DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment metro and DLG3

DIOPT Version :9

Sequence 1:NP_610642.2 Gene:metro / 36176 FlyBaseID:FBgn0050021 Length:595 Species:Drosophila melanogaster
Sequence 2:XP_006724688.1 Gene:DLG3 / 1741 HGNCID:2902 Length:849 Species:Homo sapiens


Alignment Length:603 Identity:165/603 - (27%)
Similarity:267/603 - (44%) Gaps:105/603 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    54 HTKVAKVGRDDRLAPVLSTSAQVLYEVLEQLSQHCHLND-----DCKEAFHLLQDSHLQH--LLF 111
            :|.:..|..::.:|.:.:||..|..:|.:..|  .||||     |....|..|.|:|:.|  .|.
Human   283 NTNLQDVRHEEAVASLKNTSDMVYLKVA
KPGS--LHLNDMYAPPDYASTFTALADNHISHNSSLG 345

  Fly   112 AHDAIAQKDFYPHLPEAP------------VEMDEDEETIKIVQLVKSNEPLTGAQSTEPIVGAT 164
            ...|:..|..||..|:.|            .|.|...|..||: |.|.:   ||       :|..
Human   346 YLGAVESKVSYPAPPQVPPTRYSPIPRHMLAEEDFTREPRKII-LHKGS---TG-------LGFN 399

  Fly   165 IKTDEESGKIIIARIMHGGAADRSGLIHVGDEVIEVNNINVEGKTPGDVLTILQNSEGTITFKLV 229
            |...|:...|.::.|:.||.||.||.:..||.::.||.:|:...|.......|:.:..::|....
Human   400 IVGGEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQSVTIVAQ 464

  Fly   230 PADNKGAQRESKVR---------------------------VRAHFDYNPDVDPYIPCKEAGLAF 267
            ....:.::.|||:.                           |||.|||:...|..:|.:  ||:|
Human   465 YRPEEYSRFESKIHDLREQMMNSSMSSGSGSLRTSEKRSLYVRALFDYDRTRDSCLPSQ--GLSF 527

  Fly   268 QRGDVLHIVAQDDAYWWQAR--KEHERSARAGLIPSRALQERRILHDRTQKNGTDLDSKPG---S 327
            ..||:||::...|..|||||  ..|..|.:.|:|||:...|::   :|.:.......::.|   |
Human   528 SYGDILHVINASDDEWWQARLVTPHGESEQIGVIPSKKRVEKK---ERARLKTVKFHARTGMIES 589

  Fly   328 CASLCTTPPGSPRLPAS----------SSTSSCRQPKTKKIMYDLTENDDFDREQIATYEEVAKL 382
            ..|:.|....|.||...          :..||.::........|...:.....:.|.:||.|.:.
Human   590 NRSIKTKRKKSFRLSRKFPFYKSKENMAQESSIQEQGVTSNTSDSESSSKGQEDAILSYEPVTRQ 654

  Fly   383 ---YPRPGVFRPIVLIGAPGVGRNELRRRLIARDPEKFRSPVPYTTRPMRTGEVAGREYIF-VAR 443
               |.     ||::::|..   ::.:...||:..|.||.|.||:||||.|..||.|::|.| |:|
Human   655 EIHYA-----RPVIILGPM---KDRVNDDLISEFPHKFGSCVPHTTRPRRDNEVDGQDYHFVVSR 711

  Fly   444 EKMDADIEAGKFVEHGEYKGHLYGTSAESVKSIVNAGCVCVLSPHYQAIKTLRTAQLKPFLIHVK 508
            |:|:.||:..||:|.|::..:|||||.:||:::...|..|:|.....|||.|:.|||.|..|.:|
Human   712 EQMEKDIQDNKFIEAGQFNDNLYGTSIQSVRAVAERGKHCILDVSGNAIKRLQQAQLYPIAIFIK 776

  Fly   509 PPELDILKATRTEARAKSTFDEANARSFTDEEFEDMIKSAERIDFLYGHFFDVELVNGELVNAFE 573
            |..::.|    .|...:.|:::||          .:...|.:::..:|.:|...:....|...:.
Human   777 PKSIEAL----MEMNRRQTYEQAN----------KIYDKAMKLEQEFGEYFTAIVQGDSLEEIYN 827

  Fly   574 QLVQNVQRLENEPVWAPS 591
            ::.|.::......:|.||
Human   828 KIKQIIEDQSGHYIWVPS 845

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
metroNP_610642.2 L27 17..68 CDD:197794 2/13 (15%)
L27 75..127 CDD:197794 18/58 (31%)
PDZ_signaling 139..229 CDD:238492 25/89 (28%)
SH3_MPP 243..302 CDD:212796 26/87 (30%)
Guanylate_kin 390..575 CDD:279019 61/185 (33%)
GuKc 399..580 CDD:214504 59/181 (33%)
DLG3XP_006724688.1 MAGUK_N_PEST 52..130 CDD:402306
PDZ_signaling 131..208 CDD:238492
PDZ_signaling 224..310 CDD:238492 6/26 (23%)
PDZ_assoc 311..385 CDD:402299 21/75 (28%)
PDZ_signaling 384..462 CDD:238492 25/88 (28%)
SH3_DLG3 502..568 CDD:212962 27/67 (40%)
Guanylate_kin 658..836 CDD:395500 63/199 (32%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0194
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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