DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7737 and Lao1

DIOPT Version :9

Sequence 1:	NP_001286308.1	Gene:	CG7737 / 36174	FlyBaseID:	FBgn0033584	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_001100152.1	Gene:	Lao1 / 298483	RGDID:	1310787	Length:	519	Species:	Rattus norvegicus

Alignment Length:	566	Identity:	125/566 - (22%)
Similarity:	217/566 - (38%)	Gaps:	172/566 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 RKIVVIGAGASGVACATKLLELGFQNVLVVEAEDRLGGRIHT----------------IPFADNV 92
            ::|||:|||.:|:. |.|||:.....|.::||.:.:|||:.|                ||.:..:
  Rat    58 KRIVVVGAGMAGLV-AAKLLQDAGHEVTILEASNHIGGRVVTLRNKEEGWHFELGPMRIPESHRI 121

  Fly    93 IDLGAQWC------HGERDNIVYELTRKQDEELLESTGPVYENYECVRSNGDVVPEEVSSRLKAI 151
            |....|..      ..:.||..:.|.|          |..|...| |::|    ||        |
  Rat   122 IHTYIQKFGLKLNNFTQHDNNTWYLLR----------GHRYRASE-VKAN----PE--------I 163

  Fly   152 VGDSLVTRQLELRHCSGSLGSYLTNKFYDTLRRPENSDIDAEVASEFFVNYQKFENSVEASDTLE 216
            :|..|  |..|....:..|       ||..:.:     :.|...|:....|..:  |.:|....|
  Rat   164 LGYPL--RPSEKNKTAEDL-------FYQAITK-----VKASNCSQLLSLYDSY--STKAYLLKE 212

  Fly   217 QVSGRGYLDYWECEGDILLNWKDKGY----VELLRL-------------------LMRSRELNVE 258
            .:..||.:   |..|| ::| ::.|:    :|.||:                   |..|...:::
  Rat   213 GMLSRGAV---EMIGD-MMN-ENAGFYRSLLESLRIANIFTKNDQFTEITGGFDQLPNSLNDSLK 272

  Fly   259 HGVLEQRLLLGTRVVKINWNRNDGRVE-LQMSNGET-----CIADHVVVTVSLGVLKDQHLRLFE 317
            .|.:.    ||::|.::  ..|:.:|| |..::|.|     ..||:|:::.|   .|...|..|:
  Rat   273 PGTIH----LGSKVERV--VGNESKVEVLYRTDGPTSALYNLTADYVIISAS---AKATRLIAFQ 328

  Fly   318 PQLPVEKQRAIDGLAFGTVNKIFVEFPEAFWPEDWT--GFTMLWRDEDLDDIRGTSRAWLEDVFG 380
            |.|..||.||:..:.:.:..|:.....|.||.:|..  |:::..|         .||      |.
  Rat   329 PPLSPEKIRALRSVHYNSATKVIFVCNERFWEKDGIHGGYSITDR---------PSR------FI 378

  Fly   381 FY----RVSYQPRILAGWITNESGRHMETLPVDEV-------QAGVMYLFRRFLRWKIPDPANFR 434
            :|    |.|.:..:||.:..::.......|..::|       .|.|..:.:..|:...|
  Rat   379 YYPSYSRPSSKGILLASFTMDDDSFFFTALKPNQVVDIILDDLAAVHLIPKEELKRMCP------ 437

  Fly   435 TSAWYTNDNFRGSYSYRSMDTEQLGTGARELSHPLTVVATTPEKDKDSEDEAWQ-QSRCDRPIVQ 498
                      :....:.|:|...:|:.|.          .||.:..|...:..| :.|     :.
  Rat   438 ----------KSEVKHWSLDPFTIGSYAE----------FTPYQFLDDLKQLSQTEGR-----IY 477

  Fly   499 FAGEASS-EHYYSTVHGAVEAGWREARRLAQFYGISVSRSGTKSQL 543
            ||||.:| .|.:  :..|:::|.|.|:.:..    :|.:..|:.|:
  Rat   478 FAGEHTSLPHAW--IETAIKSGIRAAKNIQD----TVDKEATQGQV 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7737	NP_001286308.1	NAD_binding_8	48..106	CDD:290186	20/79 (25%)
CG7737	NP_001286308.1	Amino_oxidase	54..526	CDD:279874	116/537 (22%)
Lao1	NP_001100152.1	NAD_binding_8	62..>125	CDD:290186	19/63 (30%)
Lao1	NP_001100152.1	Amino_oxidase	67..504	CDD:279874	116/538 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343401
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840