DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment metro and mpp4

DIOPT Version :9

Sequence 1:	NP_610642.2	Gene:	metro / 36176	FlyBaseID:	FBgn0050021	Length:	595	Species:	Drosophila melanogaster
Sequence 2:	XP_031749716.1	Gene:	mpp4 / 100495166	XenbaseID:	XB-GENE-988529	Length:	684	Species:	Xenopus tropicalis

Alignment Length:	669	Identity:	232/669 - (34%)
Similarity:	357/669 - (53%)	Gaps:	107/669 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LSKLISTLKESENLSNDQEID---FLKALLESKELNALVNVHTKVAKVGRDDRLAPVLSTSAQVL 77
            ||::::.:.|...|...|:::   .|..||::..|.:|:.||:.:.:. ...|..|||..:..:.
Frog    29 LSQVLTMVLEELGLYYHQDVNGIGVLYNLLQAPWLQSLLKVHSCLQQY-IQQRPQPVLPKACILS 92

  Fly    78 YEVLEQLSQHCHLNDDCKEAFHLLQDSHLQHLLFAHDAIAQKDFYPHLPEAPVEMDEDEETIKIV 142
            .||:..|.:... :.|.:|...|||..|.:.||.|||.:||.||.|.||..|..:.::||.::||
Frog    93 NEVVGVLRETTS-SADLRELKRLLQGPHFKALLSAHDMVAQADFEPVLPPLPDNIPDNEEAMRIV 156

  Fly   143 QLVKSNEPLTGAQSTEPIVGATIKTDEESGKIIIARIMHGGAADRSGLIHVGDEVIEVNNINVEG 207
            .|||:.:||          |||||..|.:|.||:||::|||.||||||::.||:::|||.:.|:|
Frog   157 CLVKNKQPL----------GATIKRHEITGDIIVARVIHGGLADRSGLLYAGDKLVEVNGVLVDG 211

  Fly   208 KTPGDVLTILQNSEGTITFKLVPADNKGAQRESKVRVRAHFDYNPDVDPYIPCKEAGLAFQRGDV 272
            ..|..|:.||..|||||.|||.|.:::.....:.:.|||..||.|..||.|||.:|||.||||::
Frog   212 LEPEQVIQILARSEGTIVFKLSPVNDRYISSHTMLYVRAMADYWPQQDPAIPCADAGLPFQRGEI 276

  Fly   273 LHIVAQDDAYWWQARKEHERSARAGLIPSRALQERR----------ILHD--------------- 312
            |.||.|:|:.||||||..:....||||||..|.:|:          :.|.
Frog   277 LQIVDQNDSLWWQARKASDLGRCAGLIPSNHLLKRKQREFWWSQPFMSHSCIKASQLSTIGEEED 341

  Fly   313 -RTQKNGTDLDS--------KPGS--CASLCTTPPGSPRL--------PASSSTSSCRQPK--TK 356
             :.::...:.|.        |.|:  |...|:....|..|        |...:| ...||:  ..
Frog   342 MKIEEKFVEADEETFESEELKGGNVICKFFCSVHRNSNHLVQDIYISMPQDLAT-IWMQPQRHNY 405

  Fly   357 KIMYDLTENDDFDREQ--------------------------------------IATYEEVAKLY 383
            ::.|...|.:|..|::                                      .|.||||.:..
Frog   406 RLEYFGQEKEDEFRDKDGNIIAGFRRSMRLCRRKTLINHMSCYSRCPSNCYHTVAAPYEEVVRYQ 470

  Fly   384 PRP-GVFRPIVLIGAPGVGRNELRRRLIARDPEKFRSPVPYTTRPMRTGEVAGREYIFVAREKMD 447
            .|| ...|.|||:|..|||.||:|::||..:|..|:||||:|||..:|.|..||||.||::|..:
Frog   471 RRPCDRHRLIVLLGPSGVGVNEMRKQLIDLNPSMFKSPVPHTTRQKKTYEENGREYFFVSKEAFE 535

  Fly   448 ADIEAGKFVEHGEYKGHLYGTSAESVKSIVNAGCVCVLSPHYQAIKTLRTAQLKPFLIHVKPPEL 512
            :.:.:..|:|:|||.||:||||.|:||::::||.:|::....|.|..:||.:|||::|.:|||..
Frog   536 SMVYSHGFLEYGEYNGHMYGTSVEAVKAVLDAGMICIIDLEPQCITGVRTHELKPYIIFIKPPSR 600

  Fly   513 DILKATRTEARAKSTFDE--ANARSFTDEEFEDMIKSAERIDFLYGHFFDVELVNGELVNAFEQL 575
            :.::.||..|   |.|.:  .|.: |.:|:|:::.:||::::..:|.|||..:||..|.:|..||
Frog   601 NCMRYTRKNA---SIFTDYYVNMK-FKEEDFQEIEESAKKMEVQFGQFFDQVVVNDNLESATVQL 661

  Fly   576 VQNVQRLENEPVWAPSMWV 594
            :..::..::||.|.|:.|:
Frog   662 MSILRCAQDEPQWIPASWI 680

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
metro	NP_610642.2	L27	17..68	CDD:197794	12/53 (23%)
		L27	75..127	CDD:197794	20/51 (39%)
		PDZ_signaling	139..229	CDD:238492	45/89 (51%)
		SH3_MPP	243..302	CDD:212796	34/58 (59%)
		Guanylate_kin	390..575	CDD:279019	78/186 (42%)
		GuKc	399..580	CDD:214504	75/182 (41%)
mpp4	XP_031749716.1	L27	36..84	CDD:413432	11/48 (23%)
		L27	91..139	CDD:397114	19/48 (40%)
		PDZ	153..232	CDD:214570	44/88 (50%)
		SH3_MPP4	247..307	CDD:212967	35/59 (59%)
		Guanylate_kin	478..666	CDD:395500	80/191 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D245552at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010