DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment metro and Cask

DIOPT Version :10

Sequence 1:NP_610642.2 Gene:metro / 36176 FlyBaseID:FBgn0050021 Length:595 Species:Drosophila melanogaster
Sequence 2:XP_011245733.1 Gene:Cask / 12361 MGIID:1309489 Length:972 Species:Mus musculus


Alignment Length:698 Identity:199/698 - (28%)
Similarity:329/698 - (47%) Gaps:174/698 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 DINWDP----------ALSKLISTLKESENLS--NDQEIDFLKALLESKELNALVNVHTKV-AKV 60
            |.:.||          |:|:::.:|:|...|:  :::::|||.::.:.:.|:.|::::.|: .|.
Mouse   336 DFSEDPTSSGLLAAERAVSQVLDSLEEIHALTDCSEKDLDFLHSVFQDQHLHTLLDLYDKINTKS 400

  Fly    61 GRDDRLAPVLSTSAQVLYEVLEQLSQHCH-LNDDCKEAFHLLQDSHLQHLLFAHDAIAQKDF--- 121
            ....|..|  |.:.|...||||::|  |: .|:|.||...:|...|...||..||.:|.:.:   
Mouse   401 SPQIRNPP--SDAVQRAKEVLEEIS--CYPENNDAKELKRILTQPHFMALLQTHDVVAHEVYSDE 461

  Fly   122 ---------YPHL----PE-APVEMDEDEET-IKIVQLVKSNEPLTGAQSTEPIVGATIKTDEES 171
                     .|:|    || |..:||.:..| :::||..|:.:        || :|.|:|.: |.
Mouse   462 ALRVTPPPTSPYLNGDSPESANGDMDMENVTRVRLVQFQKNTD--------EP-MGITLKMN-EL 516

  Fly   172 GKIIIARIMHGGAADRSGLIHVGDEVIEVNNINVEGKTPGDVLTILQNSEGTITFKLVPA----- 231
            ...|:|||||||...|.|.:|||||:.|:|.|:|..:|...:..:|:...|:||||:||:     
Mouse   517 NHCIVARIMHGGMIHRQGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITFKIVPSYRTQS 581

  Fly   232 -----DNKGAQRES------------------------KVRVRAHFDYNPDVDPYIPCKEAGLAF 267
                 |:....|:|                        ::.|||.|:|:|..|..|||||||:.|
Mouse   582 SSCERDSPSTSRQSPANGHSSTNNSVSDLPSTTQPKGRQIYVRAQFEYDPAKDDLIPCKEAGIRF 646

  Fly   268 QRGDVLHIVAQDDAYWWQARKEHERSARAGLIPSRALQERRILHDRTQKNGTDLDSKPGSCASLC 332
            :.||::.|:::||..|||.:.|:.::..||||||..|||.|:                 :|.::.
Mouse   647 RVGDIIQIISKDDHNWWQGKLENSKNGTAGLIPSPELQEWRV-----------------ACIAME 694

  Fly   333 TTPPGSPRLPASSSTSSC----RQPKTKKIMYDLTENDDFDREQIATYEEVAKL--YPRPGVFRP 391
            .|        .....:||    ::.|..|..|....|..||:..:.|||||.||  :.|    :.
Mouse   695 KT--------KQEQQASCTWFGKKKKQYKDKYLAKHNAVFDQLDLVTYEEVVKLPAFKR----KT 747

  Fly   392 IVLIGAPGVGRNELRRRLIARDPEKFRSPVPYTTRPMRTGEVAGREYIFVAREKMDADIEAGKFV 456
            :||:||.||||..::..||.:.|::|..|:|:||||.:..|..|:.|.||:.::|..||...:::
Mouse   748 LVLLGAHGVGRRHIKNTLITKHPDRFAYPIPHTTRPPKKDEENGKNYYFVSHDQMMQDISNNEYL 812

  Fly   457 EHGEYKGHLYGTSAESVKSIVNAGCVCVLS--------------------------------PHY 489
            |:|.::..:|||..|:::.|...|.:.:|.                                ||:
Mouse   813 EYGSHEDAMYGTKLETIRKIHEQGLIAILDVEPQGLEKSSGQGWLEAKSQSWSWSSTSSPWVPHW 877

  Fly   490 Q--------AIKTLRTAQLKPFLIHVKPPELDILKATRTEARAKSTFDEANARSFTDEEFEDMIK 546
            .        |:|.||||:..||::.:..|.:            ....:|       ||..:.:.|
Mouse   878 SSPERRFLLALKVLRTAEFAPFVVFIAAPTI------------TPGLNE-------DESLQRLQK 923

  Fly   547 SAERIDFLYGHFFDVELVNGELVNAFEQLVQNVQRLENEPVWAPSMWV 594
            .::.:...|.|:||:.::|.|:......|.:.|:.:...|.|.|..||
Mouse   924 ESDVLQRTYAHYFDLTIINNEIDETIRHLEEAVELVCTAPQWVPVSWV 971

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
metroNP_610642.2 L27 17..68 CDD:197794 12/53 (23%)
L27 75..127 CDD:197794 20/68 (29%)
PDZ_MPP3-MPP4-MPP7-like 140..230 CDD:467260 35/89 (39%)
SH3_MPP 243..302 CDD:212796 29/58 (50%)
Guanylate_kin 390..575 CDD:395500 56/224 (25%)
CaskXP_011245733.1 STKc_CASK 8..313 CDD:270996
L27 354..407 CDD:197794 12/52 (23%)
L27 412..462 CDD:460717 18/51 (35%)
PDZ_CASK-like 495..575 CDD:467267 35/89 (39%)
SH3_CASK 622..683 CDD:213014 30/60 (50%)
Guanylate_kin 744..957 CDD:395500 58/235 (25%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.