DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment metro and Magi3

DIOPT Version :9

Sequence 1:	NP_610642.2	Gene:	metro / 36176	FlyBaseID:	FBgn0050021	Length:	595	Species:	Drosophila melanogaster
Sequence 2:	NP_620784.3	Gene:	Magi3 / 245903	RGDID:	621362	Length:	1470	Species:	Rattus norvegicus

Alignment Length:	420	Identity:	77/420 - (18%)
Similarity:	114/420 - (27%)	Gaps:	210/420 - (50%)

- Green bases have known domain annotations that are detailed below.

  Fly   161 VGATIKTDEESGKI-IIARIMH--GGAADRSGLI-----HVGDEVIEVNNINVEGKTPGDVLTIL 217
            :||.|:...|.|:. .:.|:..  ||......::     ..||.::|||...|.|.|..|.|.::
  Rat    29 LGAEIRGGAERGEFPYLGRLRDEPGGGGGTCCVVSGKAPSPGDVLLEVNGTPVSGLTNRDTLAVI 93

  Fly   218 QNSEGTITFKLVPADNKGAQRESKVRVRAHFDYNPDVDPYIPCKEAGLAFQRGDVLHIVAQDDAY 282
            ::....|..|.|        :..||       .|.|:..|:     .|.||:|.:.|
  Rat    94 RHFREPIRLKTV--------KPGKV-------INKDLRHYL-----SLQFQKGSIDH-------- 130

  Fly   283 WWQARKEHERSARAGLIPSRALQERRILHDRTQKNGTDLDSKPGSCASLCTTPPGSPRLPASSST 347

  Rat   131 ----------------------------------------------------------------- 130

  Fly   348 SSCRQPKTKKIMYDLTENDDFDREQIATYEEVAKLYPRPGVFRPIVLIGAPGVGRNELRRRLIAR 412
                  |.::::.|                   .||.|
  Rat   131 ------KLQQVIRD-------------------NLYLR--------------------------- 143

  Fly   413 DPEKFRSPVPYTTRPMRTGEVAGREYIFVAREKMDADIEAGKFVEHGEYKGHLYGTSAESVKSIV 477
                   .:|.|||..|.|||.|.:|.|::.|:..|..|:|..:|.|.|.|:.|||...
  Rat   144 -------TIPCTTRAPRDGEVPGVDYNFISVEQFKALEESGALLESGTYDGNFYGTPKP------ 195

  Fly   478 NAGCVCVLSPHYQAIKTLRTAQLKPFLIHVKPPELDIL---KATRTEARAKSTFDEANAR---SF 536
                               .|:..||    :|..:|.:   ....||::.|.|...:...   |.
  Rat   196 -------------------PAEPSPF----QPDPVDQVLFDNEFDTESQRKRTTSVSKMERMDSS 237

  Fly   537 TDEEFEDMIKSAERIDFLYGHFFDVELVNG 566
            ..||.||.               |.|.|||
  Rat   238 LPEEEEDE---------------DKEAVNG 252

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
metro	NP_610642.2	L27	17..68	CDD:197794
		L27	75..127	CDD:197794
		PDZ_signaling	139..229	CDD:238492	20/75 (27%)
		SH3_MPP	243..302	CDD:212796	8/58 (14%)
		Guanylate_kin	390..575	CDD:279019	41/183 (22%)
		GuKc	399..580	CDD:214504	41/174 (24%)
Magi3	NP_620784.3	Interaction with ADRB1 and TGFA. /evidence=ECO:0000269\|PubMed:16316992	18..108		21/86 (24%)
		PDZ_signaling	24..103	CDD:238492	19/73 (26%)
		NK	125..>199	CDD:418433	30/230 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	184..266		24/113 (21%)
		HUL4	<211..>373	CDD:227354	14/57 (25%)
		WW	299..329	CDD:238122
		WW	345..375	CDD:238122
		Interaction with PTEN. /evidence=ECO:0000250	413..495
		PDZ	416..496	CDD:214570
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	550..575
		PDZ	578..659	CDD:214570
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	665..700
		PDZ	729..812	CDD:214570
		Interaction with ADGRB1. /evidence=ECO:0000250	729..811
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	818..847
		PDZ_signaling	851..936	CDD:238492
		Interaction with LPAR2 and GRIN2B. /evidence=ECO:0000250	852..939
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	939..976
		PDZ_signaling	1023..1101	CDD:238492
		PTZ00112	1115..>1405	CDD:240274
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1124..1146
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1167..1470
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900