  Rat   951 VCSAESLSGEEQCTSSAPGAPKAWPASAGLGSRIRA---IQESVGKKH----------------- 995

  Fly   482 VCVLSPHYQAIKTLRTAQLKPFLIHVKPPELDI 514
             |:|....:.::.|..:::.|.:|||:..|.::
  Rat   996 -CLLELGARGVRELVHSEVYPIVIHVEVTEKNV 1027

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
metro	NP_610642.2	L27	17..68	CDD:197794
		L27	75..127	CDD:197794
		PDZ_signaling	139..229	CDD:238492	21/89 (24%)
		SH3_MPP	243..302	CDD:212796	17/67 (25%)
		Guanylate_kin	390..575	CDD:279019	27/134 (20%)
		GuKc	399..580	CDD:214504	21/122 (17%)
Card10	XP_038935185.1	CARD_CARD10_CARMA3	76..161	CDD:260069
		Smc	<196..>499	CDD:224117
		SH3	784..849	CDD:418401	18/72 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900