DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7737 and lsd1

DIOPT Version :9

Sequence 1:	NP_001286308.1	Gene:	CG7737 / 36174	FlyBaseID:	FBgn0033584	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_595398.1	Gene:	lsd1 / 2539805	PomBaseID:	SPBC146.09c	Length:	1000	Species:	Schizosaccharomyces pombe

Alignment Length:	569	Identity:	119/569 - (20%)
Similarity:	206/569 - (36%)	Gaps:	147/569 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 RKIVVIGAGASGVACATKLLELGFQ-------------NVLVVEAEDRLGGRI--HTIPFADNVI 93
            :.:.:||||.:|::||.:|..|..|             .:::.||.:||||.|  |.:|.:||.:
pombe   258 KTVAIIGAGMAGISCARQLTNLFAQYEQDFLSRGEKPPRIVIYEASERLGGHIYTHMVPLSDNEV 322

  Fly    94 DLGAQWCHGERDNIVYELTRKQD-------EELLE----STGPVYENYECVRSNGDVVPEEVSSR 147
                    .|:.::...:....:       :.|:.    .:.|:|     :.|:..:..:.|.:|
pombe   323 --------SEKSSLATTVNATNECMVNLLTDSLIGMPTLDSDPLY-----IISSQQLSLDAVHTR 374

  Fly   148 LKAIVGDSLVTRQLELRHCSGSLGSYLTNKFY---DTLRRPENSDIDAEVASEFFVNYQKFEN-- 207
            .:..:...:...:::..|.......:....||   ...::|.:|.| .....||.   ||.:.
pombe   375 NREFILHDIENGRIDTEHVQRIFRLFDALLFYFNASASKQPLHSLI-TPPEQEFI---QKLDQIG 435

  Fly   208 ---SVEA-----SDTLEQVSGRG--------------------YLDYWECEGDILLNWKDKGYVE 244
               |:||     .|||.:..|..                    :.:|......:.|.....|.:.
pombe   436 WYISIEAFPLQIKDTLSEFLGNSANTLTSLLHLTVLDLKIFEWFKEYLSQSLSVSLENVYPGSIP 500

  Fly   245 LLRLLMRSR--ELNVEHGVLEQRLLLGT-------------RVVKINWNRNDGRVELQMSNGETC 294
            .|.||:...  ..:.:||:.:....|.:             ..||:    .|..|.|...|..|.
pombe   501 NLNLLLGENVASYSFKHGMADMLNSLASTPSPLPILFDQCVHTVKL----EDNTVNLSFVNETTV 561

  Fly   295 IADHVVVTVSLGVLKDQHLRLFEPQLPVEKQRAIDGLAFGTVNKIFVEFPEAFWPEDWTGFTMLW 359
            ..|.||:.:.:..| :.||..|||.|..:|.:|||...|..|.|:.:.|...||..:.:.|..|.
pombe   562 SVDKVVICIPMDKL-NTHLITFEPPLEEKKLKAIDRCHFTNVKKVILIFKTQFWEPNISIFGSLP 625

  Fly   360 RDEDLDDIRGTSRAWLEDVFGFYRVSYQPRILAGWITNESGRHMETLPVDEVQAGVMYLFRRFLR 424
            :|...:.|       ..|...|    |:...|:.::..|.   ::.:..|::..|::...::..:
pombe   626 QDSGRNFI-------FNDCTRF----YEHPTLSVFVKVEG---IDFMKDDDIVNGIVSQLKKVYK 676

  Fly   425 WKIP--DPANFRTSAW----YTNDNFRGSYSYRSMDTEQLGTGARELSHPLTVVATTPEKDKDSE 483
            .|..  :|.....|.|    |||   ..||...::..|                          |
pombe   677 PKSEAINPIRTIISNWENNSYTN---HSSYQISNLFLE--------------------------E 712

  Fly   484 DEAWQQSRCDRPIVQFAGEASSEHYYSTVHGAVEAGWREARR-LAQFYG 531
            |.|......|..:. ||.||.|:....::.||.::|...||. ||...|
pombe   713 DYAILSEPIDNTVF-FASEAISQKNSGSIRGAFDSGILAARDVLASLIG 760

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7737	NP_001286308.1	NAD_binding_8	48..106	CDD:290186	22/72 (31%)
CG7737	NP_001286308.1	Amino_oxidase	54..526	CDD:279874	112/552 (20%)
lsd1	NP_595398.1	SWIRM	157..240	CDD:282311
		NAD_binding_8	262..>316	CDD:290186	18/53 (34%)
		Amino_oxidase	267..755	CDD:279874	112/553 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	2	1.870