DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment metro and dlg1a

DIOPT Version :9

Sequence 1:	NP_610642.2	Gene:	metro / 36176	FlyBaseID:	FBgn0050021	Length:	595	Species:	Drosophila melanogaster
Sequence 2:	XP_005165955.1	Gene:	dlg1a / 114446	ZFINID:	ZDB-GENE-010724-8	Length:	935	Species:	Danio rerio

Alignment Length:	630	Identity:	168/630 - (26%)
Similarity:	262/630 - (41%)	Gaps:	162/630 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 LKALLESKELNALVN----VHTKVAK---VGRDDRLAPVLSTSAQVLYEVLEQLSQHCHLNDDCK 95
            |:.:.....:.||.|    |:.||||   |..:|..||.         :|....|||..
Zfish   386 LEEVTHEDAVAALKNTPDVVYLKVAKPTSVFMNDSYAPP---------DVTSSYSQHME------ 435

  Fly    96 EAFHLLQDSHLQHLLFAHDAIAQKDFYPHLPE--APVE--MDEDEETIKIVQLVKSNEPLTGAQS 156
              .|:...|:|...|           .|..|.  :||.  |..|:|..:..:.:..:...||
Zfish   436 --NHISTQSYLSQPL-----------TPATPSRYSPVSKGMLGDDEITREPRKIVLHRGTTG--- 484

  Fly   157 TEPIVGATIKTDEESGKIIIARIMHGGAADRSGLIHVGDEVIEVNNINVEGKTPGDVLTILQNSE 221
                :|..|...|:...|.|:.|:.||.||..|.:..||.::.||.:::...|.......|:|:.
Zfish   485 ----LGFNIVGGEDGEGIFISFILAGGPADLCGELRKGDRIVSVNGVDLRSATHEQAAAALKNAG 545

  Fly   222 GTITF--KLVP----------------------ADNKGAQRESKVR---VRAHFDYNPDVDPYIP 259
            .|:|.  :..|                      :...|:.|.|:.|   |||.|||:...|..:|
Zfish   546 QTVTIIAQYRPEEYSRFEAKIHDLREQMMNSSISSGSGSLRTSQKRTLYVRALFDYDITKDSGLP 610

  Fly   260 CKEAGLAFQRGDVLHIVAQDDAYWWQARK-----EHERSARAGLIPSRALQERRILHDRTQKNGT 319
            .:  ||.|:.||:||::...|..|||||.     |.|   ..|:|||:...||:   :|.:....
Zfish   611 SQ--GLNFRFGDILHVLNASDEEWWQARHVTTDGEME---EMGVIPSKKRVERK---ERARLKTV 667

  Fly   320 DLDSKPGSCASLCTTPPGSPRLPASSSTSSCRQPKTKKIMY----------DLTENDDFDREQ-- 372
            ..:||                   |...:.....|.:|.::          |..|.:..|.:|
Zfish   668 KFNSK-------------------SRDKAQSLNDKRRKTLFSRKFLFSKNKDTGEQETSDVDQHV 713

  Fly   373 -----------------IATYEEVAKLYPRPGVFRPIVLIGAPGVGRNELRRRLIARDPEKFRSP 420
                             :.:||.|.:  ......||::::|..   ::.:...||:..|:||.|.
Zfish   714 TSNASDSESSFRGQEDYVLSYETVTQ--QEVSYSRPVIILGPM---KDRINDDLISEFPDKFGSC 773

  Fly   421 VPYTTRPMRTGEVAGREYIFV-AREKMDADIEAGKFVEHGEYKGHLYGTSAESVKSIVNAGCVCV 484
            ||:||||.|..||.||:|.|| :||:|:.||:..||:|.|:|..||||||.:||:.:...|..|:
Zfish   774 VPHTTRPKRDYEVDGRDYHFVNSREQMEKDIQDHKFIEAGQYNNHLYGTSVQSVREVAEKGKHCI 838

  Fly   485 LSPHYQAIKTLRTAQLKPFLIHVKPPELD-ILKATR--TEARAKSTFDEANARSFTDEEFEDMIK 546
            |.....|||.|:.|||.|..:.:||..:: ||:..:  .|.:.:.|:|.|..   .::||.:
Zfish   839 LDVSGNAIKRLQLAQLYPIAVFIKPKSVENILEMNKRLMEEQGRKTYDRAMK---LEQEFLE--- 897

  Fly   547 SAERIDFLYGHFFDVELVNGE-LVNAFEQLVQNVQRLENEPVWAP 590
                      ||  ..:|.|: |...:.|:.|.::......:|.|
Zfish   898 ----------HF--TAIVQGDTLEEIYNQVKQIIEEQSGPFIWVP 930

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
metro	NP_610642.2	L27	17..68	CDD:197794	11/36 (31%)
		L27	75..127	CDD:197794	9/51 (18%)
		PDZ_signaling	139..229	CDD:238492	22/91 (24%)
		SH3_MPP	243..302	CDD:212796	27/66 (41%)
		Guanylate_kin	390..575	CDD:279019	67/189 (35%)
		GuKc	399..580	CDD:214504	66/185 (36%)
dlg1a	XP_005165955.1	L27_1	4..62	CDD:286187
		MAGUK_N_PEST	109..230	CDD:287565
		PDZ_signaling	231..315	CDD:238492
		PDZ_signaling	324..410	CDD:238492	6/23 (26%)
		PDZ_assoc	411..474	CDD:287558	20/90 (22%)
		PDZ	472..556	CDD:214570	22/90 (24%)
		SH3	588..661	CDD:302595	31/80 (39%)
		Guanylate_kin	744..922	CDD:279019	69/198 (35%)
		GuKc	755..922	CDD:214504	66/184 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810