Protein Alignment metro and Mpp4

DIOPT Version :10

• Sequence 1: NP_610642.2
• Gene: metro / 36176
• FlyBaseID: FBgn0050021
• Length: 595
• Species: Drosophila melanogaster
• Sequence 2: NP_001158154.1
• Gene: Mpp4 / 227157
• MGIID: 2386681
• Length: 654
• Species: Mus musculus
• Alignment Length: 641
• Identity: 226/641 - (35%)
• Similarity: 340/641 - (53%)
• Gaps: 92/641 - (14%)

  Fly    13 DP--ALSKLISTLKESENLSNDQEID---FLKALLESKELNALVNVHTKVAKVGRDDRLAPVLST 72
            ||  .||.::..|.:..:|...::::   .|..||.|..|.||:.|:..:.:. ::.:|.|. :|
Mouse    41 DPENGLSGILRLLLQELSLFYSRDVNGLCLLYDLLHSPWLQALLKVYDCLQRF-KEKKLVPD-TT 103

  Fly    73 SAQVL-YEVLEQLSQHCHLNDDCKEAFHLLQDSHLQHLLFAHDAIAQKDFYPHLPEAPVEMDEDE 136
            .||:| .||||.|.: ...:.:.:|...:||..|.:.||.|||.:|||||.|.||..|..:.:.|
Mouse   104 HAQILACEVLELLPK-ASGSPEIQELRQVLQAPHCKALLSAHDTVAQKDFEPLLPPLPDNIPDSE 167

  Fly   137 ETIKIVQLVKSNEPLTGAQSTEPIVGATIKTDEESGKIIIARIMHGGAADRSGLIHVGDEVIEVN 201
            |.::||.|||:.:||          |||||..|.:|.|::||::|||..:||||::.||:::|||
Mouse   168 EAMRIVCLVKNQQPL----------GATIKRHEITGDILVARVIHGGLVERSGLLYAGDKLVEVN 222

  Fly   202 NINVEGKTPGDVLTILQNSEGTITFKLVPADNKGAQRESKVRVRAHFDYNPDVDPYIPCKEAGLA 266
            .::|||..|..|:.||..|.|||.||::|........:..|.|||..||.|..||.|||.:|||.
Mouse   223 GVSVEGLDPEQVIHILAMSCGTIMFKVIPVSAPPVSSQKMVYVRAMIDYWPQEDPDIPCMDAGLP 287

  Fly   267 FQRGDVLHIVAQDDAYWWQARKEHERSARAGLIPSRALQERRILHDRTQKNGTDLDSKPGSCASL 331
            |.:||:|.||.|:||.||||||..:.:..||||||..|.:|     :.::.......:|.:|..
Mouse   288 FLKGDILQIVDQNDALWWQARKISDLTICAGLIPSNHLLKR-----KQREFWWSQPYQPHTCLK- 346

  Fly   332 CTTPPGSPRLPASSSTSSCRQPKTKKIMYDLTENDD--FDREQI--------------------- 373
                        |:...|..:..:.||.....|.|:  |:.|::
Mouse   347 ------------STRALSMEEEDSMKIDEKCVEADEETFESEELAEAKDEFVGDGQKFFIAGFRR 399

  Fly   374 -----------------------------ATYEEVAKLYPRPG-VFRPIVLIGAPGVGRNELRRR 408
                                         |.||||.:...:|. ..|.|||:|..|||.|||||:
Mouse   400 SMRLCRRKSHFSQLHASLCCSCSCYSAVGAPYEEVVRYQRQPADKHRLIVLVGPSGVGVNELRRQ 464

  Fly   409 LIARDPEKFRSPVPYTTRPMRTGEVAGREYIFVAREKMDADIEAGKFVEHGEYKGHLYGTSAESV 473
            ||..:|..|:|.||:|||..::.|:.||||.:|:||..::.:...|.:|:|||||||||||..:|
Mouse   465 LIGCNPSCFQSAVPHTTRFPKSYEMDGREYHYVSRETFESLMYGHKMLEYGEYKGHLYGTSVNAV 529

  Fly   474 KSIVNAGCVCVLSPHYQAIKTLRTAQLKPFLIHVKPPELDILKATRTEARAKSTFDEANARSFTD 538
            .::::.|.:|::....|.|::.||..|||::|.:|||....::.:|  ..||.|.|......|.|
Mouse   530 HAVLDEGKICIMDLEPQDIQSARTRDLKPYVIFIKPPNTSSMRHSR--KNAKITTDYYVDMKFKD 592

  Fly   539 EEFEDMIKSAERIDFLYGHFFDVELVNGELVNAFEQLVQNVQRLENEPVWAPSMWV 594
            |:.::|.:.|::::..:|.|||..:||..|.:|..||:..:|:.:.|..|.|..||
Mouse   593 EDLQEMEELAQKMESQFGQFFDHVIVNDNLQDACGQLLSAIQKAQEELQWVPEAWV 648

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
metro	NP_610642.2	L27	17..68	CDD:197794	12/53 (23%)
		L27	75..127	CDD:197794	23/52 (44%)
		PDZ_MPP3-MPP4-MPP7-like	140..230	CDD:467260	42/89 (47%)
		SH3_MPP	243..302	CDD:212796	34/58 (59%)
		Guanylate_kin	390..575	CDD:395500	76/184 (41%)
Mpp4	NP_001158154.1	L27	<66..100	CDD:197794	9/34 (26%)
		L27	108..154	CDD:460717	20/46 (43%)
		PDZ_MPP3-MPP4-MPP7-like	171..251	CDD:467260	42/89 (47%)
		SH3_MPP4	264..324	CDD:212967	35/59 (59%)
		Guanylate_kin	446..636	CDD:395500	79/191 (41%)