Protein Alignment metro and MPP7

DIOPT Version :10

• Sequence 1: NP_610642.2
• Gene: metro / 36176
• FlyBaseID: FBgn0050021
• Length: 595
• Species: Drosophila melanogaster
• Sequence 2: XP_016871230.1
• Gene: MPP7 / 143098
• HGNCID: 26542
• Length: 657
• Species: Homo sapiens
• Alignment Length: 598
• Identity: 235/598 - (39%)
• Similarity: 356/598 - (59%)
• Gaps: 50/598 - (8%)

  Fly    10 INWDPALSKLISTLKESENLSNDQEIDFLKALLESKELNALVNVHTKVAKVGRDDRLAPVLSTSA 74
            :||:   |..:|..:.|.....|..:......|..::|...: :|.|:....:...: |:|..:|
Human    95 LNWN---SLWLSEGRVSGERWADLFLHLASCQLCQRDLGVTL-IHEKLHYYEKQSPV-PILHGAA 154

  Fly    75 QVLYEVLEQLSQHCHLNDDCKEAFHLLQDSHLQHLLFAHDAIAQKDFYPHLPEAPVEMDEDEETI 139
            .:..::.|:| |:..||.:.:|...||...:::.||..||.:|||::.|.||..|.::|::|:::
Human   155 ALADDLAEEL-QNKPLNSEIRELLKLLSKPNVKALLSVHDTVAQKNYDPVLPPMPEDIDDEEDSV 218

  Fly   140 KIVQLVKSNEPLTGAQSTEPIVGATIKTDEESGKIIIARIMHGGAADRSGLIHVGDEVIEVNNIN 204
            ||::|||:.|||          |||||.||::|.||:||||.|||||||||||||||:.|||.|.
Human   219 KIIRLVKNREPL----------GATIKKDEQTGAIIVARIMRGGAADRSGLIHVGDELREVNGIP 273

  Fly   205 VEGKTPGDVLTILQNSEGTITFKLVPADNKGA-QRESKVRVRAHFDYNPDVDPYIPCKEAGLAFQ 268
            ||.|.|.:::.||..|:|.||||::|...:.. .:|.|:.::|.|||||:.|..||||||||:|:
Human   274 VEDKRPEEIIQILAQSQGAITFKIIPGSKEETPSKEGKMFIKALFDYNPNEDKAIPCKEAGLSFK 338

  Fly   269 RGDVLHIVAQDDAYWWQARKEHERSARAGLIPSRALQERRILHDRTQKNGTDLDSKPGSCASLCT 333
            :||:|.|::||||.||||:.|.:.:.|||||||:..||||:...|.:               :..
Human   339 KGDILQIMSQDDATWWQAKHEADANPRAGLIPSKHFQERRLALRRPE---------------ILV 388

  Fly   334 TPPGSPRLPASSSTS---------SCRQPKTKKIMYDLTENDDFDREQIATYEEVAKLYPRP--G 387
            .|     |..|:..|         |.:..||.|.||:..::|.:|...:.|||||.. |.|.  .
Human   389 QP-----LKVSNRKSSGFRKSFRLSRKDKKTNKSMYECKKSDQYDTADVPTYEEVTP-YRRQTNE 447

  Fly   388 VFRPIVLIGAPGVGRNELRRRLIARDPEKFRSPVPYTTRPMRTGEVAGREYIFVAREKMDADIEA 452
            .:|.:||:|..|||.|||:|:|:..|.:.:...||:|||..|:.|..|.||||:::...:.|::.
Human   448 KYRLVVLVGPVGVGLNELKRKLLISDTQHYGVTVPHTTRARRSQESDGVEYIFISKHLFETDVQN 512

  Fly   453 GKFVEHGEYKGHLYGTSAESVKSIVNAGCVCVLSPHYQAIKTLRTAQLKPFLIHVKPPELDILKA 517
            .||:|:||||.:.||||.:||:|::....||:|......:|.|||.:.||::|.:|||.::.|:.
Human   513 NKFIEYGEYKNNYYGTSIDSVRSVLAKNKVCLLDVQPHTVKHLRTLEFKPYVIFIKPPSIERLRE 577

  Fly   518 TRTEAR-AKSTFDEANARSFTDEEFEDMIKSAERIDFLYGHFFDVELVNGELVNAFEQLVQNVQR 581
            ||..|: ..|..|:..|:.||:|:|::|||||:.::..|||.||..::|.:|..||.:|.....:
Human   578 TRKNAKIISSRDDQGAAKPFTEEDFQEMIKSAQIMESQYGHLFDKIIINDDLTVAFNELKTTFDK 642

  Fly   582 LENEPVWAPSMWV 594
            ||.|..|.|..|:
Human   643 LETETHWVPVSWL 655

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
metro	NP_610642.2	L27	17..68	CDD:197794	8/50 (16%)
		L27	75..127	CDD:197794	17/51 (33%)
		PDZ_MPP3-MPP4-MPP7-like	140..230	CDD:467260	53/89 (60%)
		SH3_MPP	243..302	CDD:212796	35/58 (60%)
		Guanylate_kin	390..575	CDD:395500	78/185 (42%)
MPP7	XP_016871230.1	L27	<170..204	CDD:460717	12/33 (36%)
		PDZ_MPP3-MPP4-MPP7-like	219..299	CDD:467260	53/89 (60%)
		SH3_MPP7	313..373	CDD:212966	36/59 (61%)
		GuKc	465..644	CDD:214504	70/178 (39%)