DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment metro and Patj

DIOPT Version :9

Sequence 1:NP_610642.2 Gene:metro / 36176 FlyBaseID:FBgn0050021 Length:595 Species:Drosophila melanogaster
Sequence 2:XP_038965114.1 Gene:Patj / 140581 RGDID:1565362 Length:1858 Species:Rattus norvegicus


Alignment Length:626 Identity:129/626 - (20%)
Similarity:198/626 - (31%) Gaps:226/626 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly    35 IDFLKALLESKELNALVNVHTKVAKVG----RDDRLAPVLSTSAQVLY---EVLEQLSQHCHLND 92
            :.|....|.|:.| .|:::..|....|    ||.|    |..:.|:|.   ..|:|...|     
  Rat   145 LGFSVVALRSQSL-GLIDIFVKEVHPGSVADRDQR----LKENDQILAINDTPLDQNISH----- 199

  Fly    93 DCKEAFHLLQDS-------------HLQHLLFAHDAIAQKDFYPHLPEAPVEMDEDEETIKIVQL 144
              ::|..|||.:             |.|    :..:.:..|  ..|||. |.....|:    |:|
  Rat   200 --QQAIALLQQATGSLRLVVA
REVGHTQ----SRTSTSSAD--TTLPET-VRWGHTED----VEL 251

  Fly   145 VKSNEPLTGAQSTEPIVGATIKTDEESGKIIIARIMHGGAADRSGLIHVGDEVIEVNNINVEGKT 209
            :.....|...     |||.      :|..:::..|:.||.|||.|.:..||.::::.:.||:|.|
  Rat   252 INDGSGLGFG-----IVGG------KSSGVVVRTIVPGGLADRDGRLQTGDHILKIGSTNVQGMT 305

  Fly   210 PGDVLTILQNSEGTITFKLVPADNKG---------AQRESKVRVRAHFDYNPDVDP--------- 256
            ...|..:|:|...::.. ||..|..|         |.....:.|.|......|..|         
  Rat   306 SEQVAQVLRNCGNSVRM-LVA
RDPVGEIAVTPPTPASLPVALPVVATRTLGSDSSPFETYNVELV 369

  Fly   257 -------------YI----PCKEAGL----------AFQRGDVL---HIVAQD----DAYWWQAR 287
                         |:    |.:.:|:          |:..|.:.   .|||.|    ..:..|..
  Rat   370 KKDGQSLGIRIVGYVGTAHPGEASGIYVKSIIPGSAAYHNGQIQVNDKIVAVDGVNIQGFANQDV 434

  Fly   288 KEHERSARAGLIPSRALQERRILHDRTQKNGTDLDSKP---GSCASLCTTPPGSPRLPASSSTSS 349
            .|..|:|            .:::|....:..|.|.:.|   .|.......||..|.|..|     
  Rat   435 VEVLRNA------------GQVVHLTLVRRKTSLSASPFEQPSSREAVAEPPEVPELTGS----- 482

  Fly   350 CRQPKTKKIM--YDLTENDDFDREQIATYEEVAKLYPRPGVFRPIVLIGAPGVGRNELRRR---- 408
             .:|:|...|  .::.|..|..|:......|...:||.          ..||...|||:.|    
  Rat   483 -LKPETNSRMEAEEIGERLDNLRKDTVQALEKPDVYPE----------DIPGCPENELKSRWENL 536

  Fly   409 --------------LIARDPE--KFRSPVPYTTRPMRTGEVAGREYIFVAREKMDADIEAGKFVE 457
                          .||.|.|  |:...:|..|  :|.|              |:.|        
  Rat   537 LGPDYEVMVATLDTQIADDEELQKYSKLLPIHT--LRLG--------------MEVD-------- 577

  Fly   458 HGEYKGHLYGTSAESVKSIVNAGCVCVLSPHYQAIKTLRTAQLKPFLIHVKPPELDILKATRTEA 522
              .:.||.|      :.||...|          .:.||...|          ||.::|:....:.
  Rat   578 --SFDGHHY------ISSIAPGG----------PVDTLNLLQ----------PEDELLEVNGVQL 614

  Fly   523 RAKSTFDEAN--------------ARSFTDEEFEDMIKSAE 549
            ..||..:..:              .|.|.||...|..::.|
  Rat   615 YGKSRREAVSFLKEVPPPFTLVCCRRLFDDEASVDEPRTVE 655

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
metroNP_610642.2 L27 17..68 CDD:197794 10/36 (28%)
L27 75..127 CDD:197794 13/67 (19%)
PDZ_signaling 139..229 CDD:238492 23/89 (26%)
SH3_MPP 243..302 CDD:212796 17/101 (17%)
Guanylate_kin 390..575 CDD:279019 37/194 (19%)
GuKc 399..580 CDD:214504 36/185 (19%)
PatjXP_038965114.1 L27_2 8..65 CDD:312549
PDZ_signaling 135..218 CDD:238492 20/84 (24%)
PDZ_signaling 248..325 CDD:238492 24/92 (26%)
PDZ_signaling 366..450 CDD:238492 14/95 (15%)
CtpA <391..>511 CDD:223864 27/137 (20%)
PDZ_signaling 572..636 CDD:238492 17/113 (15%)
PDZ 684..773 CDD:214570
PDZ_signaling 1074..1165 CDD:238492
PDZ 1244..1329 CDD:214570
PDZ 1471..1578 CDD:214570
PDZ_signaling 1590..1670 CDD:238492
PDZ_signaling 1731..1816 CDD:238492
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0194
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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