DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment metro and Dlg1

DIOPT Version :9

Sequence 1:	NP_610642.2	Gene:	metro / 36176	FlyBaseID:	FBgn0050021	Length:	595	Species:	Drosophila melanogaster
Sequence 2:	XP_006521824.1	Gene:	Dlg1 / 13383	MGIID:	107231	Length:	939	Species:	Mus musculus

Alignment Length:	714	Identity:	184/714 - (25%)
Similarity:	299/714 - (41%)	Gaps:	184/714 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 VMASDINWDPALSKLISTLKESENLSN---------DQEIDFLKALLESKELNALV-----NVH- 54
            |..:|:. |...||.:..|||:.::..         .::|..:|.:...|.|...:     |.|
Mouse   279 VNEADVR-DVTHSKAVEALKEAGSIVRLYVKRRKPASEKIMEIKLIKGPKGLGFSIAGGVGNQHI 342

  Fly    55 --------TKVAKVG---RDDRLA---PVLSTSAQVLYEV--------LEQLSQHCHL------- 90
                    ||:.:.|   :|.:|.   .:|:.::..|.||        |:..|...:|
Mouse   343 PGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNSVCLEEVTHEEAVTALKNTSDFVYLKVAKPTS 407

  Fly    91 ---ND-----DCKEAFHLLQDSHLQHLLFAHDAIAQKDFYP--HLPEAPVEMDEDE---ETIKIV 142
               ||     |...:.....|:|:.    ....:.|....|  :.|.:...:.:||   |..|:|
Mouse   408 MYINDGYAPPDITNSSSQSVDNHVS----PSSCLGQTPTSPARYSPISKAVLGDDEITREPRKVV 468

  Fly   143 QLVKSNEPLTGAQSTEPIVGATIKTDEESGKIIIARIMHGGAADRSGLIHVGDEVIEVNNINVEG 207
                .:...||       :|..|...|:...|.|:.|:.||.||.||.:..||.:|.||::::..
Mouse   469 ----LHRGSTG-------LGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRA 522

  Fly   208 KTPGDVLTILQNSEGTITF--KLVP----------------------ADNKGAQRESKVR---VR 245
            .:.......|:|:...:|.  :..|                      :...|:.|.|:.|   ||
Mouse   523 ASHEQAAAALKNAGQAVTIVAQYRPEEYSRFEAKIHDLREQMMNSSVSSGSGSLRTSQKRSLYVR 587

  Fly   246 AHFDYNPDVDPYIPCKEAGLAFQRGDVLHIVAQDDAYWWQARK--EHERSARAGLIPSRALQERR 308
            |.|||:...|..:|.:  ||.|:.||:||::...|..|||||:  ....|...|:|||:...|::
Mouse   588 ALFDYDKTKDSGLPSQ--GLNFRFGDILHVINASDDEWWQARQVTPDGESDEVGVIPSKRRVEKK 650

  Fly   309 --------------------ILHDRTQKN----------GTDLDSKPGSCASLCTTPPGSPRLPA 343
                                ..:|:.:||          ..|...:..|.|....|.      .|
Mouse   651 ERARLKTVKFNSKTRGDKGQSFNDKRKKNLFSRKFPFYKNKDQSEQETSDADQHVTS------NA 709

  Fly   344 SSSTSSCRQPKTKKIMYDLTENDDF------DREQIATYEEVAKLYPRPGVFRPIVLIGAPGVGR 402
            |.|.||          |.:...|::      ..|.:.:||.|.:  ......||::::|..   :
Mouse   710 SDSESS----------YLILITDEYGCSKGGQEEYVLSYEPVNQ--QEVNYTRPVIILGPM---K 759

  Fly   403 NELRRRLIARDPEKFRSPVPYTTRPMRTGEVAGREYIFV-AREKMDADIEAGKFVEHGEYKGHLY 466
            :.:...||:..|:||.|.||:||||.|..||.||:|.|| :||:|:.||:..||:|.|:|..|||
Mouse   760 DRVNDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKFIEAGQYNNHLY 824

  Fly   467 GTSAESVKSIVNAGCVCVLSPHYQAIKTLRTAQLKPFLIHVKPPELD-ILKATR--TEARAKSTF 528
            |||.:||:::...|..|:|.....|||.|:.|||.|..|.:||..:: |::..:  ||.:|:.||
Mouse   825 GTSVQSVRAVAEKGKHCILDVSGNAIKRLQIAQLYPISIFIKPKSMENIMEMNKRLTEEQARKTF 889

  Fly   529 DEANARSFTDEEFEDMIKSAERIDFLYGHFFDVELVNGE-LVNAFEQLVQNVQRLENEPVWAPS 591
            :.|..   .::||.:             ||  ..:|.|: |.:.:.|:.|.::......:|.|:
Mouse   890 ERAMK---LEQEFTE-------------HF--TAIVQGDTLEDIYNQVKQIIEEQSGPYIWVPA 935

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
metro	NP_610642.2	L27	17..68	CDD:197794	16/79 (20%)
		L27	75..127	CDD:197794	13/76 (17%)
		PDZ_signaling	139..229	CDD:238492	24/91 (26%)
		SH3_MPP	243..302	CDD:212796	26/63 (41%)
		Guanylate_kin	390..575	CDD:279019	69/189 (37%)
		GuKc	399..580	CDD:214504	68/185 (37%)
Dlg1	XP_006521824.1	L27_1	2..62	CDD:370268
		MAGUK_N_PEST	106..223	CDD:371162
		PDZ_signaling	224..308	CDD:238492	8/29 (28%)
		PDZ_signaling	317..403	CDD:238492	18/85 (21%)
		PDZ_assoc	404..465	CDD:371157	11/64 (17%)
		PDZ	463..547	CDD:214570	25/94 (27%)
		SH3_DLG1	582..648	CDD:212964	27/67 (40%)
		Guanylate_kin	748..926	CDD:366206	71/198 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810