DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment metro and Patj

DIOPT Version :9

Sequence 1:	NP_610642.2	Gene:	metro / 36176	FlyBaseID:	FBgn0050021	Length:	595	Species:	Drosophila melanogaster
Sequence 2:	NP_766284.2	Gene:	Patj / 12695	MGIID:	1277960	Length:	1834	Species:	Mus musculus

Alignment Length:	668	Identity:	121/668 - (18%)
Similarity:	203/668 - (30%)	Gaps:	271/668 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LEAVMASDINWD---PALSKLISTLKESENLSNDQEIDFLK-------ALLESKELNALVNVHTK 56
            |..|:|.::...   .:.|...:||.|:....:.:|::.:.       .::..|....:|.....
Mouse   213 LRLVVAREVGHTQGRASTSSADTTLPETVCWGHTEEVELINDGSGLGFGIVGGKSSGVVVRTIVP 277

  Fly    57 VAKVGRD------DRLAPVLSTSAQ-VLYEVLEQLSQHCHLNDDCKEAFHLLQDSHLQHLLFAHD 114
            .....||      |.:..:..|:.| :..|.:.|:.::|               .:...:|.|.|
Mouse   278 GGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLRNC---------------GNSVRMLVARD 327

  Fly   115 AIAQKDFYPHLP-EAPV--------EMDEDEETIKI--VQLVKSNEPLTGAQSTEPIVG--ATIK 166
            .:.:....|..| ..||        .:|.|....:.  |:|||.:....|.:    |||  .|..
Mouse   328 PVGEIAVTPPTPVSLPVALPAVATRTLDSDRSPFETYSVELVKKDGQSLGIR----IVGYVGTAH 388

  Fly   167 TDEESGKIIIARIMHGGAADRSGLIHVGDEVIEVNNINVEGKTPGDVLTILQNSEGTITFKLVPA 231
            ..|.|| |.:..|:.|.||..:|.|.|.|:::.|:.:|::|....||:.:|:|:...:...||
Mouse   389 PGEASG-IYVKSIIPGSAAYHNGQIQVNDKIVAVDGVNIQGFANQDVVEVLRNAGQVVHLTLV-- 450

  Fly   232 DNKGAQRESKVRVRAHFDYNPDVDPYIPCKEAGLAFQRGDVLHIVAQDDAYWWQARKEHERS--- 293
                 :|::.:          ...|:                               ||..|
Mouse   451 -----RRKTSL----------SASPF-------------------------------EHSSSRET 469

  Fly   294 -ARAGLIPSRALQERRILHDRTQKNGTDLDSKPGSCASLCTTPPGSPRLPASSSTSSCRQPKTKK 357
             |....:|.||                                 |||:..|:.|..:
Mouse   470 VAEPPKVPERA---------------------------------GSPKPEANLSVEA-------- 493

  Fly   358 IMYDLTENDDFDREQIATYEEVAKLYPRPGVFRPIVLIGAPGVGRNELRRR-------------- 408
              .::.|..|..:.......|...:||..          .||...|||:.|
Mouse   494 --EEIGERLDNLKNNTVQALEKPDVYPEK----------VPGSPENELKSRWENLLGPDYEVMVA 546

  Fly   409 ----LIARDPE--KFRSPVPYTTRPMRTGEVAGREYIFVAREKMDADIEAGKFVEHGEYKGHLYG 467
                .||.|.|  |:...:|..|  :|.|              |:.|          .:.||.|
Mouse   547 TLDAQIADDEELQKYSKLLPIHT--LRLG--------------MEVD----------SFDGHHY- 584

  Fly   468 TSAESVKSIVNAGCVCVLSPHYQAIKTLRTAQLKPFLIHVKPPELDILKATRTEARAKSTFDEAN 532
                 :.|:...|          .:.||...|          ||.::|:....:...||..:..:
Mouse   585 -----ISSVAPGG----------PVDTLNLLQ----------PEDELLEVNGMQLYGKSRREAVS 624

  Fly   533 --------------ARSFTDEEFEDMIKSAE------RIDFLYGHFFDVELV---NGELVNAFEQ 574
                          .|.|.||...|..::.|      .:|    |..||.:.   :|||.
Mouse   625 FLKEVPPPFTLVCCRRLFDDEASVDEPRTMEPALLEAEVD----HSVDVNIEDDDDGELA----- 680

  Fly   575 LVQNVQRLENEPVWAPSM 592
                        :|:|.:
Mouse   681 ------------LWSPEV 686

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
metro	NP_610642.2	L27	17..68	CDD:197794	10/63 (16%)
		L27	75..127	CDD:197794	9/53 (17%)
		PDZ_signaling	139..229	CDD:238492	28/93 (30%)
		SH3_MPP	243..302	CDD:212796	6/62 (10%)
		Guanylate_kin	390..575	CDD:279019	43/227 (19%)
		GuKc	399..580	CDD:214504	42/223 (19%)
Patj	NP_766284.2	L27_2	8..65	CDD:312549
		PDZ_signaling	135..218	CDD:238492	2/4 (50%)
		PDZ_signaling	248..325	CDD:238492	12/91 (13%)
		PDZ_signaling	363..450	CDD:238492	28/91 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	456..488		11/105 (10%)
		PDZ_signaling	572..636	CDD:238492	16/113 (14%)
		PDZ	685..774	CDD:214570	0/2 (0%)
		PDZ_signaling	1072..1163	CDD:238492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1171..1219
		PDZ	1242..1327	CDD:214570
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1340..1453
		MPDZ_u10	<1453..1468	CDD:374710
		PDZ	1469..1554	CDD:214570
		PDZ_signaling	1566..1646	CDD:238492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1657..1676
		PDZ_signaling	1707..1792	CDD:238492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1811..1834
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810