Protein Alignment metro and pals1b

DIOPT Version :10

• Sequence 1: NP_610642.2
• Gene: metro / 36176
• FlyBaseID: FBgn0050021
• Length: 595
• Species: Drosophila melanogaster
• Sequence 2: NP_001171218.2
• Gene: pals1b / 100422734
• ZFINID: ZDB-GENE-060531-2
• Length: 639
• Species: Danio rerio
• Alignment Length: 580
• Identity: 208/580 - (35%)
• Similarity: 324/580 - (55%)
• Gaps: 65/580 - (11%)

  Fly    31 NDQEIDFLKALLESKELNALVNVHTKVAKVGRDDRLAP---VLSTSAQVL---YEVLEQLSQHCH 89
            :.|:::.|..||..........:...||: |. .||.|   .|:..||.|   .|.:.|.|:|
Zfish   106 SQQDVELLLDLLLQTNFQQAFIMQRSVAQ-GM-SRLCPPPYPLTAHAQQLRGQVESVLQSSKH-- 166

  Fly    90 LNDDCKEAFHLLQDSHLQHLLFAHDAIAQKDFYPHLPEAPVEMDEDEETIKIVQLVKSNE-PLTG 153
              .:..|...||...|||.|:.|||.||:::......||   :|:||:|.|:|.|.|..: ||
Zfish   167 --TEATELTGLLTSPHLQALMEAHDCIAEQELDVDTIEA---VDQDEKTTKLVSLEKIRDIPL-- 224

  Fly   154 AQSTEPIVGATIKTDEESGKIIIARIMHGGAADRSGLIHVGDEVIEVNNINVEGKTPGDVLTILQ 218
                    |.|::.:::.  ::|:|::.||.|::|.|:..|||::|:|||.|.|||..||..:|.
Zfish   225 --------GVTVRNEQDC--VVISRVVSGGTAEKSNLLSEGDEILEINNIPVRGKTVNDVHDLLS 279

  Fly   219 NSEGTITFKLVP-ADNK-GAQRESKVRVRAHFDYNPDVDPYIPCKEAGLAFQRGDVLHIVAQDDA 281
            :..|::||.|:| :.|| ...|.:.:.|:|:|.|:|..|||:||||.||:|||||:||:.:|||.
Zfish   280 SMYGSLTFLLIPNSHNKLPLDRPTVMHVKANFSYDPSEDPYVPCKELGLSFQRGDILHVTSQDDP 344

  Fly   282 YWWQARKE--HERSARAGLIPSRALQERRILHDRTQKNGTDLDSK-PGS--CASLCTTPPGSPRL 341
            .||||.:|  .::...|||||.:..|:.|   :..:|..||.:.: .|.  ||
Zfish   345 NWWQAYREGHDDQKPLAGLIPGKNFQQHR---EAMKKTITDKNEEYKGKLWCA------------ 394

  Fly   342 PASSSTSSCRQPK-TKKIMYDLTENDDFDREQIATYEEVAKLYPRPGVFRPIVLIGAPGVGRNEL 405
                    .|..| .||::|:..:|.:...|.|.|||||:.....|...||:.|||....|::||
Zfish   395 --------IRSKKHRKKLLYNPNKNIEHYSEDILTYEEVSLYRQPPDRKRPVALIGPANSGQDEL 451

  Fly   406 RRRLIARDPEKFRSPVPYTTRPMRTGEVAGREYIFVAREKMDADIEAGKFVEHGEYKGHLYGTSA 470
            |:||::.:||:|.:.||:|||..|..||.||||.||:|:..::::.||||:|.|||..:||||:|
Zfish   452 RQRLLSSEPERFAAAVPHTTRSPRVHEVNGREYNFVSRQSFESELSAGKFIESGEYGNNLYGTNA 516

  Fly   471 ESVKSIVNAGCVCVLSPHYQAIKTLRTAQLKPFLIHVK--PPELDILKATRTEARAKSTFDEANA 533
            :||:.:||:|.:|:|....::::.|.::.|||::|.::  ||.|    :........||......
Zfish   517 DSVRQVVNSGKICLLCLQPRSLQVLCSSDLKPYIIFIRPSPPPL----SPPPPQERFSTMLARGV 577

  Fly   534 RSFTDEEFEDMIKSAERIDFLYGHFFDVELVNGELVNAFEQLVQNVQRLENEPVWAPSMW 593
            :....|:..:|::.|..::..|||.||..:.|.|...:..:|:..:|:|:|||.|.||.|
Zfish   578 KKRMPEDVREMMEKAREMEDSYGHLFDTFITNNEPEKSVCELLSIIQKLDNEPQWIPSAW 637

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
metro	NP_610642.2	L27	17..68	CDD:197794	9/36 (25%)
		L27	75..127	CDD:197794	18/54 (33%)
		PDZ_MPP3-MPP4-MPP7-like	140..230	CDD:467260	33/90 (37%)
		SH3_MPP	243..302	CDD:212796	34/60 (57%)
		Guanylate_kin	390..575	CDD:395500	69/186 (37%)
pals1b	NP_001171218.2	L27_N	86..133	CDD:462666	4/26 (15%)
		L27	156..197	CDD:197794	16/44 (36%)
		PDZ_MPP5-like	212..291	CDD:467259	33/90 (37%)
		SH3_MPP5	306..367	CDD:212969	34/60 (57%)
		Guanylate_kin	434..626	CDD:395500	71/195 (36%)