DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7737 and Maoa

DIOPT Version :9

Sequence 1:	NP_001286308.1	Gene:	CG7737 / 36174	FlyBaseID:	FBgn0033584	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_387502.1	Gene:	Maoa / 29253	RGDID:	61898	Length:	526	Species:	Rattus norvegicus

Alignment Length:	558	Identity:	124/558 - (22%)
Similarity:	214/558 - (38%)	Gaps:	147/558 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 MHNIQLPGMSGAQRNQDRKIVVIGAGASGVACATKLLELGFQNVLVVEAEDRLGGRIHTIPFADN 91
            |.:::.|.::|...:    :||||.|.||:| |.|||.....||||:||.||:|||.:|:. .::
  Rat     1 MTDLEKPNLAGHMFD----VVVIGGGISGLA-AAKLLSEYKINVLVLEARDRVGGRTYTVR-NEH 59

  Fly    92 V--IDLGAQWCHGERDNIVYELTRK---------QDEELLE----STGP------------VYEN 129
            |  :|:|..:. |...|.:..|:::         .:|.|::    .|.|            .|.:
  Rat    60 VKWVDVGGAYV-GPTQNRILRLSKELGIETYKVNVNERLVQYVKGKTYPFRGAFPPVWNPLAYLD 123

  Fly   130 YECVRSNGDVVPEEVSSRLKAIVGDSLVTRQLELRHCSGSLGSYLTNKFYDTLRRPENSD--IDA 192
            |..:....|.:.:|:.           |....:.||.          :.:|.:...:..|  ...
  Rat   124 YNNLWRTMDEMGKEIP-----------VDAPWQARHA----------QEWDKMTMKDLIDKICWT 167

  Fly   193 EVASEF---FVNYQKFENSVEASDTLEQVSGRGYLDY-WECEG-----DILLNWKDKGYV----E 244
            :.|.||   |||       :..:....:||...:|.| .:|.|     .:....:::.:|    :
  Rat   168 KTAREFAYLFVN-------INVTSEPHEVSALWFLWYVRQCGGTARIFSVTNGGQERKFVGGSGQ 225

  Fly   245 LLRLLMRSRELNVEHGVLEQRLLLGTRVVKINWNRNDGRVELQMSNGETCIADHVVVTVSLGVLK 309
            :...:|         |:|..::.|.:.|..|  ::.|..:.::..|.|.....:|:..:...:..
  Rat   226 VSEQIM---------GLLGDKVKLSSPVTYI--DQTDDNIIVETLNHEHYECKYVISAIPPILTA 279

  Fly   310 DQHLRLFEPQLPVEKQRAIDGLAFGTVNKIFVEFPEAFW-PEDWTGFTMLWRDED------LDDI 367
            ..|   |:|:||.|:.:.|..|..|.|.|..|.:.|||| .:|:.| .|:..||:      |||.
  Rat   280 KIH---FKPELPPERNQLIQRLPMGAVIKCMVYYKEAFWKKKDYCG-CMIIEDEEAPIAITLDDT 340

  Fly   368 RGTSRAWLEDVFGFYRVSYQPRILAGWITNESGRHMETLPVDEVQAGVMYLFRRFL-RWKIPDPA 431
            :.....              |.|: |:|.......:..|..|..:..:..|:.:.| ..:...|.
  Rat   341 KPDGSL--------------PAIM-GFILARKADRLAKLHKDIRKRKICELYAKVLGSQEALYPV 390

  Fly   432 NFRTSAWYTNDNFRGSYSYRSMDTEQLGTGARELSHPLTVVATTPEKDKDSEDEAWQQSRCDR-P 495
            ::....|.               .||...|......|..::.              |..|..| |
  Rat   391 HYEEKNWC---------------EEQYSGGCYTAYFPPGIMT--------------QYGRVIRQP 426

  Fly   496 I--VQFAGEASSEHYYSTVHGAVEAGWREARRLAQFYG 531
            :  :.|||..::..:...:.||||||.|.||.:....|
  Rat   427 VGRIYFAGTETATQWSGYMEGAVEAGERAAREVLNALG 464

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7737	NP_001286308.1	NAD_binding_8	48..106	CDD:290186	27/59 (46%)
CG7737	NP_001286308.1	Amino_oxidase	54..526	CDD:279874	115/524 (22%)
Maoa	NP_387502.1	YobN	15..463	CDD:224152	120/541 (22%)
		NAD_binding_8	18..84	CDD:290186	29/68 (43%)
		Interaction with membrane phospholipid headgroups. /evidence=ECO:0000250	520..522
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343408
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840