Protein Alignment metro and PDZD2

DIOPT Version :9

• Sequence 1: NP_610642.2
• Gene: metro / 36176
• FlyBaseID: FBgn0050021
• Length: 595
• Species: Drosophila melanogaster
• Sequence 2: XP_005248326.1
• Gene: PDZD2 / 23037
• HGNCID: 18486
• Length: 2873
• Species: Homo sapiens
• Alignment Length: 512
• Identity: 91/512 - (17%)
• Similarity: 159/512 - (31%)
• Gaps: 187/512 - (36%)

  Fly   123 PHLPEAPVEMDEDEETIKIVQLVKSNEPLTGA--------------QSTEPI----VGATIKTD- 168
            |||..:.|:...:.      ::.|::.|||.:              ||::.:    ||...|.:
Human   279 PHLERSEVDRGTEH------RIPKTDAPLTTSNDKRRFSKGGKTDFQSSDCLAREEVGRIWKMEL 337

  Fly   169 --EESG----------------KIIIARIMHGGAADRSGLIHVGDEVIEVNNINVEGKTPGDVLT 215
              |..|                .|::.::..||||.|.|.:.:|||::.:|...:.|.:..:.:.
Human   338 LKESDGLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHEEAVA 402

  Fly   216 ILQNSEGTITFKLVPADNKGAQRESKVRVRAHFDYNPDVDPYIPCKEAGLAFQRGDVLHIVAQDD 280
            ||:::.|.:...:...:|..   |..:|:.:  ...||:...:                    :|
Human   403 ILRSATGMVQLVVASKENSA---EDLLRLTS--KSLPDLTSSV--------------------ED 442

  Fly   281 AYWWQARKEHERSARAGLIPSRALQERRILHDRTQKNGTDLDSKPGSCASLCTTPPGSPR----L 341
            ...|...::.|                           .|.:...|:.:|:....||:..    .
Human   443 VSSWTDNEDQE---------------------------ADGEEDEGTSSSVQRAMPGTDEPQDVC 480

  Fly   342 PASSSTSSCRQPK--TKKIMYDLTENDDFDR-EQIATYEEVAKLYPRPGVFRPIVLIGAPGVGRN 403
            .|..|..:...||  :.||......:....| |.:..|.|:            :|..|.|
Human   481 GAEESKGNLESPKQGSNKIKLKSRLSGGVHRLESVEEYNEL------------MVRNGDP----- 528

  Fly   404 ELRRRLIARDPEKFRSP--------------VPYTTRPMRTGEV--------------------- 433
            .:|...::||..|...|              |..:||.:.|.:|
Human   529 RIRMLEVSRDGRKHSLPQLLDSSSASQEYHIVKKSTRSLSTTQVESPWRLIRPSVISIIGLYKEK 593

  Fly   434 ---------AGREYIFVAREKMDADIEA----GKFVEHGEYKGHLYGTSAESVKSIVNAGCVCVL 485
                     .||:.|   |.:|...::.    |...|.|..|   .|.....|..|...|.....
Human   594 GKGLGFSIAGGRDCI---RGQMGIFVKTIFPNGSAAEDGRLK---EGDEILDVNGIPIKGLTFQE 652

  Fly   486 SPH-YQAIK------TLRTAQLKPFLIHVKPPELDILKATRTEARAKSTFDEANARS 535
            :.| ::.|:      |:||..:.|.|.....|       |.....|...|:.:...|
Human   653 AIHTFKQIRSGLFVLTVRTKLVSPSLTPCSTP-------THMSRSASPNFNTSGGAS 702

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
metro	NP_610642.2	L27	17..68	CDD:197794
		L27	75..127	CDD:197794	3/3 (100%)
		PDZ_signaling	139..229	CDD:238492	26/126 (21%)
		SH3_MPP	243..302	CDD:212796	6/58 (10%)
		Guanylate_kin	390..575	CDD:279019	38/201 (19%)
		GuKc	399..580	CDD:214504	35/192 (18%)
PDZD2	XP_005248326.1	PDZ_signaling	335..416	CDD:238492	17/80 (21%)
		PDZ_signaling	589..670	CDD:238492	16/86 (19%)
		PDZ_signaling	726..810	CDD:238492
		PDZ_signaling	2623..2694	CDD:238492
		PDZ	2785..2867	CDD:214570

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900