Protein Alignment metro and magu-1

DIOPT Version :10

• Sequence 1: NP_610642.2
• Gene: metro / 36176
• FlyBaseID: FBgn0050021
• Length: 595
• Species: Drosophila melanogaster
• Sequence 2: NP_497201.1
• Gene: magu-1 / 190302
• WormBaseID: WBGene00021914
• Length: 567
• Species: Caenorhabditis elegans
• Alignment Length: 618
• Identity: 193/618 - (31%)
• Similarity: 290/618 - (46%)
• Gaps: 138/618 - (22%)

  Fly    18 KLISTLKESENLSNDQEIDFLKALLESKELNALVNVHTKVAKVGRDD-RLAPVLSTSAQVLYEVL 81
            |.:|.|:........|||.|       :||:..|          .|| .::.:.|:|.|.|.|
 Worm    42 KAVSILRNFSTNDQKQEISF-------QELSQNV----------LDDWDISNIKSSSVQQLVE-- 87

  Fly    82 EQLSQHCHLNDDCKEAFHLLQDSHLQHLLFAHDAIAQKDFYPHLPEAPVEMDEDE-ETIKIVQLV 145
                              ||....:|.:|:|...|:...|.|.||:.|.|:|||: ..:|||::|
 Worm    88 ------------------LLNLPRVQGVLWAAQEISAGRFAPQLPDVPFEVDEDDGVAVKIVRIV 134

  Fly   146 KSNEPLTGAQSTEPIVGATIKTDEESGKIIIARIMHGGAADRSGLIHVGDEVIEVNNINVEGKTP 210
            :..|||          |||||.  |.||:.:||||..|.|||||.|..||.|:|||.|.|..|.|
 Worm   135 RRGEPL----------GATIKC--ERGKVYVARIMANGVADRSGCIQEGDRVLEVNGITVADKEP 187

  Fly   211 GDVLTILQNSE-GTITFKLVPAD--NKGAQRESKVR-VRAHFDYNPDVDPYIPCKEAGLAFQRGD 271
            .:::.:|...: |.|||||:||:  .|..|::|..| .||.|||:|..|...||.||.::|:.||
 Worm   188 REIVKLLDKCDNGIITFKLIPAEINQKLKQKKSSHRYARALFDYDPWQDKRHPCPEAAISFRGGD 252

  Fly   272 VLHIVAQDDAYWWQARK----------------EHERSARAGLIPSRALQERRILHDRTQKNGTD 320
            :|.|:.:.|.||||.||                ..:.|.:.||:||..||    ......:||.|
 Worm   253 ILEILDEKDQYWWQTRKIGFGALARRKESHDDENRDDSKKVGLVPSEWLQ----CQSEIPENGID 313

  Fly   321 LDSKPGSCASLCTTPPGSPRLPASSSTSSCRQPKTKKIMYDLTENDDF----DREQIATYEEVAK 381
                                                       .:|||    :..:...||.|.:
 Worm   314 -------------------------------------------TSDDFQSFLENHKGRFYESVFR 335

  Fly   382 LYPRPGVFRPIVLIGAPGVGRNELRRRLIARDPEKFRSPVPYTTRPMRTGEVAGREYIFVAREKM 446
            ...:....|.:||:|||||||||:||:......::|.:.:|:|:||.|..|..|..|.|.:|.:|
 Worm   336 WRNKKKRRRVVVLLGAPGVGRNEIRRQFFKVFADRFTNAIPHTSRPQRPNESDGVNYYFTSRSEM 400

  Fly   447 DADIEAGKFVEHGEYKGHLYGTSAESVKSIVNAGCVCVLSPHYQAIKTLRTAQLKPFLIHVKPPE 511
            :..||..:.:|:||::.:||||:.:||:.....|.| :|:||..||:.:||.:..|.:|.|:|||
 Worm   401 ERMIERKEMLEYGEFRDNLYGTALKSVRKASEKGTV-LLTPHPLAIENIRTWEFAPIVIFVQPPE 464

  Fly   512 LDILKATRTEARAKSTFDE---------------ANARSFTDEEFEDMIKSAERIDFLYGHFFDV 561
            ....|.||...|:::|...               :.||:|:|.|...:|.::.:::..|..:.|.
 Worm   465 FGEFKHTREVYRSQTTRSHSAASSSNISQNTAATSAARAFSDVEIRQIIDNSAQMEQKYRGYCDA 529

  Fly   562 ELVNGELVNAFEQLVQNVQRLENEPVWAPSMWV 594
            .:.|.:|.....:|...:.:||::..|.|..|:
 Worm   530 IIRNVDLDTTMNELTGLIYQLESKATWMPMKWL 562

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
metro	NP_610642.2	L27	17..68	CDD:197794	12/50 (24%)
		L27	75..127	CDD:197794	12/51 (24%)
		PDZ_MPP3-MPP4-MPP7-like	140..230	CDD:467260	43/90 (48%)
		SH3_MPP	243..302	CDD:212796	28/75 (37%)
		Guanylate_kin	390..575	CDD:395500	67/199 (34%)
magu-1	NP_497201.1	PDZ_MPP3-MPP4-MPP7-like	129..208	CDD:467260	43/90 (48%)
		SH3_MPP	224..300	CDD:212796	28/75 (37%)
		Guanylate_kin	348..550	CDD:395500	66/202 (33%)