Protein Alignment CG7737 and KDM1A

DIOPT Version :9

• Sequence 1: NP_001286308.1
• Gene: CG7737 / 36174
• FlyBaseID: FBgn0033584
• Length: 543
• Species: Drosophila melanogaster
• Sequence 2: XP_006710537.1
• Gene: KDM1A / 23028
• HGNCID: 29079
• Length: 878
• Species: Homo sapiens
• Alignment Length: 603
• Identity: 141/603 - (23%)
• Similarity: 236/603 - (39%)
• Gaps: 161/603 - (26%)

  Fly    45 KIVVIGAGASGVACATKLLELGFQNVLVVEAEDRLGGRIHTIPFADNVIDLGAQWCHGERDNIVY 109
            |:::||:|.||:|.|.:|...| .:|.::||.||:|||:.|....:.|.||||....|...|.:.
Human   300 KVIIIGSGVSGLAAARQLQSFG-MDVTLLEARDRVGGRVATFRKGNYVADLGAMVVTGLGGNPMA 363

  Fly   110 ELTRKQDEEL--LESTGPVYENYECVRSNGDVVPEEVSSRL-----KAIVGDSLVTRQLE---LR 164
            .::::.:.||  ::...|:||      :||..||:|....:     :.:...|.::.||:   |.
Human   364 VVSKQVNMELAKIKQKCPLYE------ANGQAVPKEKDEMVEQEFNRLLEATSYLSHQLDFNVLN 422

  Fly   165 HCSGSLG--------------------------------SYLTNKFYDTLRR--------PENSD 189
            :...|||                                ..|.||..:...:        .|.|:
Human   423 NKPVSLGQALEVVIQLQEKHVKDEQIEHWKKIVKTQEELKELLNKMVNLKEKIKELHQQYKEASE 487

  Fly   190 I--DAEVASEFFV--NYQKFENSVEASDTLEQVSGRGYLDYWECE----------GDILLNWKDK 240
            :  ..::.:||.|  .::......:..|.|.:..|:......|.|          .|:.|:.:|
Human   488 VKPPRDITAEFLVKSKHRDLTALCKEYDELAETQGKLEEKLQELEANPPSPLFFCSDVYLSSRD- 551

  Fly   241 GYVELLRLLMRSRELNVEHGVLEQRLLLGTRVVKINWNRNDG----RVELQMSNGETCI------ 295
                  |.::.....|:|   ......|.|..:| :|:::|.    ...|.:.||.:|:
Human   552 ------RQILDWHFANLE---FANATPLSTLSLK-HWDQDDDFEFTGSHLTVRNGYSCVPVALAE 606

  Fly   296 -------------------------------------ADHVVVTVSLGVLKDQHLRL-FEPQLPV 322
                                                 .|.|:.|:.|||||.|...: |.|.||.
Human   607 GLDIKLNTAVRQVRYTASGCEVIAVNTRSTSQTFIYKCDAVLCTLPLGVLKQQPPAVQFVPPLPE 671

  Fly   323 EKQRAIDGLAFGTVNKIFVEFPEAFWPEDWTGFTMLWRDEDLDDIRGTSRAWLEDVFGFYRVSYQ 387
            .|..|:..:.||.:||:.:.|...||......|..:          |::.|...::|.|:.: |:
Human   672 WKTSAVQRMGFGNLNKVVLCFDRVFWDPSVNLFGHV----------GSTTASRGELFLFWNL-YK 725

  Fly   388 PRILAGWITNESGRHMETLPVDEVQAGVMYLFRR-FLRWKIPDPANFRTSAWYTNDNFRGSYSYR 451
            ..||...:..|:...||.:..|.:....:.:.:. |....:|.|.....|.|..:...||||||.
Human   726 APILLALVAGEAAGIMENISDDVIVGRCLAILKGIFGSSAVPQPKETVVSRWRADPWARGSYSYV 790

  Fly   452 SMDTEQLGTGARELSHPLTVVATTPEKDKDSEDEAWQQSRCDRPIVQ--FAGEASSEHYYSTVHG 514
            :..:.  |.....::.|:|...:.|              ...:||.:  ||||.:..:|.:||||
Human   791 AAGSS--GNDYDLMAQPITPGPSIP--------------GAPQPIPRLFFAGEHTIRNYPATVHG 839

  Fly   515 AVEAGWREARRLA-QFYG 531
            |:.:|.|||.|:| ||.|
Human   840 ALLSGLREAGRIADQFLG 857

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7737	NP_001286308.1	NAD_binding_8	48..106	CDD:290186	24/57 (42%)
		Amino_oxidase	54..526	CDD:279874	132/586 (23%)
KDM1A	XP_006710537.1	SWIRM	197..284	CDD:282311
		NAD_binding_8	303..361	CDD:290186	24/58 (41%)
		Amino_oxidase	308..851	CDD:279874	132/587 (22%)
		SurA_N_3	<395..491	CDD:304439	12/95 (13%)
		NAT_SF	<441..>549	CDD:302625	15/107 (14%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0685
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810