DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment metro and pals1

DIOPT Version :9

Sequence 1:	NP_610642.2	Gene:	metro / 36176	FlyBaseID:	FBgn0050021	Length:	595	Species:	Drosophila melanogaster
Sequence 2:	XP_002937246.1	Gene:	pals1 / 100145156	XenbaseID:	XB-GENE-978290	Length:	675	Species:	Xenopus tropicalis

Alignment Length:	603	Identity:	213/603 - (35%)
Similarity:	349/603 - (57%)	Gaps:	74/603 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LSKLISTLKESENL----SNDQEIDFLKALLESKELNALVNVHTKVA----KVGRDDRLAPVLST 72
            :..|||:||:.::.    .:.::|..|..|.::.:......:|..||    |......|.|
Frog   124 IEDLISSLKDIQHTLVDSQSQEDISVLLQLAQNVDFQNAFKIHNAVAVHMNKTSPPYPLVP---- 184

  Fly    73 SAQVLYEVLEQLSQHCHLNDDCKEAFHLLQDSHLQHLLFAHDAIAQKDFYPHLPEAPVEMD---- 133
            :||.|.:.::|:.:..|..:. :|...||...|:|.||.|||.:|:::..|.    |...|
Frog   185 NAQDLTQEVQQVLKSSHQKEG-QELSALLNTPHIQALLLAHDKVAEQEMMPE----PASDDYFYE 244

  Fly   134 ----EDEETIKIVQLVKSNE-PLTGAQSTEPIVGATIKTDEESGKIIIARIMHGGAADRSGLIHV 193
                ..:||:|||::.|:.: ||          |||::.|.:|  :||:||:.||||::|||:|.
Frog   245 NIGLYGDETVKIVRIEKARDIPL----------GATVRNDGDS--VIISRIVKGGAAEKSGLLHE 297

  Fly   194 GDEVIEVNNINVEGKTPGDVLTILQNSEGTITFKLVPADNK--GAQRESKVRVRAHFDYNPDVDP 256
            |||::::|.:.:.||...:|..:|.:..|.::|.|:|....  ...:|:.|.|:|||||:|..||
Frog   298 GDEILQINGMEIRGKDVNEVFELLADMHGNLSFLLIPGQQSKPPPSKETVVHVKAHFDYDPSDDP 362

  Fly   257 YIPCKEAGLAFQRGDVLHIVAQDDAYWWQARK--EHERSARAGLIPSRALQERRILHDRTQKNGT 319
            |:||:|.||:||:||:||:::|:|..||||.:  :.:....|||:|.::.|::|    ...|...
Frog   363 YVPCRELGLSFQKGDILHVISQEDPNWWQAYRDGDEDNQPLAGLVPGKSFQQQR----EAMKQTI 423

  Fly   320 DLDSKPGSCASL-CTTPPGSPRLPASSSTSSCRQPKTKKIMYDLTENDDFDREQIATYEEVAKLY 383
            :.|.:|.....| |               :...:.|.||::|:..:|||:|.|:|.||||:: ||
Frog   424 EEDKEPEKSGKLWC---------------AKKNKKKRKKVLYNANKNDDYDNEEILTYEEMS-LY 472

  Fly   384 PRP-GVFRPIVLIGAPGVGRNELRRRLIARDPEKFRSPVPYTTRPMRTGEVAGREYIFVAREKMD 447
            .:| ...|||:|||....|:||||:||:..:||:|.:.||:|||..|..|:|||:|.||:|:..|
Frog   473 HQPANRKRPIILIGPQSCGQNELRQRLMTNEPERFAAAVPHTTRSRRENELAGRDYHFVSRQTFD 537

  Fly   448 ADIEAGKFVEHGEYKGHLYGTSAESVKSIVNAGCVCVLSPHYQAIKTLRTAQLKPFLIHVKPPEL 512
            |||.||||:|.||::.:|||||.:||:.::|:..:|:|..|.|::|.||.:.|||::|.:.||..
Frog   538 ADISAGKFIEFGEFEKNLYGTSIDSVRQVINSSKICLLCLHTQSLKMLRNSDLKPYIIFIAPPSQ 602

  Fly   513 DILKATRTEARAKSTFDEANARSFTDEEFEDMIKSAERIDFLYGHFFDVELVNGELVNAFEQLVQ 577
            :.|:|...:          ..|:...||..::|:.|..::...|||||..:||.:|..|:::|::
Frog   603 ERLRALLAK----------EGRNPKPEELREIIEKAREMEQNNGHFFDTAIVNTDLDKAYQELLR 657

  Fly   578 NVQRLENEPVWAPSMWVQ 595
            .:.:|:.||.|.||.|::
Frog   658 LINKLDTEPQWVPSSWLR 675

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
metro	NP_610642.2	L27	17..68	CDD:197794	13/58 (22%)
		L27	75..127	CDD:197794	16/51 (31%)
		PDZ_signaling	139..229	CDD:238492	33/90 (37%)
		SH3_MPP	243..302	CDD:212796	31/60 (52%)
		Guanylate_kin	390..575	CDD:279019	78/184 (42%)
		GuKc	399..580	CDD:214504	73/180 (41%)
pals1	XP_002937246.1	L27_N	123..170	CDD:370269	9/45 (20%)
		L27	186..236	CDD:367207	17/54 (31%)
		PDZ_signaling	254..333	CDD:238492	33/90 (37%)
		SH3_MPP5	349..411	CDD:212969	31/61 (51%)
		GuKc	491..661	CDD:214504	73/179 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D245552at33208
OrthoFinder	1	1.000	-	-		FOG0000824
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010