DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7737 and Smox

DIOPT Version :9

Sequence 1:	NP_001286308.1	Gene:	CG7737 / 36174	FlyBaseID:	FBgn0033584	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	XP_006235125.1	Gene:	Smox / 308652	RGDID:	1306049	Length:	585	Species:	Rattus norvegicus

Alignment Length:	591	Identity:	166/591 - (28%)
Similarity:	250/591 - (42%)	Gaps:	120/591 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 PGMSGAQRNQDRKIVVIGAGASGVACATKLLELGFQNVLVVEAEDRLGGRIHTIPFADNVIDLGA 97
            |...|.:|....::||||||.:|:|.|..|||.||.:|.|:||...:|||:.::.......:|||
  Rat    14 PLSRGLRRRGQPRVVVIGAGLAGLAAARALLEQGFTDVTVLEASSHIGGRVQSVKLGHATFELGA 78

  Fly    98 QWCHGERDNIVYELTRKQDEELLESTGPVYENYECVRSNGDV------------------VPEEV 144
            .|.||...|.:|:|.        |:.|.:.|..:..||.|.:                  :|::|
  Rat    79 TWIHGSHGNPIYQLA--------EANGLLEETTDGERSVGRISLYSKNGVACYLTNRGRRIPKDV 135

  Fly   145 SSRLKAIVGDSLVTRQLELRH-------CSGSLGSYLTNKFYDTLR-RPENSDIDAEVASEFFVN 201
            ......:..:.....|...|:       ...|:|.:...|..:.:| .|::::....:.......
  Rat   136 VEEFSDLYNEVYNLTQEFFRNGKPVNAESQNSVGVFTREKVRNRIRDDPDDTEATKRLKLAMIQQ 200

  Fly   202 YQKFENSVEASDTLEQVSGRGYLDYWECEG--DILLNWKDKGYVELLRLLMRSRELNVEHGVLEQ 264
            |.|.|:...:|.::::||...:.::.|..|  .|:    ..|::.::.||.:        |:...
  Rat   201 YLKVESCESSSHSIDEVSLSAFGEWTEIPGAHHII----PSGFMRVVELLAK--------GIPPH 253

  Fly   265 RLLLGTRVVKINW--------------------------------NRNDGR--------VELQMS 289
            .:.||..|..|:|                                |...||        |.::..
  Rat   254 VIQLGKPVRCIHWDQASARPRGPEIEPRGEGDHNHDAGEGGQSGENPQQGRWDEDEQWPVVVECE 318

  Fly   290 NGETCIADHVVVTVSLGVLKDQHLRLFEPQLPVEKQRAIDGLAFGTVNKIFVEFPEAFWPEDWTG 354
            :.|...||||:|||||||||.|:...|.|.||.||..||..|..||.:|||:||.|.||..:...
  Rat   319 DCEVIPADHVIVTVSLGVLKRQYTSFFRPCLPTEKVAAIHRLGIGTTDKIFLEFEEPFWGPECNS 383

  Fly   355 FTMLWRDE-DLDDIRGTSRAWLEDVFGFYRVSYQP----RILAGWITNESGRHMETLPVDEVQAG 414
            ...:|.|| :...:......|...:.|| .|.|.|    .:|:|||..|....||....:.|...
  Rat   384 LQFVWEDEAESCTLTYPPELWYRKICGF-DVLYPPERYGHVLSGWICGEEALVMERCDDEAVAEI 447

  Fly   415 VMYLFRRFL-RWKIPDPANFRTSAWYTNDNFRGSYSYRSMDTEQLGTGARELSHPLTVVATTPEK 478
            ...:.|:|. ...||.|.....|||.:|..|||||||..:.:.  |....:|:.||...    |.
  Rat   448 CTEMLRQFTGNPNIPKPRRILRSAWGSNPYFRGSYSYTQVGSS--GADVEKLAKPLPYT----ES 506

  Fly   479 DKDSEDEAWQQ-------SRCD-----------RPI-VQFAGEASSEHYYSTVHGAVEAGWREAR 524
            .|.:...:.:|       |:|.           :|: |.|:|||:...||||.|||:.:|.|||.
  Rat   507 SKTAHGSSTKQQPGHLLSSKCPEQSLDPSRGSIKPMQVLFSGEATHRKYYSTTHGALLSGQREAA 571

  Fly   525 RLAQFY 530
            ||.:.|
  Rat   572 RLIEMY 577

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7737	NP_001286308.1	NAD_binding_8	48..106	CDD:290186	26/57 (46%)
CG7737	NP_001286308.1	Amino_oxidase	54..526	CDD:279874	154/564 (27%)
Smox	XP_006235125.1	NAD_binding_8	<45..88	CDD:290186	16/42 (38%)
Smox	XP_006235125.1	PLN02568	50..578	CDD:215308	149/555 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343430
Domainoid	1	1.000	138	1.000	Domainoid score	I4710
eggNOG	1	0.900	-	-		E1_KOG0685
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D375579at33208
OrthoFinder	1	1.000	-	-		FOG0000632
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102123
Panther	1	1.100	-	-	O	PTHR10742
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X429
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.750