DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment metro and Guk1

DIOPT Version :9

Sequence 1:	NP_610642.2	Gene:	metro / 36176	FlyBaseID:	FBgn0050021	Length:	595	Species:	Drosophila melanogaster
Sequence 2:	XP_006246539.1	Gene:	Guk1 / 303179	RGDID:	1309638	Length:	266	Species:	Rattus norvegicus

Alignment Length:	194	Identity:	69/194 - (35%)
Similarity:	97/194 - (50%)	Gaps:	21/194 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   390 RPIVLIGAPGVGRNELRRRLIARDPEKFRSPVPYTTRPMRTGEVAGREYIFVAREKMDADIEAGK 454
            ||:||.|..|.|::.|.::|.......|...|.:|||..|.||..|::|.||.||.|..||.||.
  Rat    73 RPVVLSGPSGAGKSTLLKKLFQEHGSVFGFSVSHTTRNPRPGEEDGKDYYFVTREMMQRDIAAGD 137

  Fly   455 FVEHGEYKGHLYGTSAESVKSIVNAGCVCVLSPHYQAIKTLRTAQLKPFLIHVKPPELDIL---- 515
            |:||.|:.|:|||||.|:|:::.....:|||....|.:::::...|.|..|.|:||.:|:|
  Rat   138 FIEHAEFSGNLYGTSKEAVRAVQAMNRICVLDVDLQGVRSIKKTDLHPIYISVQPPSMDVLEQRL 202

  Fly   516 --KATRTEARAKSTFDEANARSFTDEEFEDMIKSAERIDFLYGHFFDVELVNGELVNAFEQLVQ 577
              :.|.||.........|.|         ||..|.|      ...||:.:||..|..|:..|.|
  Rat   203 RQRNTETEESLAKRLAAAQA---------DMESSKE------PGLFDLVIVNDNLDEAYVTLKQ 251

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
metro	NP_610642.2	L27	17..68	CDD:197794
		L27	75..127	CDD:197794
		PDZ_signaling	139..229	CDD:238492
		SH3_MPP	243..302	CDD:212796
		Guanylate_kin	390..575	CDD:279019	67/190 (35%)
		GuKc	399..580	CDD:214504	64/185 (35%)
Guk1	XP_006246539.1	Guanylate_kin	71..256	CDD:279019	69/194 (36%)
Guk1	XP_006246539.1	guanyl_kin	73..255	CDD:213788	69/194 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810