DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment metro and Card14

DIOPT Version :9

Sequence 1:	NP_610642.2	Gene:	metro / 36176	FlyBaseID:	FBgn0050021	Length:	595	Species:	Drosophila melanogaster
Sequence 2:	XP_006532429.1	Gene:	Card14 / 170720	MGIID:	2386258	Length:	1029	Species:	Mus musculus

Alignment Length:	640	Identity:	115/640 - (17%)
Similarity:	210/640 - (32%)	Gaps:	216/640 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 ALLESKELNALVNVHTKVAKVGRDD-RLAPVLSTSAQVLY-----------------EVLEQLSQ 86
            :||.|.|.....::::..::...|. |.:..:..|.|.||                 ||||...|
Mouse   446 SLLSSTESRLWWDLNSTSSREQMDSFRSSSPMPPSQQSLYKRVAEDFLEDPESLSFPEVLEMRLQ 510

  Fly    87 HCHLND-DCKEAFHLLQDSHLQH------------------LLFAHDAI------AQKDFYPHLP 126
            ...::| |....|.::..:.|..                  .|.||.::      |:|    .|.
Mouse   511 GATVDDTDTDLEFEMIDGADLSQTEDSLQGSSRSLNVSERLCLPAHSSVPVRRRPARK----ILS 571

  Fly   127 EAPVEMDEDEETIKIVQLVKSNEPLTGAQSTEPIVGATIKTDEESGKIIIARIMHGGAADRSGLI 191
            :..|...:.:..::.:.::..|  |||                    |.|.|:..|.|||...|
Mouse   572 QVTVLAFQGDALLEQIGVIGGN--LTG--------------------IFIHRVTPGSAADEMAL- 613

  Fly   192 HVGDEVIEVN--------NINVEGKTPGDVLTILQNSEGTITFKLVPADNKGAQRESKVRVRAHF 248
            ..|.:::.|:        ...:|..|....:.:|:...|:....:            |:....:.
Mouse   614 RPGTQIMMVDYKPTKPSLRATLENTTLEQAVGLLRRVNGSCYLSV------------KINTEGYK 666

  Fly   249 DYNPDVDP---------YIPCKEAGLAFQRG----------DVLHIVAQDDAY----WWQARKEH 290
            :...|:|.         ||   ...||.|||          |:||:.  |..:    .|.|...:
Mouse   667 NLIQDLDAKVVTSGDSFYI---RVNLAMQRGGDGELQTHCNDILHVT--DTMFQGRSCWHAHHVN 726

  Fly   291 E---RSARAGLIPSRALQERRIL---HDRTQKNGTDLDSKPGSCASL-------------CTTPP 336
            .   :....|.||:.:..::::|   .|.||:  ..:..|.|....|             .:.||
Mouse   727 PYTMKDMEPGTIPNYSQAQQQLLALIQDMTQR--CTVPRKVGHLVLLGHRAPFTLSTHLSLSKPP 789

  Fly   337 GSP----------RLPASSSTSSCRQPKTKKIMYDLTENDD-----FDREQIATYEEVAKLYP-R 385
            |.|          :...|..|||..|.:     :|..:.:.     |..|...|......::| |
Mouse   790 GGPQKLVRIVSVDKAAVSPLTSSFDQSQ-----WDSGKEEGGPSVCFWSESCFTLAPYTLVHPHR 849

  Fly   386 PGVFRPIVLIGAPGVGRNELRRRLIARDPEKFRSPVPYTTRPMRTGEVAGREYI----------- 439
            |...||::.:                               |...|.:.|::..
Mouse   850 PARPRPVLFV-------------------------------PRLVGRILGKKLCLLQGFKQCSAE 883

  Fly   440 FVAREKMDADIEAGKFVEHGEYKGHLYGTSAESVKSIVNAGCVCVLSPHYQAIKTLRTAQLKPFL 504
            ::::|:.....:.|..::.||..|..:..:..:|:|::|.....:|.....:::.|....:.|.:
Mouse   884 YLSQEEYATWSQRGDIIQEGESIGDHHWITRHAVESLMNMSTHALLDVRLDSVRVLHRMDMFPII 948

  Fly   505 IHVKPPELDILKATRTEARAKSTFDEANARSFTDEEFEDMIKSAE----RIDFLY 555
            |||...|....|..:...|..|          ::|:|.::.:..|    |:..||
Mouse   949 IHVSVNEKTAKKLRKGLHRLGS----------SEEQFLEVARQEEGELDRVPCLY 993

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
metro	NP_610642.2	L27	17..68	CDD:197794	6/28 (21%)
		L27	75..127	CDD:197794	18/93 (19%)
		PDZ_signaling	139..229	CDD:238492	18/97 (19%)
		SH3_MPP	243..302	CDD:212796	18/84 (21%)
		Guanylate_kin	390..575	CDD:279019	29/181 (16%)
		GuKc	399..580	CDD:214504	27/172 (16%)
Card14	XP_006532429.1	DD	19..104	CDD:387368
		Smc	<132..410	CDD:224117
		PDZ_signaling	587..659	CDD:238492	18/106 (17%)
		SH3	684..745	CDD:388381	16/65 (25%)
		NK	<884..1008	CDD:388413	24/120 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900