Protein Alignment metro and Dlg5

DIOPT Version :9

• Sequence 1: NP_610642.2
• Gene: metro / 36176
• FlyBaseID: FBgn0050021
• Length: 595
• Species: Drosophila melanogaster
• Sequence 2: NP_001358932.1
• Gene: Dlg5 / 305645
• RGDID: 1308753
• Length: 1925
• Species: Rattus norvegicus
• Alignment Length: 561
• Identity: 123/561 - (21%)
• Similarity: 229/561 - (40%)
• Gaps: 114/561 - (20%)

  Fly    80 VLEQLSQHCH-LNDDCKEAFHLLQDSHLQHLLFAHDAI----AQKDFYPHLPEAPVEMDEDEETI 139
            :|.|.:.|.| ||.      |....|||......|..:    |....:|.:.:..:|.||...|.
  Rat  1427 ILAQYNPHIHQLNS------HSRSSSHLDPAAAPHSTLQGSSAATPEHPSVIDPLMEQDEGPGTP 1485

  Fly   140 KIVQLVKSNEPLTGA--QSTEPIVGATIKTDEESGKIIIARIMHG----------GAADRSGLIH 192
            ...|...|:..:..|  ::.||.:....|:..:.|..:....:||          .|....||:
  Rat  1486 PAKQSTPSSRIVGDASKKTPEPRIVFIKKSQLDLGVQLCGGNLHGVFVAEVEDDSPAKGPDGLV- 1549

  Fly   193 VGDEVIEVNNINVEGKTPGDVLTILQNSEGTITFKLVPADN-----KGAQRESKVRVRAHFDYNP 252
            .||.::|..|:::..:|..||...:...:.:|..|:.....     ||...:| ..:||.:|...
  Rat  1550 PGDLILEYGNLDMRSRTLEDVYVEMMKPKDSIRLKVQYRHEEFTRVKGLSGDS-FYIRALYDRLA 1613

  Fly   253 DVDPYIPCKEAGLAFQRGDVLHIVAQDDAY-------W--WQARKEHERSARAGLIPSRALQE-- 306
            :|:|       .|:|::.|:|::   ||..       |  ||. .|:.:..:.|.|||:.:.:
  Rat  1614 EVEP-------ELSFKKDDILYV---DDTLPQGMFGSWMAWQL-DENAQKIQRGQIPSKYVMDQE 1667

  Fly   307 --RRILHDRTQKNGTDLDSKPGSCASLCTTPPGSPRLPASSSTSSCRQP-KTK----KIMYDLTE 364
              ||:.....:.:.|                  :..|.|::..|..|:. |.|    |...||..
  Rat  1668 FSRRLSMSEVKDDNT------------------AKMLSAAARRSFFRRKHKHKRSGSKDSKDLLS 1714

  Fly   365 NDDFDREQIATYEE-VAKLYPRP-----GVFRPIVLIGAPGVGRNELRRRLIARDPEKF-RSPVP 422
            .|.|..:.|..:|: |:..|.|.     ...||::::| |.:  :.::..|:...|.|| |.|:
  Rat  1715 LDTFSNDSIPLFEDSVSLAYQRVQKVDCTSLRPVLILG-PLL--DVVKEMLVNEAPGKFCRCPL- 1775

  Fly   423 YTTRPMRTGEVAGREYIFVAREKMDADIEAGKFVEHGEYKGHLYGTSAESVKSIV--NAGCVCVL 485
                          |.:..:::.::..::...||::....||...|:..|:|.|.  |..|:..:
  Rat  1776 --------------EVMKASQQAIERGVKDCLFVDYKRRSGHFDVTTVASIKEITEKNRHCLLDI 1826

  Fly   486 SPHYQAIKTLRTAQLKPFLIHVKPPELDILKATRTEARAKSTFDEANARSFTDEEFEDMIKSAER 550
            :||  ||:.|....:.|.:|.::......:|..|.....:....:.:::    |:||    :|::
  Rat  1827 APH--AIERLHHMHIYPIVIFIRYKSAKHIKEQRDPVYLRDKVTQRHSK----EQFE----TAQK 1881

  Fly   551 IDFLYGHFFDVELVNGELVNAFEQLVQNVQRLENEPVWAPS 591
            ||..|..:|...:..|.|.:...|::..|.:.:::.:|.|:
  Rat  1882 IDQEYSRYFTGVVQGGALSSICTQILAMVSQEQSKVLWIPA 1922

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
metro	NP_610642.2	L27	17..68	CDD:197794
		L27	75..127	CDD:197794	13/51 (25%)
		PDZ_signaling	139..229	CDD:238492	21/101 (21%)
		SH3_MPP	243..302	CDD:212796	18/67 (27%)
		Guanylate_kin	390..575	CDD:279019	40/187 (21%)
		GuKc	399..580	CDD:214504	37/183 (20%)
Dlg5	NP_001358932.1	Takusan	129..213	CDD:398477
		Smc	<141..564	CDD:224117
		Cep57_CLD_2	<545..585	CDD:372959
		PDZ_signaling	620..707	CDD:238492
		PDZ_signaling	722..790	CDD:238492
		PDZ	1351..1433	CDD:214570	2/5 (40%)
		dbPDZ_assoc	1431..1506	CDD:406907	18/80 (23%)
		PDZ	1506..1588	CDD:214570	18/82 (22%)
		SH3_DLG5	1604..1666	CDD:212794	19/72 (26%)
		GuKc	1738..1914	CDD:214504	42/203 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910