DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment metro and mpp7b

DIOPT Version :9

Sequence 1:	NP_610642.2	Gene:	metro / 36176	FlyBaseID:	FBgn0050021	Length:	595	Species:	Drosophila melanogaster
Sequence 2:	XP_021324128.1	Gene:	mpp7b / 101882129	ZFINID:	ZDB-GENE-141212-293	Length:	298	Species:	Danio rerio

Alignment Length:	267	Identity:	131/267 - (49%)
Similarity:	174/267 - (65%)	Gaps:	16/267 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 VHTKVAKVGRDDRLAPVLSTSAQVLYEVLEQLSQHCHLNDDCKEAFHLLQDSHLQHLLFAHDAIA 117
            |:.::.|. |..|.||:|.::..:.:.:.|:|....: :.:..|..:||...|:|.||..||.:|
Zfish    10 VYDRLQKY-RAQRPAPLLDSTQGLAHRLAEELQDTVN-SPETTELLNLLSKPHVQTLLLVHDVVA 72

  Fly   118 QKDFYPHLPEAPVEMD---EDEETIKIVQLVKSNEPLTGAQSTEPIVGATIKTDEESGKIIIARI 179
            ||.|.|.||..|...|   |||::||||.|||:.|||          |||||.||.||.||:||:
Zfish    73 QKRFDPRLPPLPPLPDCNEEDEDSIKIVCLVKNQEPL----------GATIKRDESSGAIIVARV 127

  Fly   180 MHGGAADRSGLIHVGDEVIEVNNINVEGKTPGDVLTILQNSEGTITFKLVPADNKGAQ-RESKVR 243
            |.|||||||||||.||.:.|||.:.||.|...:::.||..|||.:|||:||..|:..: .:::|.
Zfish   128 MRGGAADRSGLIHEGDMLKEVNGVPVEDKNLQEIIPILAKSEGAVTFKVVPGTNEELETNDTQVF 192

  Fly   244 VRAHFDYNPDVDPYIPCKEAGLAFQRGDVLHIVAQDDAYWWQARKEHERSARAGLIPSRALQERR 308
            |||.|||:|..||.|||::|||.|||||||.||:|||..|||||:..:.:.||||||||.|||||
Zfish   193 VRALFDYDPQADPAIPCRDAGLEFQRGDVLQIVSQDDDTWWQARRHGDANLRAGLIPSRQLQERR 257

  Fly   309 ILHDRTQ 315
            ::..|.:
Zfish   258 VMLQRPE 264

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
metro	NP_610642.2	L27	17..68	CDD:197794	4/14 (29%)
		L27	75..127	CDD:197794	17/51 (33%)
		PDZ_signaling	139..229	CDD:238492	51/89 (57%)
		SH3_MPP	243..302	CDD:212796	38/58 (66%)
		Guanylate_kin	390..575	CDD:279019
		GuKc	399..580	CDD:214504
mpp7b	XP_021324128.1	L27	31..74	CDD:308467	12/43 (28%)
		PDZ	97..179	CDD:214570	52/91 (57%)
		SH3_MPP	192..252	CDD:212796	39/59 (66%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	94	1.000	Domainoid score	I7412
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D245552at33208
OrthoFinder	1	1.000	-	-		FOG0000824
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.920