DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment metro and Card10

DIOPT Version :9

Sequence 1:	NP_610642.2	Gene:	metro / 36176	FlyBaseID:	FBgn0050021	Length:	595	Species:	Drosophila melanogaster
Sequence 2:	XP_036014949.1	Gene:	Card10 / 105844	MGIID:	2146012	Length:	1144	Species:	Mus musculus

Alignment Length:	418	Identity:	80/418 - (19%)
Similarity:	136/418 - (32%)	Gaps:	133/418 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   149 EPLTGAQSTEPIVGATIKTDEESGKIIIARIMHGGAADRSGLIHVGDEVIEVNNINVEG------ 207
            :|...:..:.|.:|     |..|| .::.|::.|..:.|:          |......||
Mouse   726 DPQDKSPDSMPGLG-----DRWSG-AVVRRVLSGPGSART----------EQKEPRAEGTGLEGA 774

  Fly   208 --KTPGDVLTILQNSEGTITFKL-----------VPADNKGAQRESKVRVRAHFDYNPDVDPYIP 259
              :......|:..|...|:.|.|           :.|..||...| ...:||:|......||:..
Mouse   775 GLEAEAQQRTLPWNQSSTLPFLLDSKACHSFHEALDAWAKGPGAE-PFYIRANFSLPERSDPHAL 838

  Fly   260 CKEAGLAFQRGDVLHIVAQDDAYWWQARKE--HERSARAGLIPS--RA-----LQERRILHDRTQ 315
            |.:|....:..|..|...|:   |:..|.:  ..|....|.:|:  ||     :||:.::..|.:
Mouse   839 CVKAQEILRLVDPAHKRRQE---WFCTRVDTLTLRDLDRGTVPNYQRAQQLLEVQEKYLISSRHR 900

  Fly   316 KNGTDLDS--------KPGSCASLCTTPPGSPRLPASSSTSSCRQPKTKKIMYDLTENDDFDREQ 372
            ...::|..        ||..    .|....:.:|||                           |.
Mouse   901 SPRSNLKKRALGLVRPKPAG----GTAGDSAEQLPA---------------------------EP 934

  Fly   373 IATYEEVAKLYP--RP---GVFRPIVLIG---APGVGRNELRRRLIARDPEKFRSPVPYTTRPMR 429
            .:..|...|.|.  ||   ...||:||:.   ||.:.||.|         :...|.:.:...|..
Mouse   935 CSELERSLKPYSLVRPLLVSALRPVVLLPECLAPRLIRNLL---------DLPSSRLDFQVCPAE 990

  Fly   430 --------TGEVAGREYIFVAREKMDADIEAGKFVEHGEYKGHLYGTSAESVKSIVNAGCVCVLS 486
                    |....|....:.|...:.:.|.|   ::....|.|                  |:|.
Mouse   991 SLSGEEQCTSSAPGAPKAWPATAGLGSRIRA---IQESVGKKH------------------CLLE 1034

  Fly   487 PHYQAIKTLRTAQLKPFLIHVKPPELDI 514
            ...:.::.|..:::.|.:|||:..|.::
Mouse  1035 LGARGVRELVHSEVYPIVIHVEVTEKNV 1062

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
metro	NP_610642.2	L27	17..68	CDD:197794
		L27	75..127	CDD:197794
		PDZ_signaling	139..229	CDD:238492	17/98 (17%)
		SH3_MPP	243..302	CDD:212796	15/62 (24%)
		Guanylate_kin	390..575	CDD:279019	26/136 (19%)
		GuKc	399..580	CDD:214504	20/124 (16%)
Card10	XP_036014949.1	CARD_CARD10_CARMA3	150..235	CDD:260069
		Smc	<270..>573	CDD:224117
		SH3	822..884	CDD:418401	16/64 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900