DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment metro and Dlg4

DIOPT Version :9

Sequence 1:NP_610642.2 Gene:metro / 36176 FlyBaseID:FBgn0050021 Length:595 Species:Drosophila melanogaster
Sequence 2:NP_001357604.1 Gene:Dlg4 / 13385 MGIID:1277959 Length:764 Species:Mus musculus


Alignment Length:611 Identity:161/611 - (26%)
Similarity:261/611 - (42%) Gaps:166/611 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    38 LKALLESKELNALVN----VHTKVAKVGR----DDRLAPVLSTSAQVLYEVLEQLSQHCHLNDDC 94
            |:.::....:.||.|    |:.||||...    |....|.::||          .||  ||:::.
Mouse   260 LEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTS----------YSQ--HLDNEI 312

  Fly    95 KEAFHLLQD--------SHLQHLLFAHDAIAQKDFYPHLPEAPVEMDEDEETIKIVQLVKSNEPL 151
            ..:.:|..|        |..::...|.|.:.::|    :|..|             :.:..:...
Mouse   313 SHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEED----IPREP-------------RRIVIHRGS 360

  Fly   152 TGAQSTEPIVGATIKTDEESGKIIIARIMHGGAADRSGLIHVGDEVIEVNNINVEGKTPGDVLTI 216
            ||       :|..|...|:...|.|:.|:.||.||.||.:..||:::.||.:::...:.......
Mouse   361 TG-------LGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIA 418

  Fly   217 LQNSEGTITFKLVPADNKGAQRESKVR---------------------------VRAHFDYNPDV 254
            |:|:..|:|........:.::.|:|:.                           :||.|||:...
Mouse   419 LKNAGQTVTIIAQYKP
EEYSRFEAKIHDLREQLMNSSLGSGTASLRSNPKRGFYIRALFDYDKTK 483

  Fly   255 DPYIPC--KEAGLAFQRGDVLHIVAQDDAYWWQARKEHERSAR--AGLIPSRALQERRILHDRTQ 315
            |    |  ....|:|..|||||::...|..|||||:.|..|..  .|.|||:...|||       
Mouse   484 D----CGFLSQALSFHFGDVLHVIDASDEEWWQARRVHSDSETDDIGFIPSKRRVERR------- 537

  Fly   316 KNGTDLDSKPGSCASLCTTPPGSPRLPASSSTSSCRQPKTKKIMYDLTENDDFDREQIATYEEVA 380
             ..:.|.:|..                .|||.|..|:                  :.:.:||.|.
Mouse   538 -EWSRLKAKDW----------------GSSSGSQGRE------------------DSVLSYETVT 567

  Fly   381 KL---YPRPGVFRPIVLIGAPGVGRNELRRRLIARDPEKFRSPVPYTTRPMRTGEVAGREYIFV- 441
            ::   |.     |||:::|..   ::.....|::..|:||.|.||:||||.|..|:.||:|.|| 
Mouse   568 QMEVHYA-----RPIIILGPT---KDRANDDLLSEFPDKFGSCVPHTTRPKREYEIDGRDYHFVS 624

  Fly   442 AREKMDADIEAGKFVEHGEYKGHLYGTSAESVKSIVNAGCVCVLSPHYQAIKTLRTAQLKPFLIH 506
            :||||:.||:|.||:|.|:|..||||||.:||:.:...|..|:|.....|::.|:.|.|.|..|.
Mouse   625 SREKMEKDIQAHKFIEAGQYNSHLYGTSVQSVREVAEQGKHCILDVSANAVRRLQAAHLHPIAIF 689

  Fly   507 VKPPELD-ILKATR--TEARAKSTFDEANARSFTDEEFEDMIKSAERIDFLYGHFFDVELVNGEL 568
            ::|..|: :|:..:  ||.:|:..||.|..   .::||.:...:               :|.|: 
Mouse   690 IRPRSLENVLEINKRITEEQARKAFDRATK---LEQEFTECFSA---------------IVEGD- 735

  Fly   569 VNAFEQLVQNVQRLENEPVWAPSMWV 594
              :||::...|:|: .|.:..|.:||
Mouse   736 --SFEEIYHKVKRV-IEDLSGPYIWV 758

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
metroNP_610642.2 L27 17..68 CDD:197794 10/37 (27%)
L27 75..127 CDD:197794 10/59 (17%)
PDZ_signaling 139..229 CDD:238492 22/89 (25%)
SH3_MPP 243..302 CDD:212796 25/89 (28%)
Guanylate_kin 390..575 CDD:279019 66/188 (35%)
GuKc 399..580 CDD:214504 62/184 (34%)
Dlg4NP_001357604.1 L27 <26..47 CDD:351851
MAGUK_N_PEST 54..104 CDD:337803
PDZ 105..189 CDD:334167
PDZ 197..287 CDD:214570 9/26 (35%)
PDZ_assoc 285..352 CDD:313755 17/95 (18%)
PDZ 350..434 CDD:214570 23/103 (22%)
SH3_DLG4 470..535 CDD:212963 26/68 (38%)
Guanylate_kin 573..751 CDD:279019 70/207 (34%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0194
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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