DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment metro and mpp7a

DIOPT Version :9

Sequence 1:	NP_610642.2	Gene:	metro / 36176	FlyBaseID:	FBgn0050021	Length:	595	Species:	Drosophila melanogaster
Sequence 2:	XP_021335692.1	Gene:	mpp7a / 30166	ZFINID:	ZDB-GENE-991209-8	Length:	621	Species:	Danio rerio

Alignment Length:	632	Identity:	236/632 - (37%)
Similarity:	365/632 - (57%)	Gaps:	67/632 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 PALS----------KLISTLKE--SENLSNDQEIDFLKALLESKELNALVNVHTKVAKVGRDDRL 66
            ||||          :|:|.|..  ..::.:..:..||.|:...:.|::||.:|.|: :...|...
Zfish     2 PALSSRSGSEMGLYELLSVLPSQLQPHVESPDDRSFLHAMFGERSLHSLVKIHEKL-QCYEDCAP 65

  Fly    67 APVLSTSAQVLYEVLEQLSQHCHLNDDCKEAFHLLQDSHLQHLLFAHDAIAQKDFYPHLPEAPVE 131
            .|||.::..:..::.|:| |....:::.:|...||...|::.||..||.:|:|.:.|.||..|.:
Zfish    66 TPVLDSAGSLAADLTEEL-QARSASNEIRELVKLLSKPHVKSLLSVHDTVAKKSYDPELPPLPDD 129

  Fly   132 MDEDEETIKIVQLVKSNEPLTGAQSTEPIVGATIKTDEESGKIIIARIMHGGAADRSGLIHVGDE 196
            :|::|:::||::|||:.|||          |||||.||.:|.|::|||:.|||||||||||||||
Zfish   130 IDDEEDSVKIIRLVKNKEPL----------GATIKKDEHTGAILVARILRGGAADRSGLIHVGDE 184

  Fly   197 VIEVNNINVEGKTPGDVLTILQNSEGTITFKLVPADNKGAQ-RESKVRVRAHFDYNPDVDPYIPC 260
            :.|||.|.|:.|.|.:::.||..|:|.||||:||.....|| :|.|:.::|.|||||..|..|||
Zfish   185 LKEVNGIPVDDKKPEEIIRILSQSQGAITFKVVPGIKDEAQSKEPKMFIKALFDYNPAEDKAIPC 249

  Fly   261 KEAGLAFQRGDVLHIVAQDDAYWWQARKEHERSARAGLIPSRALQERRI---------------- 309
            |||||.|::||:|.:::||||.||||:.|.:.:.|||||||:..||||:
Zfish   250 KEAGLGFKKGDILQVMSQDDATWWQAKLEGDGNLRAGLIPSKHFQERRLAVWRPTPVMTLQRTSS 314

  Fly   310 --LHDRTQKNGTDLDSKPGSCASLCTTPPGSPRLPASSSTSSCRQPKTKKIMYDLTENDDFDREQ 372
              .:|.|.....|::.:....:.|........|   .|...|.|..||.|.||:..:::.:|...
Zfish   315 KRFYDDTVNCVEDIEEENEFASYLSGLHVAGLR---RSFRLSRRDKKTNKSMYECKKSEQYDTAD 376

  Fly   373 IATYEEVAKLYPRPG-VFRPIVLIGAPGVGRNELRRRLIARDPEKFRSPVPYTTRPMRTGEVAGR 436
            :.|||||.....:.| ..|.:||:|..|||.|||:|:|:..|.:.|...:|:|:|..|..|..|.
Zfish   377 VPTYEEVTTYRRKHGDRHRLVVLVGPTGVGLNELKRKLLISDTQHFSVTIPHTSRSKRHQESEGV 441

  Fly   437 EYIFVAREKMDADIEAGK-------------------FVEHGEYKGHLYGTSAESVKSIVNAGCV 482
            ||.|:::...:|||:..|                   |:|||||||:.||||.:||:|:::...|
Zfish   442 EYHFISKNLFEADIQNNKKSGYSCFWRSSLPVLQRNRFIEHGEYKGNYYGTSFDSVRSVLSKNKV 506

  Fly   483 CVLSPHYQAIKTLRTAQLKPFLIHVKPPELDILKATRTEARAKS-TFDEANARSFTDEEFEDMIK 546
            |:|......:|.||||:.||:::.||||.::.|:.||..|:..| ..|:.::::|::|:|.:||.
Zfish   507 CLLDVQPHTLKHLRTAEFKPYVVFVKPPCIERLRETRRNAKVISGKDDKTSSKAFSEEDFLEMIS 571

  Fly   547 SAERIDFLYGHFFDVELVNGELVNAFEQLVQNVQRLENEPVWAPSMW 593
            :::.::..|||.|:..:||.:|..||.:|.|.::::|.|..|.|..|
Zfish   572 ASQMMENQYGHLFEKVIVNDDLTVAFSELKQALKKVETEAHWVPISW 618

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
metro	NP_610642.2	L27	17..68	CDD:197794	13/62 (21%)
		L27	75..127	CDD:197794	15/51 (29%)
		PDZ_signaling	139..229	CDD:238492	50/89 (56%)
		SH3_MPP	243..302	CDD:212796	34/58 (59%)
		Guanylate_kin	390..575	CDD:279019	76/204 (37%)
		GuKc	399..580	CDD:214504	74/200 (37%)
mpp7a	XP_021335692.1	L27	12..68	CDD:197794	12/56 (21%)
		L27	74..125	CDD:197794	15/51 (29%)
		PDZ_signaling	137..217	CDD:238492	50/89 (56%)
		SH3	232..292	CDD:327375	35/59 (59%)
		GuKc	403..608	CDD:214504	74/204 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594307
Domainoid	1	1.000	94	1.000	Domainoid score	I7412
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1455
Inparanoid	1	1.050	420	1.000	Inparanoid score	I1768
OMA	1	1.010	-	-		QHG49437
OrthoDB	1	1.010	-	-		D245552at33208
OrthoFinder	1	1.000	-	-		FOG0000824
OrthoInspector	1	1.000	-	-		otm24780
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR23122
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5259
SonicParanoid	1	1.000	-	-		X2258
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	14.040